Publications by authors named "Xuewei Cao"

Therapeutic approaches combining various treatments have attracted intensive interests for tumor therapy. Nevertheless, these strategies still face many obstacles, such as overexpressed GSH and hypoxia, owing to the intricate tumor microenvironment (TME). Herein, a versatile nanoplatform, CeO@CuO@DOX-RSL3@HA (CCDRH), was initially constructed for promoting the antitumor efficiency regulation of the TME.

View Article and Find Full Text PDF
Article Synopsis
  • A new high-throughput electrochemiluminescence (ECL) method for detecting iodide ions was developed, utilizing a hydrophobic ruthenium derivative mixed with polymer dots to enhance ECL intensity significantly.
  • The enhanced ECL emitters showed 18 times higher intensity than the original polymer dots and 220 times higher than other coreactant-dependent systems, making them highly effective for measurement.
  • This method achieved a notable detection range of 0.8 nM to 4 μM and is particularly valuable for applications in marine monitoring, nuclear security, and cancer treatment due to its specificity and resistance to radiation.
View Article and Find Full Text PDF
Article Synopsis
  • - Most tumors resist treatment with PD-1/PD-L1 inhibitors due to low levels of MHC-I, which affects how tumor cells present antigens to the immune system.
  • - Three plant-derived compounds, platycodin D (PD), polygalacin D, and platycodin D2, were found to significantly lower PD-L1 levels by interacting with liver X receptor β (LXR-β).
  • - Combining PD with nintedanib, a drug that boosts MHC-I expression, improved the ability of T cells to recognize and destroy tumors, shedding light on new treatment strategies.
View Article and Find Full Text PDF

The objective of this study was to develop a physiologically based pharmacokinetic (PBPK) model to predict the concentrations of encapsulated and free doxorubicin in plasma and tissues in mice after intravenous injection of PEGylated liposomes (Doxil). The PBPK model used in this study contains liposomes and free doxorubicin disposition components. The free doxorubicin disposition component was used to simulate the disposition of free doxorubicin produced by mononuclear phagocyte system (MPS)-degrading liposomes.

View Article and Find Full Text PDF
Article Synopsis
  • - The study addresses the issue of missing data in metabolomics, highlighting how integrating whole-genome sequencing (WGS) can improve data accuracy and completeness in analyses.
  • - A new method using a multi-scale variational autoencoder is proposed to impute unknown metabolites by combining genomic data, including polygenic risk scores and SNPs, with metabolomics information.
  • - The results show that this method outperforms traditional imputation techniques, achieving better data imputation rates, which can enhance the understanding of metabolic pathways and their links to diseases.
View Article and Find Full Text PDF

Cell-penetrating peptides (CPPs) with better biomolecule delivery properties will expand their clinical applications. Using the MLCPP2.0 machine algorithm, we screened multiple candidate sequences with potential cellular uptake ability from the nuclear localization signal/nuclear export signal database and verified them through cell-penetrating fluorescent tracing experiments.

View Article and Find Full Text PDF

Joint analysis of multiple correlated phenotypes for genome-wide association studies (GWAS) can identify and interpret pleiotropic loci which are essential to understand pleiotropy in diseases and complex traits. Meanwhile, constructing a network based on associations between phenotypes and genotypes provides a new insight to analyze multiple phenotypes, which can explore whether phenotypes and genotypes might be related to each other at a higher level of cellular and organismal organization. In this paper, we first develop a bipartite signed network by linking phenotypes and genotypes into a Genotype and Phenotype Network (GPN).

View Article and Find Full Text PDF

The susceptibility of lysosomal membranes in tumor cells to cationic amphiphilic drugs (CADs) enables CADs to induce lysosomal membrane permeabilization (LMP) and trigger lysosome-dependent cell death (LDCD), suggesting a potential antitumor therapeutic approach. However, the existence of intrinsic lysosomal damage response mechanisms limits the display of the pharmacological activity of CADs. In this study, we report that low concentrations of QS-21, a saponin with cationic amphiphilicity extracted from tree, can induce LMP but has nontoxicity to tumor cells.

View Article and Find Full Text PDF

Infectious coryza (IC) is an acute infectious respiratory disease in chickens that is caused by Avibacterium paragallinarum (A. paragallinarum). A.

View Article and Find Full Text PDF

Avian influenza virus (AIV) H7N9 diseases have been recently reported, raising concerns about a potential pandemic. Thus, there is an urgent need for effective therapeutics for AIV H7N9 infections. Herein, camelid immunization and yeast two-hybrid techniques were used to identify potent neutralizing nanobodies (Nbs) targeting the H7 subtype hemagglutinin.

View Article and Find Full Text PDF

Topological materials with boundary (surface/edge/hinge) states have attracted tremendous research interest. Additionally, unconventional (obstructed atomic) materials have recently drawn lots of attention owing to their obstructed boundary states. Experimentally, Josephson junctions (JJs) constructed on materials with boundary states produce the peculiar boundary supercurrent, which was utilized as a powerful diagnostic approach.

View Article and Find Full Text PDF
Article Synopsis
  • The text discusses a zoonotic pathogen that affects livestock and leads to significant economic losses in animal husbandry, emphasizing the need for efficient gene manipulation methods to study its function and pathogenesis.
  • A new markerless gene manipulation method was developed using a temperature-sensitive shuttle vector and various selection markers (including a newly constructed screening system) to improve the efficiency of creating genetic mutants in the pathogen.
  • The study shows that the newly created screening system outperforms existing methods, offering valuable tools for understanding the virulence and pathogenic mechanisms of this highly contagious pathogen.
View Article and Find Full Text PDF

Depression is a prevalent mental disorder and has a profound impact on an individual's psychological and physical well-being. It is characterized by a persistently depressed mood, loss of interest, energy loss, and cognitive dysfunction. In recent years, more and more people have changed to mental diseases, such as depression, anxiety, mania and so on.

