Positive feedback loop of c-myc/XTP6/NDH2/NF-κB to promote malignant progression in glioblastoma.

Background: Recent studies have highlighted the significant role of the NF-κB signaling pathway in the initiation and progression of cancer. Furthermore, long noncoding RNAs (lncRNAs) have been identified as pivotal regulators in sustaining the NF-κB signaling pathway's functionality. Despite these findings, the underlying molecular mechanisms through which lncRNAs influence the NF-κB pathway remain largely unexplored.

Development and clinical evaluation of an online automated quality control system for improving laboratory quality management.

Background: We developed an efficient online automated quality control (AUTO QC) system and tested its feasibility on automatic laboratory assembly lines.

Methods: AUTO QC is based on developed quality control software (Smart QC) and designed adaptable consumables before. We applied the system to two assembly lines in our laboratory.

Gain-loss situation modulates neural responses to self-other decision making under risk.

Although self-other behavioral differences in decision making under risk have been observed in some contexts, little is known about the neural mechanisms underlying such differences. Using functional magnetic resonance imaging (fMRI) and the cups task, in which participants choose between risky and sure options for themselves and others in gain and loss situations, we found that people were more risk-taking when making decisions for themselves than for others in loss situations but were equally risk-averse in gain situations. Significantly stronger activations were observed in the dorsomedial prefrontal cortex (dmPFC) and anterior insula (AI) when making decisions for the self than for others in loss situations but not in gain situations.

Self-Other Differences in Decision-Making Under Risk.

Decisions made for others reflect not only decision-makers' cognitive and emotional states but also decision-makers' interpersonal concerns. People who make choices for others will potentially be blamed for unappealing outcomes by others. Therefore, we hypothesize that individuals will seek sure gains (which increase individuals' responsibility for desirable outcomes) and avoid sure losses (which decrease individuals' responsibility for undesirable outcomes) when making risky decisions for others more than when making such decisions for themselves.

Negative Differential Conductance in Polyporphyrin Oligomers with Nonlinear Backbones.

We study negative differential conductance (NDC) effects in polyporphyrin oligomers with nonlinear backbones. Using a low-temperature scanning tunneling microscope, we selectively controlled the charge transport path in single oligomer wires. We observed robust NDC when charge passed through a T-shape junction, bistable NDC when charge passed through a 90° kink and no NDC when charge passed through a 120° kink.

Decisions for Others Are Less Risk-Averse in the Gain Frame and Less Risk-Seeking in the Loss Frame Than Decisions for the Self.

Despite the fact that people make decisions for others as often as they make decisions for themselves, little is known about how decisions for others are different from those made for the self. In two experiments, we investigated the effect of social distance (i.e.

Single-Molecule Investigations of Conformation Adaptation of Porphyrins on Surfaces.

The porphyrin macrocyclic core features dynamic conformational transformations in free space because of its structural flexibility. Once attached to a substrate, the molecule-substrate interaction often restricts this flexibility and stabilizes the porphyrin in a specific conformation. Here using molecular dynamic and density-functional theory simulations and scanning tunneling microscopy and spectroscopy, we investigated the conformation relaxation and stabilization processes of two porphyrin derivatives (5,15-dibromophenyl-10,20-diphenylporphyrin, BrTPP, and 5,15-diphenylporphyrin, DPP) adsorbed on Au(111) and Pb(111) surfaces.

Resonant Charge Transport in Conjugated Molecular Wires beyond 10 nm Range.

Using a scanning tunneling microscope, we measured high-bias conductance of single polyporphyrin molecular wires with lengths from 1.3 to 13 nm. We observed several remarkable transport characteristics, including multiple sharp conductance peaks, conductances as high as 20 nS in wires with lengths of >10 nm, and nearly length-independent conductance (attenuation <0.

Effects of municipal sewage sludge stabilized by fly ash on the growth of Manilagrass and transfer of heavy metals.

A greenhouse experiment was carried out to evaluate the feasibility of using an artificial soil for cultivation of Manilagrass. The transfer and transformation of heavy metals in the artificial soil-Manilagrass system were discussed at the same time. The results showed that fly ash-sludge indicated a positive effect on the growth of Manilagrass.