Publications by authors named "Xueru Fu"

Aim: The aim was to examine the relationship between exposure to environmental metallic and metalloid pollutants and cardiovascular disease (CVD) and all-cause mortality by integrating the information currently available from systematic reviews and meta-analyses.

Method: PubMed, Embase, and Web of Science for systematic reviews and meta-analyses were thoroughly searched up to October 9, 2024. Systematic reviews and meta-analyses of various kinds that evaluated the relationship between exposure to ambient metallic and metalloid pollutants and CVD and all-cause mortality were included.

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Background And Aims: Although existing evidence suggests that arterial stiffness and obesity impact cardiovascular health, limited studies have been conducted to explore the association between brachial-ankle pulse wave velocity (baPWV), obesity-related indices, and the risk of atherosclerotic cardiovascular disease (ASCVD).

Methods And Results: The study participants were among those who completed the baPWV measurement at the second follow-up examination (during 2018-2020) of the Rural Chinese Cohort Study. Logistic regression models were employed to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) of the 10-year incident risk score of ASCVD associated with baPWV and obesity-related indices.

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Purpose: Our study aimed to identify the trajectory patterns of lipid accumulation product (LAP) and investigate their association with the incident risk of type 2 diabetes mellitus (T2DM) in China.

Methods: This study included 37,316 eligible participants, with data collected between1998 and 2021. The LAP trajectory patterns were identified through latent mixture modeling.

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Article Synopsis
  • A systematic review and meta-analysis investigated the relationship between mitochondrial DNA copy number (mtDNA-CN) and cardiovascular disease (CVD), revealing mixed findings in studies prior to October 2023.
  • The analysis included 22 articles, with key findings indicating that lower mtDNA-CN levels significantly increased the risk of various cardiovascular issues and overall mortality.
  • Specifically, the lowest mtDNA-CN correlated with a 2.09 times increased risk of CVD, suggesting that mtDNA-CN could serve as a potential predictor for cardiovascular problems and all-cause mortality.
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Aims: This study aimed to identify the distinct change trajectories of the Chinese visceral adiposity index (CVAI) over time and to investigate their associations with risk of type 2 diabetes mellitus (T2DM).

Materials And Methods: This study included 52 394 participants from the prospective project, the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR). The CVAI was calculated using measures of age, body mass index, waist circumference, triglycerides and high-density lipoprotein cholesterol.

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Objective: In order to assess the associations between telomere length (TL) and diabetes mellitus (DM), especially type 2 diabetes (T2DM), we performed this systematic review and meta-analysis.

Methods: PubMed, Embase, and Web of Science were thoroughly searched up to July 11, 2023. The pooled standardized mean difference (SMD) and the 95% confidence interval (CI) were evaluated using the random-effects model.

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Article Synopsis
  • The study explored the links between two insulin resistance indicators, the triglyceride to HDL cholesterol (TG/HDL-C) ratio and the triglyceride-glucose (TyG) index, and the risk of arterial stiffness in a group of 1,979 participants from a rural Chinese study.! -
  • Findings revealed that increases in both TG/HDL-C and TyG were significantly associated with higher arterial stiffness, as measured by brachial-ankle pulse wave velocity (baPWV) using statistical models and meta-analysis.! -
  • The results suggest that higher levels of TG/HDL-C and TyG can serve as important predictors for arterial stiffness, highlighting their potential role in assessing cardiovascular health risks.!
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Our aim was to examine the independent and joint associations of estimated cardiorespiratory fitness (CRF) and its changes and obesity with risk of hypertension in a rural Chinese population. A prospective cohort including 9848 adults without hypertension at baseline was enrolled. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated by logistic regression models.

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  • The study aimed to explore the relationship between olive oil intake and various health outcomes, including cardiovascular disease (CVD), coronary heart disease (CHD), stroke, and cancer.
  • It included a meta-analysis of 30 articles with over 2.7 million participants, showing that higher olive oil consumption is associated with a reduced risk of CVD incidents, CHD incidents, and CVD mortality.
  • While olive oil intake seemed beneficial for CVD-related issues, there was no significant link found between olive oil and cancer incidence or mortality.
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  • This meta-analysis examines the connection between pregnancy loss, specifically miscarriages and stillbirths, and the risk of cardiovascular diseases (CVDs).
  • The study analyzed 23 articles and found that women with a history of miscarriage had higher pooled relative risks for various CVDs, with risks increasing for each additional miscarriage.
  • Similarly, women with stillbirths showed even greater risks for total CVDs and related conditions, indicating a significant association between pregnancy loss and cardiovascular health.
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Our study aimed to investigate the association between the transition of the TXNIP gene methylation level and the risk of incident type 2 diabetes mellitus (T2DM). This study included 263 incident cases of T2DM and 263 matched non-T2DM participants. According to the methylation levels of five loci (CpG1-5; chr1:145441102-145442001) on the TXNIP gene, the participants were classified into four transition groups: maintained low, low to high, high to low, and maintained high methylation levels.

