A Strong-Acid-Resistant [Th ] Cluster-Based Framework for Effectively and Size-Selectively Catalyzing Reductive Amination of Aldehydes with N,N-Dimethylformamide.

Utilization of N,N-dimethylformamide (DMF) as an amine source and reductant for synthesizing tertiary amines is a promising way to replace the substrates formaldehyde and dimethylamine, and it is desirable to seek porous acid-resistant catalysts for heterogeneous catalysis of this reaction. Herein, a robust metal-organic framework (MOF) {[Th O (OH) (H O) (BCP) ]⋅10 DMF} (1) containing stacked nanocages with a diameter of 1.55 nm was constructed.

Selectively Regulating Lewis Acid-Base Sites in Metal-Organic Frameworks for Achieving Turn-On/Off of the Catalytic Activity in Different CO Reactions.

Regulating Lewis acid-base sites in catalysts to investigate their influence in the chemical fixation of CO is significant but challenging. A metal-organic framework (MOF) with open metal Co sites, {(NH Me )[Co (μ -OH)(BTB) (H O)]⋅9 H O⋅5 DMF} (1), was obtained and the results of the catalytic investigation show that 1 can catalyze cycloaddition of CO and aziridines to give 99 % yield. The efficiency of the cyclization of CO with propargyl amines is only 32 %.

Efficient Cycloaddition of CO and Aziridines Activated by a Quadruple-Interpenetrated Indium-Organic Framework as a Recyclable Catalyst.

On the basis of the global warming effect, it is of great significance to convert CO into the high value-added products oxazolidinones, but investigations on main-group-based metal-organic frameworks (MOFs) as heterogeneous catalysts still have not been reported so far. In this work, a quadruple-interpenetrated porous indium-based MOF, {[NH(CH)][In(CPT)]·3CHCN·3DMA} (), is constructed from the organic ligand 3,5-bis(4'-carboxyphenyl)-1,2,4-triazole through solvothermal reactions, and N adsorption proves that the framework has a high Brunauer-Emmett-Teller surface areas with 2024 m/g. The catalytic research on CO conversion reveals that compound has high reactivity for the cycloaddition of CO with aziridines, and the product 3-ethyl-5-phenyloxazolidin-2-one can be obtained with a yield of 99% under mild conditions.

Hypoxia-induced MFAP5 Promotes Tumor Migration and Invasion via AKT Pathway in Head and Neck Squamous Cell Carcinoma.

: Microfibrillar-associated protein 5 (MFAP5) is highly expressed in many types of cancers. Our previous study has observed that overexpression of MFAP5 was correlated with lymph nodes metastasis and poor prognosis in head and neck squamous cell carcinoma (HNSCC), but the underlying mechanism is poorly understood. : The MFAP5 expression is detected under hypoxia condition.

Crystal structures of hybrid completely reduced phosphomolybdates and catalytic performance applied as molecular catalysts for the reduction of chromium(VI).

The exploration of highly efficient and low-cost catalysts for the treatment of hexavalent chromium Cr in environmental remediation is currently one of the most challenging topics. Here, three phosphomolybdate hybrid compounds have been successfully isolated by the hydrothermal method and been applied as supramolecular catalysts for the reduction of Cr. Single-crystal X-ray diffraction revealed their formulae as (Hbpp)[Fe(HO)][Sr(HO)]{Fe[MoO(OH)(HPO)(HPO)(PO)]}·5HO (1), (Hbpp)[Na(HO)(OCH)][Fe(HO)][Ca(HO)]{Fe[MoO(OH)(HPO)(HPO)(PO)]}·4HO (2) and (Hbpe){Fe[MoO(OH)(HPO)(HPO)]}·8HO (3) [bpp is 1,3-bis(pyridin-4-yl)propane (CHN) and bpe is trans-1,2-bis(pyridin-4-yl)ethylene (CHN)].

Novel fully reduced phosphomolybdates for highly efficient removal of inorganic hexavalent chromium and the organic dye methylene blue.

New Na-bridged phosphomolybdates (H2en)12[{Na0.8K0.2(H2O)}2{Na[Mo6O12(OH)3(HPO4)2(PO4)2]2}2]·7H2O (1), (H2bpp)2[{Sr2(H2O)4}{Na3(H2O)10}{Na[Mo6O12(OH)3(HPO4)3(PO4)]2}]·2H2O (2), and (H2bpp)6 [{Ca2(H2O)4}{Na2(H2O)4}{Na[Mo6O12(OH)3(HPO4)3(PO4)]2}2] (3) (en = ethylenediamine, bpp = 1,3-bi(4-pyridyl)propane), were synthesized by a hydrothermal method and characterized.

Synthesis of Hybrid Phosphomolybdates and Application as Highly Stable and Effective Catalyst for the Reduction of Cr(VI).

Three hybrid phosphomolybdates were successfully synthesized by hydrothermal method and characterized by a series of physicochemical analysis techniques. X-ray single-crystal structural analysis revealed that three compounds with the reductive polyanionic clusters (Mo) were wrapped by protonated organic component bpp cations (bpp = 1,3-bi(4-pyridyl)propane) through the complex supramolecular hydrogen bonding network. They also have similar molecular formulas: (Hbpp)[PbM(HO)]H{M[MoO(OH)(HPO)(PO)]}· nHO (M = Fe in 1, Zn in 2, n = 4; or M = Mn in 3, n = 6).

Prognostic impact of perineural invasion in early stage oral tongue squamous cell carcinoma: Results from a prospective randomized trial.

Background: Although perineural invasion (PNI) has been recognized as a poor prognostic factor for oral cancer, few studies have focused on tongue squamous cell carcinoma (TSCC). Using a prospective randomized trial, this study investigated the role of PNI in the regional control and survival of the patients with cT1-2N0 TSCC, and clarified the benefit of neck management based on PNI status.

Methods: PNI status was reviewed under H&E staining in tumors of 221 patients with cT1-2N0 TSCC, who were randomly assigned into elective neck dissection (END) group (n = 111) and observation group (n = 110).

MFAP5 and TNNC1: Potential markers for predicting occult cervical lymphatic metastasis and prognosis in early stage tongue cancer.

The purpose of this study is to identify candidate genes that could predict prognosis of early-stage tongue squamous cell carcinoma (TSCC) and its occult cervical lymphatic metastasis by large-scale gene expression profiling. Tumor tissue and matched normal mucosa samples were collected from patients with TSCC and analyzed with Affymetrix HTA2.0 high-density oligonucleotide array.