PRMT5/WDR77 Enhances the Proliferation of Squamous Cell Carcinoma via the ΔNp63α-p21 Axis.

Protein arginine methyltransferase 5 (PRMT5) is a critical oncogenic factor in various cancers, and its inhibition has shown promise in suppressing tumor growth. However, the role of PRMT5 in squamous cell carcinoma (SCC) remains largely unexplored. In this study, we analyzed SCC patient data from The Cancer Genome Atlas (TCGA) and the Cancer Dependency Map (DepMap) to investigate the relationship between PRMT5 and SCC proliferation.

Amorphous germanium encapsulated in flexible nitrogen-doped carbon nanofiber for sodium storage with ultra-long cycling stability.

Germanium (Ge), as a viable candidate anode material for future sodium-ion batteries, has attracted much attention. However, such material is usually troubled by huge volume changes during charge/discharge process, leading to the rapid degradation of electrochemical performance. Notably, construction of carbon coating layers is a practical strategy to alleviate the volumetric effect of Ge.

Plasma-assisted synthesis of ultra-fine NiCoO/NiCo-layered double hydroxides nanoparticles-decorated electrospun carbon nanofibers with enhanced electrochemical performance.

Nickel cobaltate/NiCo-layered double hydroxides (NiCoO/NiCo-LDH) as energy storage materials offer considerable potential for various applications. However, many of current methods for synthesizing NiCoO/NiCo-LDH suffer from long synthesis times, complex preparation process, and high temperatures and high pressures. In this study, we present a green, simple, and efficient approach known as assisted liquid-phase plasma electrolysis, which realizes the rapid fabrication of ultra-fine NiCoO/NiCo-LDH nanoparticle-decorated electrospun carbon nanofibers (NiCoO/NiCo-LDH/CNFs) composites.

Restricted and epitaxial growth of MnO nano-flowers in/out carbon nanofibers for long-term cycling stability supercapacitor electrodes.

Carbon nanofibers (CFs) have been widely applied as electrodes for energy storage devices owing to the features of increased contact area between electrodes and electrolyte, and shortened transmission route of electrons. However, the poor electrochemical activity and severe waste of space hinder their further application as supercapacitors electrodes. In this work, MnO nanoflowers restricted and epitaxial growth in/out carbon nanofibers (MnO/MnO@CF) were prepared as excellent electrode materials for supercapacitors.

Reconstruction method suitable for fast CT imaging.

Reconstructing computed tomography (CT) images from an extremely limited set of projections is crucial in practical applications. As the available projections significantly decrease, traditional reconstruction and model-based iterative reconstruction methods become constrained. This work aims to seek a reconstruction method applicable to fast CT imaging when available projections are highly sparse.

A novel ACE inhibitory peptide from Pelodiscus sinensis Wiegmann meat water-soluble protein hydrolysate.

Pelodiscus sinensis meat is a nutritional food and tonic with angiotensin-converting enzyme (ACE) inhibitory activities. To identify the bioactive substances responsible, several bioinformatics methods were integrated to enable a virtual screening for bioactive peptides in proteins identified within a water-soluble protein fraction of Pelodiscus sinensis meat by Shotgun proteomics. The peptides were generated from the identified proteins by in silico proteolysis using six proteases.

Heterogeneous interfaces in 3D interconnected networks of flower-like 1T/2H Molybdenum disulfide nanosheets and carbon-fibers boosts superior EM wave absorption.

With the wide application of electromagnetic waves in national defense, communication, navigation and home appliances, the electromagnetic pollution problem is becoming more and more prominent. Therefore, high-performance, and low-density composite wave-absorbing materials have attracted much attention. In this paper, three-dimensional (3D) network structures of flower-like 1T/2H Molybdenum disulfide nanosheets anchored to carbon fibers (1T/2H MoS/CNFs) were prepared by electrostatic spinning technique and calcination process.

In Situ Loading of NiZnC Nanoparticles with Carbon Nanotubes to 3D Melamine Sponge Derived Hollow Carbon Skeleton toward Superior Microwave Absorption and Thermal Resistance.

The simple and low-cost construction of a 3D network structure is an ideal way to prepare high-performance electromagnetic wave (EMW) absorption materials. Herein, a series of carbon skeleton/carbon nanotubes/NiZnC composites (CS/CNTs/NiZnC) are successfully prepared by in situ growth of NiZnC and CNTs on 3D melamine sponge carbon. With the increase of precursor, NiZnC nanoparticles nucleate and catalyze the generation of CNTs on the surface of the carbon skeleton.

