Publications by authors named "Xueqin Liu"
Background: Exosomes are released by most cell types, including tumor-associated macrophages (TAMs), transfer diverse macromolecules and participate in intercellular communication in cancer. However, whether M2-polarized TAMs (M2-TAMs)-derived exosomes (M2-exos) transmit the oncogenic protein malate dehydrogenase 1 (MDH1) to reprogram lung adenocarcinoma (LUAD) cancer cells is unknown.
Methods: THP-1-differentiated macrophages were co-cultured with A549 cells to generate TAMs (M0-TAMs and M2-TAMs).
Background: Endometrial cancer represents a significant health challenge, with rising incidence and complex prognostic challenges. This study aimed to develop a robust predictive model integrating programmed cell death-related genes and advanced machine learning techniques.
Methods: Utilizing transcriptomic data from TCGA-UCEC and GSE119041 datasets, we employed a comprehensive approach involving 117 machine learning algorithms.
Background: Mastitis caused by Staphylococcus aureus (S. aureus) is one of the most intractable problems for the dairy industry, causing significantly reduced milk yields and early slaughter of cows worldwide. MicroRNAs (miRNAs) can post-transcriptionally regulate gene expression and studies in recent years have shown the importance of miRNA-associated gene regulation in S.
View Article and Find Full Text PDFObjectives: To assess the efficacy of escitalopram combined with quetiapine vs quetiapine alone in the treatment of depressive episodes of bipolar disorder (BPD).
Methods: 88 hospitalized patients with a BPD depressive episode were recruited into the study. All patients were randomized to a control group (n = 44) or the intervention group (n = 44).
A modified vertical pressure bandage to prevent pharyngocutaneous fistula after total laryngectomy.
Braz J Otorhinolaryngol
January 2025
Objective: Pharyngocutaneous Fistula (PCF) is one of the most common and challenging postoperative complications after Total Laryngectomy (TLE). This study aimed to evaluate the impact of the modified Vertical Pressure Bandage (VPB) on the occurrence of Pharyngocutaneous Fistula (PCF) after Total Laryngectomy (TLE) for Head and Neck (H&N) cancer.
Methods: This retrospective study included patients with H&N cancer who underwent TLE at our hospital between January 2010 and January 2021.
Yeast shows promise as a delivery system for drugs and vaccines due to its specific targeting and immunogenic properties. The objective of this research is to create novel and effective yeast-based methods for delivering subunit vaccines. Through the modification of yeast expression plasmids and optimization of expression techniques, a new dual-expression system has been developed.
View Article and Find Full Text PDFThis study aims to explore the feasibility of applying the "Three-Low" technique (low injection rate, low iodine contrast volume, low radiation dose) in coronary CT angiography (CCTA). We prospectively collected data from 90 patients who underwent CCTA at our hospital between 2021 and 2024. The patients were randomly assigned to either the experimental group (n = 45) or the control group (n = 45).
View Article and Find Full Text PDFBackground: Intrahepatic cholangiocarcinoma is a malignant tumor that starts from the epithelium of the bile duct and has a poor prognosis. They are characterized by poor response to chemotherapy and lack of effective targeted therapies; thus, therapeutic options are limited.
Case Presentation: A 59-year-old man was admitted to the hospital for a workup of abnormal CA19-9 levels.
Rabies is an acute lethal disease causing by the neurotropic virus rabies virus (RABV). Rabies immune globulin (RIG) as an indispensable component of rabies postexposure prophylaxis (PEP) always faces with great challenges in terms of costs, stability and safety. Our objective is to develop a novel and potential fully human monoclonal antibodies (mAbs) cocktail for the improvement of rabies PEP.
View Article and Find Full Text PDFThe rearing system of livestock plays a vital role in animal production, meat quality, and overall welfare. This study aimed to assess the influence of cage-rearing system and forest-rearing system on the ileum microbiota, metabolome, and ileal mucosa transcriptome in meat rabbits. Moreover, 16S rDNA sequencing revealed significant differences in the ileal microbiome composition: caged rabbits exhibited a higher abundance of the genera uncultured and , whereas the levels of , unclassified , and uncultured were lower compared to rabbits reared in the forest.
View Article and Find Full Text PDFMetabolic reprogramming is a common feature in tumor progression and metastasis. Like proteins, lipids can transduce signals through lipid-protein interactions. During tumor initiation and metastasis, dysregulation of the Hippo pathway plays a critical role.
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- The study investigates the effects of melatonin (MEL) on seed hypocotyl germination in peony, focusing on its physiological regulation mechanisms.
