Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Surface defect engineering is an effective strategy to regulate the physical and chemical properties of semiconductors for a wide range of applications. Herein, a surface-highly-reduced anatase TiO (R-TiO) with double defects (surface oxygen vacancy defect and Ti energy level defect) was developed as a plasmon-free surface-enhanced Raman scattering (SERS) substrate for ultrasensitive detection of food additives. Abundant surface oxygen vacancies enable R-TiO to exist stably in liquid phase, which realizes a smart SERS detection for dye target molecules due to evading fluorescent interference from analytes, while SERS enhancement of analytes cannot be observed on the solid phase substrate at all.
View Article and Find Full Text PDFCardiac biomarkers are being increasingly applied in pediatric populations, including those with cardiogenic and non-cardiogenic myocardial injury disease. The upper reference limits of biomarkers are an important reference for disease diagnosis and health evaluation. However, the upper reference limits of pediatric cardiac biomarkers remains unknown.
View Article and Find Full Text PDFThis study aims to elucidate the role of minichromosome maintenance protein 4 (MCM4) in malignant melanoma (MM) and explore the underlying mechanism. Initially, data from The Cancer Genome Atlas (TCGA) database and the Molecular Signature Database (MSigDB) were used to investigate the biological impact of MCM4 on MM. Further, a prognostic model using Cox regression analysis was developed to predict the overall survival (OS) rate in the MM patients.
View Article and Find Full Text PDFWith the soaring use of rare earth elements (REEs) worldwidely in high-technology and clean energy industries, there were growing concerns for adverse health effect from the REEs exposure. However, there is a lack of biomonitoring research concerning both urine and blood in population with definite exposure. We performed a biomonitoring study that involved 103 REEs exposed males and 110 males as non-REEs exposed controls.
View Article and Find Full Text PDFThe emergent reconfigurable metasurfaces (RMs) have attracted a lot of attention due to their potential in broad applications. As a general platform, RMs are able to control the reflection (or refraction) of incident waves with predefined functionalities. Nevertheless, the operation of RMs is highly dependent on the arrival direction of incidence.
View Article and Find Full Text PDFCatalytic ozone oxidation, which is characterized by strong oxidizing properties and environmental friendliness, has been widely used in organic wastewater treatments. However, problems such as a low organic pollutant removal efficiency and unstable operation during the catalytic ozone treatment process for wastewater remain. To address these disadvantages, in this study, the treatment efficacy of catalytic ozone oxidation on a coal chemical reverse osmosis concentrate was investigated.
View Article and Find Full Text PDFBackground: Excessive daytime sleepiness (EDS) and freezing of gait (FOG) are prevalent non-motor and motor symptoms in patients with Parkinson's disease (PD), significantly impacting their quality of life. However, the correlation between EDS and FOG progression in de novo PD patients remains controversial.
Methods: A total of 328 participants from the Parkinson's Progression Markers Initiative (PPMI) were divided into two groups: 43 with EDS (EDS group) and 285 without EDS (nEDS group).
Sheng Wu Gong Cheng Xue Bao
September 2024
Tumor recurrence and metastasis remain formidable challenges in clinical oncology. Although surgery is an effective treatment for early-stage solid tumors, residual cancer cells can lead to subsequent recurrence or metastasis. Conventional treatments for melanoma, such as anti-tumor medications and gene therapy, have distinct limitations.
View Article and Find Full Text PDFTumor cell-derived extracellular vesicles (TEVs) contain numerous cellular molecules and are considered potential biomarkers for non-invasive liquid biopsy. However, due to the low abundance of TEVs secreted by tumor cells and their phenotypic heterogeneity, there is a lack of sensitive and specific methods to quantify TEVs. Here, we developed a dual-aptamer proximity ligation-coupled hybridization chain reaction (HCR) method for tracing TEVs, exploiting CRISPR to achieve highly sensitive detection.
View Article and Find Full Text PDFBackground: Benzo(a)pyrene (B[a]P) is the most widely concerned polycyclic aromatic hydrocarbons (PAHs), which metabolizes benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) in vivo to produce carcinogenic effect on the body. Currently, there is limited research on the role of the variation of metabolic enzymes in this process.
Methods: We carried out a study including 752 participants, measured the concentrations of 16 kinds PAHs in both particle and gaseous phases, urinary PAHs metabolites, leukocyte BPDE-DNA adduct and serum BPDE- Albumin (BPDE-Alb) adduct, and calculated daily intake dose (DID) to assess the cumulative exposure of PAHs.
Removing free hemoglobin generated during extracorporeal circulation remains a challenge. Currently, there is no adsorbent with specificity and good biosafety for removing hemoglobin. In this study, a new chitosan/sodium alginate/carbon nitride (CS/SA/CN) hydrogel adsorbent was prepared by blending SA with CN to drop into CS/CaCl solution.
View Article and Find Full Text PDFBackground And Purpose: Airway epithelial cells (AECs) regulate the activation of epithelial-mesenchymal trophic units (EMTUs) during airway remodelling through secretion of signalling mediators. However, the major trigger and the intrinsic pathogenesis of airway remodelling is still obscure.
Experimental Approach: The differing expressed genes in airway epithelia related to airway remodelling were screened and verified by RNA-sequencing and signalling pathway analysis.
Determining the optimal number of emergency medical suppliers for the government to contract with in the context of public health events poses a challenging problem. Having too many suppliers can result in increased costs, while having too few suppliers can potentially expose the government to supply risks. Striking the right balance between these two factors is crucial in ensuring efficient and reliable emergency response and management.
View Article and Find Full Text PDFBackground: Microvascular complications are the major outcome of type 2 diabetes progression, and the underlying mechanism remains to be determined.
Methods: High-throughput RNA sequencing was performed using human monocyte samples from controls and diabetes. The transgenic mice expressing human CTSD (cathepsin D) in the monocytes was constructed using CD68 promoter.
Continuum Landau modes - predicted recently in a non-Hermitian Dirac Hamiltonian under a uniform magnetic field - are continuous bound states with no counterparts in Hermitian systems. However, they have still not been confirmed in experiments. Here, we report an experimental observation of continuum Landau modes in non-Hermitian electric circuits, in which the non-Hermitian Dirac Hamiltonian is simulated by non-reciprocal hoppings and the pseudomagnetic field is introduced by inhomogeneous complex on-site potentials.
View Article and Find Full Text PDFThis study aims to investigate differences in metabolism regarding the transition cows. Eight cows were selected for the test. Serum was collected on antepartum days 14th (ap14) and 7th (ap7) and postpartum days 1st (pp1), 7th (pp7), and 14th (pp14) to detect biochemical parameters.
View Article and Find Full Text PDFSemiconductor materials have become a competitive candidate for surface-enhanced Raman scattering (SERS) substrate. However, powdered semiconductors are difficult to execute a fast in situ detection for trace analytes. Here, we developed a new flexible semiconductor SERS substrate by in situ densely growing anatase TiO nanoparticles on the surface of cotton fabric through a filtration-hydrothermal method, in which TiO exhibits excellent controllability in size and distribution by regulating the ratio of water to alcohol in synthesis and the number of filtration-hydrothermal repetitive cycle.
View Article and Find Full Text PDFCircuits on different layers in a printed circuit board (PCB) must be aligned according to high-precision fiducial mark images during exposure processing. However, processing quality depends on the detection accuracy of fiducial marks. Precise segmentation of fiducial marks from images can significantly improve detection accuracy.
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