Publications by authors named "Xuesong Ye"

Background: In robot-assisted flexible ureteroscopy, planning a safety-enhanced path facilitates ureteroscope reaching the target safely and quickly. However, current methods rarely consider the safety impact caused by body motion of the anterior part, such as impingement on the lumen wall and sweeping motion risk, or the method can only be used in collision-free situations.

Methods: The kinematic model of the anterior part under C-shaped and S-shaped collision bending is first analysed.

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In the area of human-machine interface research, the continuous estimation of the Center of Pressure (COP) in the human body can assess users' balance conditions, thereby effectively enhancing the safety and diversity of studies. This paper aims to present a novel method for continuous synergy-based estimation of human balance states during walking, and simultaneously analyze the impact of various factors on the estimation results. Specifically, we introduce muscle synergy coherence features and analyze the variations of these features in different balance conditions.

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Accurate prediction of unmeasured muscle excitations can reduce the required wearable surface electromyography (sEMG) sensors, which is a critical factor in the study of physiological measurement. Synergy extrapolation uses synergy excitations as building blocks to reconstruct muscle excitations. However, the practical application of synergy extrapolation is still limited as the extrapolation process utilizes unmeasured muscle excitations it seeks to reconstruct.

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DNA methylation aberrations have a strong correlation with cancer in early detection, diagnosis, and prognosis, which make them possible candidate biomarkers. Electrochemical biosensors offer rapid protocols for detecting DNA methylation status with minimal pretreatment of samples. However, the inevitable presence of background current in the time domain, including electrochemical noise and variations, limits the detection performance of these biosensors, especially for low concentration analytes.

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Purpose: Stereo matching is a crucial technology in the binocular laparoscopic-based surgical navigation systems. In recent years, neural networks have been widely applied to stereo matching and demonstrated outstanding performance. however, this method heavily relies on manual feature engineering meaning that professionals must be involved in the feature extraction and matching.

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Article Synopsis
  • - Colorectal cancer is a serious health issue, and researchers are using computer tools, like convolutional neural networks, to help doctors find early signs of it, such as polyps, during colon exams.
  • - The study introduces a new method called feature pyramid siamese networks (FPSiam) that can learn to detect these polyps using lots of unlabeled videos instead of needing experts to mark them all.
  • - The results show that FPSiam works really well for finding polyps and is more effective than other methods, making it a smart and cost-effective choice for doctors to use in their examinations.
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Objectives: To explore the characteristics of postmortem examination, chemical examination and scene investigation of deaths caused by oral diphenidol hydrochloride poisoning, and so as to provide a reference for proper settlement and prevention of such deaths.

Methods: The data of 22 deaths caused by oral diphenidol hydrochloride poisoning in a city from January 2018 to August 2020 were collected, including case details, scene investigations, autopsies, chemical examinations and digital evidence. Thirty-one cases of deaths caused by oral diphenidol hydrochloride poisoning reported in previous literature were also collected.

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Retrograde intrarenal surgery (RIRS) is a widely utilized diagnostic and therapeutic tool for multiple upper urinary tract pathologies. The image-guided navigation system can assist the surgeon to perform precise surgery by providing the relative position between the lesion and the instrument after the intraoperative image is registered with the preoperative model. However, due to the structural complexity and diversity of multi-branched organs such as kidneys, bronchi, etc.

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Urine analysis is widely used in clinical practice to indicate human heathy status and is important for diagnosing chronic kidney disease (CKD). Ammonium ions (NH), urea, and creatinine metabolites are main clinical indicators in urine analysis of CKD patients. In this paper, NH selective electrodes were prepared using electropolymerized polyaniline-polystyrene sulfonate (PANI: PSS), and urea- and creatinine-sensing electrodes were prepared by modifying urease and creatinine deiminase, respectively.

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The activity and selectivity of the cathode towards electrosynthesis of HO are critical for electro-Fenton process. Herein, nickel-foam modified with N, O co-doped graphite nanosheets (NO-GNSs/Ni-F) was developed as a cathode for highly efficient and selective electrosynthesis of HO. Expectedly, the accumulation of HO at pH= 3 reached 494.

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Endowed with a soft and conductive feature, hydrogels have been widely used as interface materials in bioelectronics to fulfill mechanical matching and bidirectional exchange between electronic platforms and living samples. Despite their ionic conductivity, the lack of electron mobility has limited their further applications in biosensing, especially in the field of electrochemical sensing. Here, we propose a TiC/sodium alginate (SA) hybrid hydrogel with not only a tissue-like mechanical strength (down to 80 kPa) but also a combined exchange interface for ions and electrons, realizing both mechanical and electrical coupling toward biological tissues.

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This study proposed a refined BP prediction strategy that using single-channel photoplethysmography (PPG) signals to stratify populations by cardiovascular status before BP estimation. Combining demographic characteristics (age, gender) and pulse wave morphological features, the random forest was applied to screen two kinds of typical cardiovascular diseases (CVDs), with an accuracy of 92.2%.

