Publications by authors named "Xueru Xie"
The aryl hydrocarbon receptor (AhR) functions in the regulation of intestinal inflammation, but knowledge of the underlying mechanisms in innate immune cells is limited. Here, we investigated the role of AhR in modulating the functions of macrophages in inflammatory bowel disease pathogenesis. The cellular composition of intestinal lamina propria CD45 leukocytes in a dextran sulfate sodium (DSS)-induced mouse colitis model was determined by single-cell RNA sequencing.
View Article and Find Full Text PDFArticle Synopsis
- N-methyladenosine (mA) is a common mRNA modification that plays a key role in various biological processes, but its role in allergic asthma and macrophage function is not well understood.* -
- The study finds that low levels of METTL3, the enzyme that adds mA, in macrophages from childhood asthma patients lead to increased Th2 responses and worse allergic inflammation due to enhanced M2 macrophage activation.* -
- METTL3's regulation of M2 macrophage activation involves specific signaling pathways and affects PTX3 mRNA stability, linking mA modification to macrophage function and potential new avenues for asthma treatment.*
Article Synopsis
- - Zinc and plant-derived ligands that activate the aryl hydrocarbon receptor (AHR) play a role in improving the gut barrier function and might protect against inflammatory bowel disease.
- - In experiments with mice, AHR ligands were effective in supporting gut health, but only if the mice had functional AHR and weren't on a zinc-deficient diet.
- - The study found that activating AHR can increase cellular zinc levels, which helps upregulate important proteins that strengthen intestinal barriers, indicating that combining diets rich in AHR ligands and zinc could be beneficial for gut health.
Background: Dysregulation of circRNAs is associated with a variety of human diseases; however, its role in childhood asthma is undefined.
Methods: The differential expression profiles of circRNAs were analyzed by microarray. The effects and mechanisms by which circRNAs influence macrophage activation were detected by quantitative real-time PCR, RNA immunoprecipitation assay, and chromatin immunoprecipitation assay, among others.
Correction: The signal pathways and treatment of cytokine storm in COVID-19.
Signal Transduct Target Ther
August 2021
The signal pathways and treatment of cytokine storm in COVID-19.
Signal Transduct Target Ther
July 2021
Article Synopsis
- The COVID-19 pandemic has significantly impacted global health, economy, and society, presenting unique challenges compared to previous infectious diseases.
- Current research highlights immunopathology's role in COVID-19, particularly cytokine storms (CS), which involve excessive production of pro-inflammatory cytokines and can lead to severe medical complications.
- Understanding CS's initiation and signaling pathways is vital for developing effective treatments for COVID-19 and similar inflammatory diseases.