Co-assisted strategy of sacrificial salt-template and nitrogen-doping to promote lithium storage performance of NiO-Ni/N-C frameworks.

Tailoring the omnidirectional conductivity networks in nickel oxide-based electrodes is important for ensuring their long lifespan, stability, high capacity, and high-rate capability. In this study, nickel metal nanoparticles and a three-dimensional nitrogen-doped carbon matrix were used to embellish the nickel oxide composite NiO-Ni/N-C via simplified hard templating. When a porous nitrogen-doped carbon matrix is present, a rapid pathway would be established for charging and discharging the electrons and lithium ions in a lithium-ion battery, thereby alleviating the volumetric expansion of the NiO nanoparticles during the operation of the battery.

Fabrication of Carboxylate-Functionalized 2D MOF Nanosheet with Caged Cavity for Efficient and Selective Extraction of Uranium from Aqueous Solution.

The efficient removal of radioactive uranium from aqueous solution is of great significance for the safe and sustainable development of nuclear power. An ultrathin 2D metal-organic framework (MOF) nanosheet with cavity structures was elaborately fabricated based on a calix[4]arene ligand. Incorporating the permanent cavity structures on MOF nanosheet can fully utilize its structural characteristics of largely exposed surface area and accessible adsorption sites in pollutant removal, achieving ultrafast adsorption kinetics, and the functionalized cavity structure would endow the MOF nanosheets with the ability to achieve preconcentration and extraction of uranium from aqueous solution, affording ultrahigh removal efficiency even in ultra-low concentrations.

Synthesis of three cisplatin-conjugated asymmetric porphyrin photosensitizers for photodynamic therapy.

Photodynamic therapy provides a promising solution for treating various cancer types. In this study, three distinct asymmetric porphyrin-cisplatin complex photosensitizers (ZnPt-P1, ZnPt-P2, and ZnPt-P3) were synthesized, each having unique side chains. Through a set of experiments involving singlet oxygen detection and density functional theory, ZnPt-P1 was demonstrated to have excellent efficacy, exceeding that of ZnPt-P2 and ZnPt-P3.

Restricted growth of molybdenum carbide nanoparticles in hierarchically porous nitrogen-doped carbon matrix for boosting electromagnetic wave absorption performance.

With the development of electronic science and technology, electromagnetic pollution is becoming increasingly serious, which urgent people to develop wave-absorbing materials with the features of "thin, light, strong and wide". In this paper, restricted growth of molybdenum carbide nanoparticles in hierarchically porous nitrogen-doped carbon matrix (MoC/NC) was designed and prepared via a salt-assisted template route and carbonization process, whose morphology and the wave-absorbing properties are regulated by changing the content of MoC/NC nanoparticles. The honeycomb porous MoC/NC composites with large specific surface area and smooth surface can optimize the impedance matching and allow the entrance, multiple reflections and scattering of incident electromagnetic waves (EMW), which effective enhance the electromagnetic wave consumption.

Synergetic dielectric and magnetic losses of melamine sponge-loaded puffed-rice biomass carbon and NiZnC for optimal effective microwave absorption.

Multi-dimensional design and the combination of multiple phases can effectively enhance the dielectric loss properties and multiple reflection effects of absorbers. Herein, a novel multi-dimensional microporous nanostructured composite, melamine sponge (MS) loaded puffed-rice biomass carbon (C) together with bimetallic carbide material NiZnC (NiZnC-MS/C) was synthesized by simple vacuum filtration and hydrothermal calcination. The result indicates that small NiZnC particles with little Ni doping uniformly decorated on the surfaces of the three-dimensional (3D) melamine sponge and puffed rice carbons.

Investigating Factors Influencing Medical Practitioners' Resistance to and Adoption of Internet Hospitals in China: Mixed Methods Study.

Background: The swift shift toward internet hospitals has relied on the willingness of medical practitioners to embrace new systems and workflows. Low engagement or acceptance by medical practitioners leads to difficulties in patient access. However, few investigations have focused on barriers and facilitators of adoption of internet hospitals from the perspective of medical practitioners.

Genomic Characterization of a Halovirus Representing a Novel Siphoviral Cluster.

Salt mines are a special type of hypersaline environment. Current research mainly focuses on prokaryotes, and the understanding of viruses in salt mines remains limited. Understanding viruses in hypersaline environments is of great significance for revealing the formation and maintenance of microbial communities, energy flow and element cycling, and host ecological functions.

Design of High-Capacity MoS Decorated Nitrogen Doped Carbon Coated Cu S Electrode Structures with Dual Heterogenous Interfaces for Outstanding Sodium-Ion Storage.

