A mosquito proboscis-inspired cambered microneedle patch for ophthalmic regional anaesthesia.

Introduction: One of the methods for pain management involves the use of local anesthesia, which numbs sensations in specific body regions while maintaining consciousness.

Objectives: Considering the certain limitations (e.g.

Discovery of novel positive allosteric modulators targeting GluN1/2A NMDARs as anti-stroke therapeutic agents.

Excitotoxicity due to excessive activation of NMDARs is one of the main mechanisms of neuronal death during ischemic stroke. Previous studies have suggested that activation of either synaptic or extrasynaptic GluN2B-containing NMDARs results in neuronal damage, whereas activation of GluN2A-containing NMDARs promotes neuronal survival against ischemic insults. This study applied a systematic , , and approach to the discovery of novel and potential GluN1/2A NMDAR positive allosteric modulators (PAMs).

Change in groundwater table depth caused by natural change and human activities during the past 40 years in the Shiyang River Basin, northwest China.

Groundwater is the primary water source for agriculture, social economy, and ecosystem in the Shiyang River Basin (SRB), northwest China. Research on its variation and attribution is of great importance for the sustainable development of local economy, water resources, and the environment. In this study, the changes in the groundwater table depth (GTD) during 1980-2017 in different sub-basins and different periods were analyzed using the linear trend and moving t-test methods.

Effect of Serum Bilirubin Levels on Contrast-induced Acute Kidney Injury: A Systematic Evaluation and Meta-analysis.

Contrast-induced acute kidney injury (CI-AKI) is an important complication following the use of iodinated contrast media. Bilirubin has a protective effect but may also aggravate CI-AKI. The purpose of this systematic review was to assess whether bilirubin is a risk factor for CI-AKI.

Perioperative management and drug selection for sedated/anesthetized patients undergoing MRI examination: A review.

In recent years, magnetic resonance imaging (MRI) technology has become an indispensable imaging tool owing to significant improvements in MRI that have opened up new diagnostic perspectives. Due to the closed environment, long imaging time, and need to remain still during the examination process, the examiner may cannot cooperate with the completion of the examination of the procedure, which increases the need for deep sedation or anesthesia. Achieving this can sometimes be challenging, especially in the special nontraditional environment of MRI equipment (unfamiliar and narrow spaces, away from patients, strong magnetic fields) and in special populations requiring sedation/anesthesia during examinations, which pose certain challenges for the perioperative anesthesia management of MRI.

Design and synthesis of novel GluN2A NMDAR positive allosteric modulators via scaffold hopping strategy as anti-stroke therapeutic agents.

NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo . Activation of NR2A-containing NMDA receptors promotes neuronal survival and exerts a neuroprotective action, whereas over activating GluN2B-containing receptor results in excitotoxicity, increasing neuronal apoptosis. Our previous study has identified Npam 43 as a NMDAR positive allosteric modulators.

[Relationship between urban green-land landscape patterns and air pollution in the central district of Yichang city].

In this paper, four types of landscape structures and their green-land landscape patterns, including the landscapes of dominant green-land patch pattern, even green-land patch pattern, dominant wooded corridor pattern and building or concrete covering pattern (control) in the central district of Yichang city in Hubei Province, were analyzed respectively on the basis of landscape ecological theory. The atmospheric noise and the contents of SO2, NOx and total suspension particle (TSP) of the landscapes were monitored respectively by comparative method. The results showed that the landscape of building or concrete covering pattern (control) was mostly composed of woodless corridors and building or concrete covering patches with the tiptop green-land fragmentation index (18.

[Synthetic evaluation on stand quality of protection forests in the Three Gorges Reservoir Region in western Hubei Province].

Stand qualities of 19 kinds of protection forests in the Three Gorges Reservoir Region in Western Hubei Province were evaluated synthetically by using 12 indexes, and could be classified into four different grades. The relationships between stand quality and some major factors such as crown density, elevation, and origin were also discussed in this paper. The results showed that elevation was a very important factor that influenced the stand quality, and the stand quality of natural forest was higher than other forests.