Publications by authors named "Xuewen Tan"

Escherichia coli (E. coli) is a type of pathogenic bacteria that often causes diarrhea in poultry. While antibiotics can control E.

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In this paper, a Caputo fractional tumor immune model of combination therapy is established. First, the stability and biological significance of each equilibrium point are analyzed, and it is demonstrated that chaos may arise under specific conditions. Combined with the mathematical definition of Caputo fractional differentiation (CFD), it is found that there is a high correlation between the chaotic phenomenon of the patient's condition and the sensitivity of the patient to the change in the state of the day.

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Article Synopsis
  • T helper 9 (Th9) cells, which express the transcription factor PU.1 and produce interleukin-9 (IL-9), may play a significant role in the development of rheumatoid arthritis (RA), but more research is needed to understand this relationship.
  • In this study, researchers measured PU.1 and IL-9 levels in RA patients and used various knockout mice models to assess the effects of targeting these proteins on inflammation related to RA.
  • The findings revealed a positive feedback loop between PU.1 and IL-9 that exacerbates RA, suggesting that disrupting this signaling pathway could be a promising strategy for RA treatment.
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Cimicifugae rhizoma is a traditional Chinese herbal medicine in China, and modern pharmacological research showed that it has obvious antiviral activity. Many polysaccharides have been proved to have immune enhancement and antiviral activity, but there are few studies on the biological activity of Cimicifuga rhizoma polysaccharide (CRP). The aim was to explore the character of CRP and its effects on improving immune activity and inhibiting transmissible gastroenteritis virus (TGEV).

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This study aimed to assess the impact of light perception presence or absence on visual function recovery in patients with traumatic optic neuropathy (TON). A retrospective analysis was conducted on the clinical data of 206 TON patients. Based on the presence or absence of light perception after injury, patients were categorized into a light perception group and a non-light perception group.

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Transmissible gastroenteritis virus (TGEV) is an important pathogen capable of altering the expression profile of cellular miRNA. In this study, the potential of Polygonum cillinerve polysaccharide (PCP) to treat TGEV-infected piglets was evaluated through in vivo experiments. High-throughput sequencing technology was employed to identify 9 up-regulated and 17 down-regulated miRNAs during PCP-mediated inhibition of TGEV infection in PK15 cells.

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Excessive phosphorus (P) and ammonia nitrogen (NH-N) in water bodies can lead to eutrophication of the aquatic environment. Therefore, it is important to develop a technology that can efficiently remove P and NH-N from water. Here, the adsorption performance of cerium-loaded intercalated bentonite (Ce-bentonite) was optimized based on single-factor experiments using central composite design-response surface methodology (CCD-RSM) and genetic algorithm-back propagation neural network (GA-BPNN) models.

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Rheumatoid arthritis (RA) is a multisystemic and inflammatory autoimmune disease characterized by joint destruction. The C-C motif chemokine receptor 2 (CCR2) is mainly expressed in monocytes and T cells, initiating their migration to sites of inflammation, ultimately leading to cartilage damage and bone destruction. CCR2 has long been considered a prospective target for treating autoimmune diseases.

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Objectives: To uncover the function and underlying mechanism of an essential transcriptional factor, PU.1, in the development of rheumatoid arthritis (RA).

Methods: The expression and localisation of PU.

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The tumor-suppressor role of long noncoding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) has been proven in various types of cancer. However, the specific function of GAS5 in tumor-associated macrophages (TAMs) of endometrial cancer (EC) is elusive. Quantitative PCR results showed that GAS5 expression decreased in EC tissues and primary TAMs from EC tumors.

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Rheumatoid arthritis (RA) is an inflammation-involved disorder and features the disruption of CD4 T lymphocytes. Herein, we describe that microRNA-10b-5p (miR-10b) promotes RA progression by disrupting the balance between subsets of CD4 T cells. MiR-10b-deficient mice protected against collagen antibody-induced arthritis (CAIA) model.

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Macrophage-mediated tumor cell phagocytosis and subsequent neoantigen presentation are critical for generating anti-tumor immunity. This study aimed to uncover the potential clinical value and molecular mechanisms of miRNA-22 (miR-22) in tumor cell phagocytosis via macrophages and more efficient T cell priming. We found that miR-22 expression was markedly downregulated in primary macrophages from glioma tissue samples compared to adjacent tissues.

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Chimeric antigen receptor (CAR)-T cell therapy has been shown to be an effective treatment for hematological tumors, but the treatment of solid tumors still lacks effectiveness. In the tumor microenvironment, macrophages are the innate immune cells with the highest infiltration rate. Tumor-associated macrophages (TAMs) stimulate angiogenesis, increase tumor invasion, and mediate immunosuppression.

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Article Synopsis
  • Glioma is a serious brain tumor that usually has a bad outlook for patients.
  • The long non-coding RNA called GAS5 has been found to be dysfunctional in many cancers, including glioma, and it appears to be important for tumor behavior.
  • Research suggests GAS5 could serve as a marker for glioma diagnosis and prognosis, and could also be a potential treatment target, indicating a need for more studies.
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Glioma is the most commonly observed primary intracranial tumour and is associated with massive angiogenesis. Glioma neovascularization provides nutrients for the growth and metabolism of tumour tissues, promotes tumour cell division and proliferation, and provides conditions ideal for the infiltration and migration of tumour cells to distant places. Growing evidence suggests that there is a correlation between the activation of nuclear factor (NF)-κB and the angiogenesis of glioma.

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Osteoarthritis (OA), the most ubiquitous degenerative disease affecting the entire joint, is characterized by cartilage degradation and synovial inflammation. Although the pathogenesis of OA remains poorly understood, synovial inflammation is known to play an important role in OA development. However, studies on OA pathophysiology have focused more on cartilage degeneration and osteophytes, rather than on the inflamed and thickened synovium.

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This paper proposes a discrete switching predator-prey model with a mate-finding Allee effect, where also switches are guided by Allee effect. One of the strategies analysed is to use a chemical in order to prevent the pest outbreak when the pest population is free of Allee effect. In this paper, we first study analytically the dynamic behaviors of the two subsystems and the equilibria and their stability of the switched system.

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