Publications by authors named "Xuesong Ma"

Article Synopsis
  • Pomalidomide, a stronger drug than thalidomide, could help treat lung cancer when combined with other drugs.
  • Researchers found that it targets an important enzyme called ETFA, which helps produce energy in cancer cells.
  • The study suggests that by boosting energy production, pomalidomide helps make cancer cells more likely to die, especially when used with a drug called cisplatin.
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Alfalfa ( L.) is an important forage legume and soil salinization seriously affects its growth and yield. In a previous study, we identified a salt-tolerant variety 'Gongnong NO.

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  • Targeting polo-box domain (PBD) of polo-like kinase 1 (PLK1) presents a promising strategy to inhibit cancer growth without the side effects associated with traditional ATP-competitive inhibitors.
  • A high-throughput virtual screening led to the discovery of compound 1a, followed by the development of a more effective derivative, compound 4Bb, which has a K value of 0.29 μM and inhibits PLK1 activity, disrupting crucial interactions in lung cancer cells.
  • The compound 4Bb not only shows strong cytotoxicity against various cancer cells by disturbing redox balance but also effectively reduces tumor growth in vivo, significantly increasing survival rates in treated mice while sparing normal tissue from toxicity.
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The recycling of spent lithium-ion batteries (LIBs) has attracted great attention, mainly because of its significant impact on resource recycling and environmental protection. Currently, the processes involved in recovering valuable metals from spent LIBs have shown remarkable progress, but little attention has been paid to the effective separation of spent cathode and anode materials. Significantly, it not only can reduce the difficulty in the subsequent processing of spent cathode materials, but also contribute to the recovery of graphite.

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In this work, pH-sensitive blue fluorescent carbon dots (CDs) with high fluorescence quantum yield (17.24%) were synthesized by hydrothermal method using Toona sinensis leaves and ethylenediamine (EDA) as raw materials. The CDs can detect urea with a limit of detection (LOD) of 6.

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In this work, a new sustainable melamine detection method was developed. Biomass-derived carbon dots (CDs) were successfully prepared by ionic liquid (1-Allyl-3-methylimidazolium chloride, IL) hydrothermal method using agricultural waste corn cob as the carbon source, and combined with silver nanoparticles (AgNPs) to construct fluorescent probe CDs@IL-AgNPs. The probe was characterized and the formation mechanism of the probe was discussed.

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  • * MX-C4 effectively promotes the phosphorylation of p53 and demonstrates strong antitumor effects in various cancer cell lines while showing low toxicity in p53-null and normal cells.
  • * Mechanistically, MX-C4 activates p53, leading to cell cycle arrest and apoptosis, and shows potential for use in EGFR-driven lung cancer models with minimal side effects.
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Objective: The aim of this study was to explore the current status of the anaesthesia provision, infrastructure and resources in the Heilongjiang Province, China.

Design: A cross-sectional observational study of hospitals, anaesthesiologists, assistant anaesthesiologists and anaesthetic nurses in the Heilongjiang Province.

Setting: All hospitals in the Heilongjiang Province.

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  • BCL-X-selective inhibitors show potential when combined with chemotherapy for treating solid tumors, but their standalone efficacy is low due to issues with functioning in cancerous environments.
  • The research identified that ineffective mitochondrial entry of these inhibitors, A-1155463 and A-1331852, leads to their reduced effectiveness in non-small-cell lung cancer (NSCLC) cells.
  • A new small molecule, NA-2a, enhances the action of A-1331852 by improving its mitochondrial uptake, which disrupts the BCL-X protein complex, ultimately increasing its anticancer properties.
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A simple and novel approach is proposed to represent the mutual solubility of water and hydrocarbon components based on equations of state at high temperatures in thermal recovery processes. Sϕreide and Whitson modifications are applied to the Peng-Robinson (PR) equation of state (EOS) so that all components, including the water component, can exist in all phases, reasonably representing gas solubility in water and water solubility in hydrocarbon phases. We propose an algorithm to assign binary interaction parameters (BIPs) for aqueous and nonaqueous phases.

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Non-invasive positive pressure ventilation has attracted increasing attention for air management in general anesthesia. This work proposes a novel robot equipped with two snake arms and a mask-fastening mechanism to facilitate trachea airway management for anesthesia as well as deep sedation and to improve surgical outcomes. The two snake arms with supporting terminals have been designed to lift a patient's jaw with design optimization, and the mask-fastening mechanism has been utilized to fasten the mask onto a patient's face.

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Agricultural tillage practices significantly affect the structure and function of soil micro-bial community, as well as its control over soil carbon cycling. Conservation tillage practice based on no-tillage and crop straw returning is an important measure to improve soil carbon sequestration and fertility, in which soil microorganisms play a key role. Although many previous studies focus on the structure and function of microbial communities under conservation tillage, our overall understanding of soil microbial responses at community level upon conservation tillage is still lacking, due to the complexity of the soil, environmental factors and the different selections of microbial research methods.