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Aims: To identify the trajectories of body mass index (BMI) and waist circumference (WC), and assess the associations of BMI trajectory, WC trajectory, or the two combined, with type 2 diabetes mellitus (T2DM) risk in Chinese adults.

Materials And Methods: This study was based on a prospective project-the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR). A total of 54 434 participants (39.

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Purpose: This meta-analysis evaluated the relationship between overweight/obesity and depressive disorders in children and adolescents.

Methods: We examined the databases of PubMed, Embase and Web of Science for pertinent observational studies released up until 20 February 2022. The pooled relative risks (RRs) and 95% confidence intervals (CIs) of obesity and overweight with depressive disorder were calculated by means of random-effects models.

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Background: Accumulating studies indicate that maternal obesity is associated with the risk of cerebral palsy (CP); however, their conclusions have been inconsistent.

Objectives: To quantitatively estimate the association between maternal body mass index (BMI) and CP in offspring.

Data Sources: PubMed, Embase and Web of Science.

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Article Synopsis
  • - The study aimed to explore how a methylation risk score (MRS) relates to the risk of type 2 diabetes mellitus (T2DM) and how environmental factors might interact with this score.
  • - Researchers conducted a nested case-control study involving 241 individuals with T2DM and 241 matched controls, analyzing specific genetic methylation sites to create simple and weighted MRSs.
  • - Results showed that higher MRSs were significantly linked to increased T2DM risk, with specific interactions found between smoking, hypertension, and obesity, indicating environmental factors may affect this relationship.
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While noise pollution from transportation has become an important public health problem, the relationships between different sources of traffic noise and cardiovascular diseases (CVDs) remain inconclusive. A comprehensive meta-analysis was therefore conducted to quantitatively assess the effects of long-term exposure to road traffic, railway, and aircraft noise on CVDs and relevant subtypes. We systematically retrieved PubMed, Embase, and Web of Science for articles published before April 4, 2022.

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We sought to explore the association between heavy metal exposure and coronary heart disease (CHD) based on data from the US National Health and Nutrition Examination Survey (NHANES, 2003-2018). In the analyses, participants were all aged > 20 and had participated in heavy metal sub-tests with valid CHD status. The Mann-Kendall test was employed to assess the trends in heavy metals' exposure and the trends in CHD prevalence over 16 years.

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Alcohol consumption remains inconsistently correlated with fracture risk, and a dose-response meta-analysis for specific outcomes is lacking. The objective of this study was to quantitatively integrate the data on the relationship between alcohol consumption and fracture risk. Pertinent articles were identified in PubMed, Web of Science, and Embase databases up to 20 February 2022.

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To examine the independent and joint associations of dietary inflammation index (DII) and physical activity (PA) with mortality risk. We analyzed data for 20,165 study participants aged ≥ 18 from The Rural Chinese Cohort Study. The Cox proportional hazard model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) of mortality associated with DII and PA.

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Limited information is available on the links between heavy metals' exposure and coronary heart disease (CHD). We aim to establish an efficient and explainable machine learning (ML) model that associates heavy metals' exposure with CHD identification. Our datasets for investigating the associations between heavy metals and CHD were sourced from the US National Health and Nutrition Examination Survey (US NHANES, 2003-2018).

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Although the association of dietary inflammatory potential, evaluated by the dietary inflammatory index (DII), with all-cause and cause-specific mortality has been reported, evidence remains equivocal, with no relevant dose-response meta-analysis having been conducted. To examine the dose-response association of dietary inflammatory potential with risk of all-cause, cancer, and cardiovascular disease (CVD) mortality, PubMed, Embase, and Web of Science were systematically searched up to August 9, 2021. Cohort studies were included if DII was reported as ≥3 levels or per incremental increase, and if the associations of DII with all-cause, cancer, and CVD mortality were assessed.

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