Publications by authors named "Xuerui Tang"
The wide range of applications and the enormous production of nanomaterials have raised the possibility that humans may simultaneously contact with various nanomaterials through multiple routes. Although numerous toxicity studies have been conducted on the toxicity of nanomaterials, knowledge of the combined toxicity of nanomaterials remains limited. Herein, the combined toxic effects of the two types of the most widely used nanomaterials, silver and silica, were studied on HeLa cells.
View Article and Find Full Text PDFHow big nanoparticles carry small ones into cells: Actions captured by transmission electron microscopy.
Colloids Surf B Biointerfaces
January 2025
Article Synopsis
- - The study investigates how the size of nanoparticles (NPs) affects their uptake by cells, revealing that larger NPs (100 nm) can enhance the uptake of smaller NPs (50 nm) when both are present.
- - Using transmission electron microscopy (TEM), researchers discovered a size threshold for triggering clathrin-mediated endocytosis, where one SNP100 can efficiently facilitate the uptake of about six SNP50.
- - These findings suggest that combining different sized NPs can improve drug delivery systems and highlight potential risks in nanotoxicity evaluations, as seen when a mixture of SNP100 and catalase-functionalized SNP50 caused greater cell damage.
Article Synopsis
- Gastric cancer (GC) ranks as the 5th most common cancer and 4th leading cause of cancer-related deaths worldwide, with FTO identified as a key player in its development due to its role as an m6A demethylase.
- In this study, researchers found that FTO levels are significantly higher in GC tissues and cells, correlating with more severe disease characteristics and worse patient outcomes.
- The study reveals that FTO enhances GC cell growth and movement by affecting specific proteins in a signaling pathway, suggesting its potential as a biomarker for diagnosing and predicting treatment responses in GC patients.
Impact of calcium ions at physiological concentrations on the adsorption behavior of proteins on silica nanoparticles.
J Colloid Interface Sci
February 2024
The adsorption of proteins on nanoparticles (NPs) largely decides the fate and bioeffects of NPs in vivo. However, bio-fluids are too complicated to directly study in them to reveal related mechanisms, and current studies on model systems often ignore some important biological factors, such as metal ions. Herein, we evaluate the effect of Ca at physiological concentrations on the protein adsorption on negatively-charged silica NP (SNP50).
View Article and Find Full Text PDFGastric cancer (GC) is a prevalent digestive tract malignant tumor characterized by an insidious onset, ease of metastasis, rapid growth, and poor prognosis. Here, we report that fibronectin type III domain containing 1 (FNDC1) has high expression in GC and indicates poor outcomes in patients with GC. FNDC1 over-expression or knockdown promotes or inhibits tumorigenesis and metastasis, respectively.
View Article and Find Full Text PDFEndocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells.
Nanomaterials (Basel)
December 2022
Nanoplastics, one component of plastic pollution, can enter human bodies via inhalation and thus threaten human health. However, the knowledge about the uptake and exocytosis of nanoplastics in cells of human lung organs is still very limited. Herein, we investigated the endocytosis, distribution, and exocytosis of polystyrene nanoparticles (PS NPs) of 50 nm (G50PS) and 100 nm (R100PS) in A549 cells and BEAS-2B cells.
View Article and Find Full Text PDFCervical cancer (CC) is a severe malignant tumor. Recently, more and more evidence has shown that abnormal expression of fatty acid synthase (FASN) occurs in varying tumors. Therefore, this investigation devoted to FASN in CC along with its upstream regulatory miRNA.
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