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Alfalfa ( L.) is an important forage crop, and salt stress is a major limiting factor in its yield. Melatonin (MT) is a multi-regulatory molecule in plants.

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Foodborne protein hydrolysates exhibit biological activity that may be therapeutic in a number of human disease settings. Hemp peptides (HP) generated by controlled hydrolysis of hemp proteins have a number of health benefits and are of pharmaceutical value. In the present study, we produce small molecular weight HP from hemp seed and investigate its anticancer properties in Hep3B human liver cancer cells.

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Abscission, a cell separation process, is an important trait that influences grain and fruit yield. We previously reported that BEL1-LIKE HOMEODOMAIN 4 (SlBL4) is involved in chloroplast development and cell wall metabolism in tomato fruit. In the present study, we showed that silencing SlBL4 resulted in the enlargement and pre-abscission of the tomato (Solanum lycopersicum cv.

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Orobanche cumana is a holoparasitic plant that attaches to host-plant roots and seriously reduces the yield of sunflower (Helianthus annuus L.). Effective control methods are lacking with only a few known sources of genetic resistance.

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Study Question: How is the activation of estrogen receptor β (ERβ) in endometriotic stromal cells (ESCs) involved in macrophage recruitment to promote the pathogenesis of endometriosis?

Summary Answer: ERβ modulates the production of C-C motif chemokine ligand 2 (CCL2) via nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling in ESCs and thus recruits macrophages to ectopic lesions to promote pathogenesis.

What Is Known Already: Macrophages are mainly recruited to the peritoneal cavity to promote the pathogenesis of endometriosis. Recent studies have demonstrated that ERβ plays an important role in the progression of endometriosis through modulating apoptosis and inflammation.

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Background: A right-sided double-lumen tube (R-DLT) tends to obstruct the right upper lobe intraoperatively due to anatomical distortion during surgery. If the R-DLT is poorly matched with the patient's airway anatomy, it will not be possible to correctly replace the tube with a fiberoptic bronchoscope (FOB). In our study, we aimed to explore an efficient method for difficult repositioning caused by right upper lobe occlusion during surgery: repositioning the R-DLT from the right main bronchus into the left main bronchus.

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Background: Long non-coding RNA growth arrest-specific transcript 5 (lncRNA GAS5) is a well-known tumor suppressor in the pathogenesis of a variety of human cancers. The precise role of GAS5 in pancreatic cancer (PC) progression is currently unknown, so the aim of this study was to explore the functional participation of GAS5 in PC metastasis.

Methods: The expression changes of GAS5, miR-32-5p and PTEN in human PC specimens and cell lines were compared by means of molecular biology methods.

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Objective: To explore the core mechanism of long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) in the regulation of multidrug resistance of pancreatic cancer cells.

Methods: mRNA levels of GAS5, miR-181c-5p and Hippo pathway related genes were detected by quantitative real-time PCR (qRT-PCR). Protein levels of MDR-1, MST1, YAP and TAZ were measured by western blot.

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When given prior to brain ischemia, mitochondrial division inhibitor-1 (mdivi-1) attenuates the brain damage caused by ischemia. Here, we investigated the potential effects of post-ischemia mdivi-1 treatment (1mg/kg, i.p.

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Background: To explore the predictive performance of the newly established visceral adiposity index for diabetes and prediabetes, as well as the relationships between the visceral adiposity index and the parameters of insulin secretion and action.

Methods: Eight hundred twenty-four first-degree relatives of individuals with type 2 diabetes who had no known history of abnormal glucose regulation were selected. Diabetes and prediabetes were diagnosed using the standard oral glucose tolerance test.

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Objective: To investigate the effects of dexmedetomidine combined with fentanyl in patients undergoing anesthesia induction by sevoflurane.

Method: Eighty patients for elective endotracheal intubation under general anesthesia operations were randomly and double-blindly divided into Dex combined with fentanyl group (Group DF) and the fentanyl group (Group F) from April 2011 to September 2011 at the Fourth Affiliated Hospital of Harbin Medical University, and there were 40 cases in each group. The investigation was approved by all the patients and by the Ethics Committee of the hospital.

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Background And Purpose: Mitochondrial dysfunction has been implicated in the cell death observed after cerebral ischemia, and several mechanisms for this dysfunction have been proposed. Reperfusion after transient cerebral ischemia may cause continued and even more severe damage to the brain. Many lines of evidence have shown that mitochondria suffer severe damage in response to ischemic injury.

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Background: Rapid socioeconomic development resulting in changing lifestyles and life expectancy appears to be accompanied by an increasing prevalence of type 2 diabetes. Genetic predisposition related to ethnicity is a major determinant of diabetes risk. This study investigates the prevalences of diabetes and prediabetes in different ethnic populations residing in the Mudanjiang area located in the northeast of China.

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