View Article and Find Full Text PDF

Integration of heterogeneous and high-dimensional multi-omics data is becoming increasingly important in understanding etiology of complex genetic diseases. Each omics technique only provides a limited view of the underlying biological process and integrating heterogeneous omics layers simultaneously would lead to a more comprehensive and detailed understanding of diseases and phenotypes. However, one obstacle faced when performing multi-omics data integration is the existence of unpaired multi-omics data due to instrument sensitivity and cost.

View Article and Find Full Text PDF

Genome-wide association studies (GWAS) have successfully revealed many disease-associated genetic variants. For a case-control study, the adequate power of an association test can be achieved with a large sample size, although genotyping large samples is expensive. A cost-effective strategy to boost power is to integrate external control samples with publicly available genotyped data.

View Article and Find Full Text PDF

Unlabelled: Hip fracture risk assessment is an important but challenging task. Quantitative CT-based patient-specific finite element (FE) analysis (FEA) incorporates bone geometry and bone density in the proximal femur. We developed a global FEA-computed fracture risk index to increase the prediction accuracy of hip fracture incidence.

View Article and Find Full Text PDF

Immunosuppressive tumor microenvironments challenge the effectiveness of protein-based biopharmaceuticals in cancer immunotherapy. Reestablishing tumor cell immunogenicity by enhancing calreticulin (CRT) exposure is expected to improve tumor immunotherapy. Given that CRT translocation is inherently modulated by phosphorylated eIF2α, the selective inhibition of protein phosphatase 1 (PP1) emerges as an effective strategy to augment tumor immunogenicity.

View Article and Find Full Text PDF

Background: Osteoarthritis (OA) is a degenerative joint disease that imposes a significant socioeconomic burden worldwide. Our previous studies revealed a down-regulation of miR-203a-3p in the knee tissues of OA patients. However, the underlying mechanism through which miR-203a-3p mediates the pathological process of OA remains unknown.

View Article and Find Full Text PDF

Background: Hip fracture occurs when an applied force exceeds the force that the proximal femur can support (the fracture load or "strength") and can have devastating consequences with poor functional outcomes. Proximal femoral strengths for specific loading conditions can be computed by subject-specific finite element analysis (FEA) using quantitative computerized tomography (QCT) images. However, the radiation and availability of QCT limit its clinical usability.

View Article and Find Full Text PDF

Background: Metabolomics is a tool to study the pathogenesis of diseases and their associated metabolites, but there are still insufficient metabolomic studies on severe knee osteoarthritis.To investigate the differences in serum metabolites between healthy populations and knee osteoarthritis (KOA) patients in Southern China using widely targeted metabolomics, and to explore biomarkers and their metabolic pathways that could be associated with the severity of KOA.

Methods: There were 10 healthy individuals in the control group and 32 patients with KOA.

View Article and Find Full Text PDF

Motivation: Genome-wide association studies is an essential tool for analyzing associations between phenotypes and single nucleotide polymorphisms (SNPs). Most of binary phenotypes in large biobanks are extremely unbalanced, which leads to inflated type I error rates for many widely used association tests for joint analysis of multiple phenotypes. In this article, we first propose a novel method to construct a Multi-Layer Network (MLN) using individuals with at least one case status among all phenotypes.

View Article and Find Full Text PDF

Background: Missing data is a common challenge in mass spectrometry-based metabolomics, which can lead to biased and incomplete analyses. The integration of whole-genome sequencing (WGS) data with metabolomics data has emerged as a promising approach to enhance the accuracy of data imputation in metabolomics studies.

Method: In this study, we propose a novel method that leverages the information from WGS data and reference metabolites to impute unknown metabolites.

View Article and Find Full Text PDF

Traumatic spinal cord injury (TSCI) is a prevalent central nervous system condition that imposes a significant burden on both families and society, affecting more than 2 million people worldwide. Recently, there has been increasing interest in bone marrow mesenchymal stem cell (BMSC) transplantation as a promising treatment for spinal cord injury (SCI) due to their accessibility and low immunogenicity. However, the mere transplantation of BMSCs has limited capacity to directly participate in the repair of host spinal cord nerve function.

View Article and Find Full Text PDF

Four statistical selection methods for inferring transcription factor (TF)-target gene (TG) pairs were developed by coupling mean squared error (MSE) or Huber loss function, with elastic net (ENET) or least absolute shrinkage and selection operator (Lasso) penalty. Two methods were also developed for inferring pathway gene regulatory networks (GRNs) by combining Huber or MSE loss function with a network (Net)-based penalty. To solve these regressions, we ameliorated an accelerated proximal gradient descent (APGD) algorithm to optimize parameter selection processes, resulting in an equally effective but much faster algorithm than the commonly used convex optimization solver.

View Article and Find Full Text PDF

Nicotinamide adenine dinucleotide (NADH) plays a pivotal role in metabolism. Convenient detection of NADH and its related metabolites has the pursuit of point-of-care and clinical analysis. Here, we propose a polymer dots (Pdots)-based NADH-sensitive electrochemiluminescence (ECL) biosensor for detection of NADH and three metabolites.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionpv1logc4n6lai6mpbulqun9qrjq7uio6): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once