The hierarchical Cu S@NC@MoS heterostructures have been firstly constructed by the high-capacity MoS and high-conductive N-doped carbon to co-decorate the Cu S hollow nanospheres. During the heterostructure, the middle N-doped carbon layer as the linker facilitates the uniform deposition of MoS and enhances the structural stability and electronic conductivity. The popular hollow/porous structures largely restrain the big volume changes of active materials.

Phase Transformation and Performance of Mg-Based Hydrogen Storage Material by Adding ZnO Nanoparticles.

ZnO nanoparticles in a spherical-like structure were synthesized via filtration and calcination methods, and different amounts of ZnO nanoparticles were added to MgH via ball milling. The SEM images revealed that the size of the composites was about 2 μm. The composites of different states were composed of large particles with small particles covering them.

Thermal stability of NiZnC: As tunable additive for biomass-derived carbon sheet composites with efficient microwave absorption.

With the rapidly development of radar detection technology and the increasingly complex application environment in military field and electromagnetic pollution surrounded by electron devices, increasingly demand is needed for electromagnetic wave absorbent materials with high absorption efficiency and thermal stability. Herein, a novel NiZnC/Ni loaded puffed-rice derived carbon (RNZC) composites are successfully prepared by vacuum filtration of metal-organic frameworks gel precursor together with layered porous-structure carbon and followed by calcination. The NiZnC particles uniformly decorate on the surface and pores of puffed-rice derived carbon.

MDST: multi-domain sparse-view CT reconstruction based on convolution and swin transformer.

Sparse-view computed tomography (SVCT), which can reduce the radiation doses administered to patients and hasten data acquisition, has become an area of particular interest to researchers. Most existing deep learning-based image reconstruction methods are based on convolutional neural networks (CNNs). Due to the locality of convolution and continuous sampling operations, existing approaches cannot fully model global context feature dependencies, which makes the CNN-based approaches less efficient in modeling the computed tomography (CT) images with various structural information.

Investigation of oral health knowledge and attitudes towards oral health education among elementary school teachers in Zunyi.

Objectives: This study aimed to investigate the oral health knowledge of elementary school teachers and assess their attitude towards oral health education in Zunyi.

Methods: A total of 636 teachers from 10 primary schools in Zunyi were selected by stratified sampling, and their general information, oral health care habits, results of oral health knowledge questionnaire, and attitude towards oral health and oral health education were investigated. Data were statistically analyzed using SPSS 21.

BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network.

Inhibition of the tumour suppressive function of p53 (encoded by TP53) is paramount for cancer development in humans. However, p53 remains unmutated in the majority of cases of glioblastoma (GBM)-the most common and deadly adult brain malignancy. Thus, how p53-mediated tumour suppression is countered in TP53 wild-type (TP53) GBM is unknown.

Association between conscientiousness and team emotional intelligence: A moderated mediation model.

To investigate the influence of interpersonal emotion regulation and conscientiousness on team emotional intelligence. A total of 1369 college students were investigated with the conscientiousness subscale of Big Five Personality Questionnaire, Team Emotional Intelligence Scale and Leadership Positive Emotional Operation Questionnaire. Variance analysis, Pearson product difference correlation analysis, multiple regression analysis and path analysis were used.

Integrated analysis identified novel miRNAs and mRNA in endometriosis.

Objectives: Endometriosis is a common gynecological disease that seriously affects women's health and quality of life. However, the pathogenesis of endometriosis remains uncertain. This study aims to find the key microRNAs (miRNAs) and mRNAs and further to elucidate the pathogenesis of endometriosis.

A new antioxidant made from a pterostilbene functionalized graphene nanocomposite as an efficient treatment for dry eye disease.

Dry eye disease is a common condition that affects the eyes. It is caused by problems with the tear film and the tear dynamics. Dry eye can be caused by an increase in the amount of reactive oxygen species (ROS) in the corneal epithelium.

EZH2 regulates a SETDB1/ΔNp63α axis via RUNX3 to drive a cancer stem cell phenotype in squamous cell carcinoma.

Enhancer of zeste homolog 2 (EZH2) and SET domain bifurcated 1 (SETDB1, also known as ESET) are oncogenic methyltransferases implicated in a number of human cancers. These enzymes typically function as epigenetic repressors of target genes by methylating histone H3 K27 and H3-K9 residues, respectively. Here, we show that EZH2 and SETDB1 are essential to proliferation in 3 SCC cell lines, HSC-5, FaDu, and Cal33.