Targeting the ZNF-148/miR-335/SOD2 signaling cascade triggers oxidative stress-mediated pyroptosis and suppresses breast cancer progression.

Background: The implication of zinc finger protein 148 (ZNF-148) in pathophysiology of most human cancers has been reported; however, the biological functions of ZNF-148 in breast cancer remain unclear. This study sought to elucidate the potential molecular mechanism of ZNF-148 on breast cancer pathology.

Methods: ZNF148 expression was tested in breast cancer tissues and cells.

The Controlled Compound Layer of Ni-Coated Nitrided Pure Iron.

In order not to sacrifice nitrided layer thickness and reduce brittle compound layer thickness, Ni-coated pretreatment was carried out with electrodeposition on a pure iron surface, followed by gas nitriding. The brittle compound layer thickness of duplex surface treated samples was reduced, and the nitrided layer thickness increased to 320 μm. The microhardness was 4 times harder, and the wear loss was reduced by 68% compared with the original material.

Facile synthesis of ternary flexible silica aerogels with coarsened skeleton for oil-water separation.

Ternary flexible silica aerogels were synthesized using a facile sol-gel process without solvent exchange and surface modification using dimethyldiethoxysilane (DEDMS), methyltriethoxysilane (MTES) and tetraethoxysilane (TEOS) ambient pressure drying. The skeleton morphology of the aerogels was precisely controlled by the DEDMS/TEOS molar ratio (D). The effect of the morphology of the aerogel skeleton on the mechanical properties and the adsorption capacity was investigated.