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Diabetes has become a leading cause of death and disability in the past decades. Continuous glucose monitoring (CGM) is a prevailing technique to determine the glucose level and provide in-time treatment. However, conventional CGM systems combine an electrochemical sensor with a CMOS chip, suffering from bulky size and interface issues.

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The ankle joint is one of the important joints of the human body to maintain the ability to walk. Diseases such as stroke and ankle osteoarthritis could weaken the body's ability to control joints, causing people's gait to be out of balance. Ankle-foot orthoses can assist users with neuro/muscular or ankle injuries to restore their natural gait.

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Purpose: Flexible ureteroscopy (FURS) plays an important role in the diagnosis and treatment of urological diseases. However, manipulating a flexible ureteroscope to the target quickly and safely may be challenging because of the tortuous lumen or poor visibility. Thus, information on the shape of the anterior part of a flexible ureteroscope in addition to the real-time pose is needed to perform accurate maneuvering in the lumen with minimal impingement on the inner renal wall and resulting tissue damage in FURS.

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The camera is the main sensor of vison-based human activity recognition, and its high-precision calibration of distortion is an important prerequisite of the task. Current studies have shown that multi-parameter model methods achieve higher accuracy than traditional methods in the process of camera calibration. However, these methods need hundreds or even thousands of images to optimize the camera model, which limits their practical use.

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In remote areas, low-pressure ultrafiltration membrane (LPM) systems can be applied in decentralized water supplies for the treatment of groundwater containing Fe, Mn, and NH. However, improving the performance of the LPM systems, such as the stable flux and removal capacity, presents a challenge. In this study, a novel opposite-flow low-pressure ultrafiltration membrane (O-LPM) system was applied, and its performance was evaluated.

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Circular RNA (circRNA) has the potential to be applied to disease diagnosis and therapy. However, the currently available circRNA detection techniques are limited. This work proposes a sensitive and selective approach for circRNA detection based on gold nanoparticle-modified screen-printed magnetic electrodes (AuNPs-SPME).

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MXene based composite conductive aerogels have been extensively investigated as sensitive materials for wearable pressure sensors owing to their effective 3D network microstructures and the excellent conductivity of MXene. In this work, we fabricated a 3D porous TiCT MXene/poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) composite aerogel (MPCA) with a controllable patterning property utilizing the Cu-assisted electrogelation method. The prepared composite aerogel can be assembled into pressure sensors for wearable physical monitoring and high-resolution sensor microarrays for robotic tactile sensing.

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Article Synopsis
  • - Endoscopies play a key role in diagnosing diseases across various medical fields, with biopsies being the standard method for accurate diagnosis.
  • - Traditional random biopsy techniques can lead to sampling errors and delays in diagnosis.
  • - New technologies like endocytoscopy and confocal laser endomicroscopy are being developed for real-time imaging of lesions, offering potential improvements with some limitations still to address.
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Aberrations of genomic DNA methylation have been confirmed to be involved in the evolution of human cancer and have thus gained the potential to be depicted as biomarkers for cancer diagnostics and prognostic predictions, which implicates an urgent need for detection of total genomic DNA methylation. In this work, we suggested an assay for the quantification of global DNA methylation, utilizing methylation specific antibody (5mC) modified magnetic beads (MBs) for immunorecognition and affinity enrichment. Subsequently, the captured DNA on the surface of MBs interacted with the glucose oxidase-conjugated DNA antibody whose catalytic reaction product was engaged in electrochemical detection of the overall level of DNA methylation on a PB-doped screen-printed electrode.

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Levodopa (L-Dopa) is considered to be one of the most effective therapies available for Parkinson's disease (PD) treatment. The therapeutic window of L-Dopa is narrow due to its short half-life, and long-time L-Dopa treatment will cause some side effects such as dyskinesias, psychosis, and orthostatic hypotension. Therefore, it is of great significance to monitor the dynamic concentration of L-Dopa for PD patients with wearable biosensors to reduce the risk of complications.

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Gastric disease is a major health problem worldwide. Gastroscopy is the main method and the gold standard used to screen and diagnose many gastric diseases. However, several factors, such as the experience and fatigue of endoscopists, limit its performance.

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Simultaneous monitoring of electrophysiological and biochemical signals is of great importance in healthcare and fitness management, while the fabrication of highly integrated and flexible devices is crucial to these applications. Herein, we devised a multifunctional and flexible hydrogel-paper patch (HPP) that was capable of simultaneously real-time monitoring of electrocardiogram (ECG) signal and biochemical signal (glucose content) in sweat during exercise. The self-assembly of the highly porous PEDOT:PSS hydrogel on paper fiber provided the HPP with good conductivity and hydrophilic wettability for efficient electron transmission and substance diffusion, thereby enabling it to serve as a low-impedance ECG electrode and a highly sensitive glucose sensor.

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Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death. Circ-CDYL, one of the circular RNAs (circRNAs), is recognized as an independent marker for HCC early diagnosis. Point-of-care testing (POCT) of circRNA is essential and in great demand for clinical applications.

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