- Results showed that 100 and 200 µM MEL concentrations significantly improved the rooting rate by reducing starch levels and enhancing -amylase activity, while a concentration of 400 µM was detrimental.
- Additionally, 100 µM MEL increased the levels of gibberellic acid (GA) and radicle thickness while decreasing abscisic acid (ABA), suggesting a key role of MEL in balancing these hormones to promote germination.
Article Synopsis
- Largemouth bass virus (LMBV) poses a serious threat to largemouth bass, leading to high mortality rates and economic losses.
- This study investigates the use of genetically modified Lactococcus lactis to deliver interferon a3 (IFNa3) orally to enhance the immune response in largemouth bass against LMBV.
- Results showed that fish receiving the recombinant L. lactis achieved a 70% survival rate post-LMBV challenge, significantly higher than control groups, with improved immune responses and lower viral loads.
Article Synopsis
- Drought stress significantly affects plant growth, and plants use various adaptations to survive, including the roles of CIPK proteins in stress response.
- This study identifies AtCIPK20's novel localization to cortical microtubules in Arabidopsis, which helps regulate stomatal closure and reduce water loss during drought.
- The findings suggest that multiple CIPK proteins in various plants share this localization, indicating a broader role in abiotic stress resistance that warrants further exploration.
Fully human monoclonal antibodies against Ebola virus possess complete protection in a hamster model.
Emerg Microbes Infect
December 2024
Article Synopsis
- - Ebola disease, caused by ebolaviruses with high mortality rates, can potentially be treated with monoclonal antibody (mAb) therapies, but emerging virus strains necessitate the development of new antibodies.
- - Researchers isolated 11 fully human mAbs from transgenic mice and categorized them based on their binding activities and neutralization properties, identifying mAbs 7D8, 8G6, and 4C1 as potent candidates against ebolavirus.
- - The study found that mAbs 7D8, 8G6, and 4C1 provided complete protection in a hamster model when given shortly after infection, indicating their potential for therapeutic use and further vaccine development.
Article Synopsis
- - Non-small cell lung cancer (NSCLC) has a high rate of mortality and is influenced by circular RNAs (circRNAs). This study focuses on circ_0028826's role in NSCLC development.
- - Researchers employed various techniques like RT-qPCR and western blotting to explore how circ_0028826 affects cell proliferation, migration, and apoptosis in NSCLC, including in vivo tumor models.
- - Findings show that circ_0028826 promotes NSCLC by increasing IDH2 levels through inhibition of miR-758-3p, suggesting that targeting this mechanism could be a potential treatment strategy for NSCLC.
Background: Spring viremia of carp virus (SVCV) infects a wide range of fish species and causes high mortality rates in aquaculture. This viral infection is characterized by seasonal outbreaks that are temperature-dependent. However, the specific mechanism behind temperature-dependent SVCV infectivity and pathogenicity remains unclear.
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- - The study focused on identifying regulatory genetic variants in Holstein cows during early to mid-lactation, examining how these variants influence gene expression and splicing related to milk production traits.
- - Researchers analyzed whole blood samples from 101 cows, discovering a significant number of expressed genes and intron clusters, with specific SNP-gene expression pairs that could affect traits like milk and fat yield.
- - A notable finding was the identification of a key SNP (rs109421300) linked to the DGAT1 gene, which may serve as an important marker for enhancing milk yield and other related traits during lactation.
Article Synopsis
- Senescence is a state of permanent cell growth arrest that can suppress tumors, but senescent cells may also promote cancer progression, especially in hepatocellular carcinoma (HCC).
- Researchers analyzed senescence-related genes (SRGs) in HCC using various computational methods and experimental techniques to better understand their role and improve therapeutic strategies.
- The study identified three distinct patient clusters with different survival rates and immune features, uncovering key genes involved in senescence that could guide treatment options and help address immune suppression in HCC.
Article Synopsis
- * SMSI enables the transfer of electrons from vanadium (V) to the Au NPs, creating electron-rich gold species and establishing strong interactions that help in extracting photogenerated holes and improving charge separation during the reaction.
- * The resulting Au/BVO-SMSI photoanode demonstrates a high photocurrent density (6.25 mA/cm² at 1.23 V), showcasing the potential of SMS
Article Synopsis
- * The study investigates the relationship between chemoresistance in B-ALL and histidine metabolism, revealing that histidine supplementation can improve responsiveness to the standard chemotherapy drug, 6-mercaptopurine (6-MP).
- * It highlights the importance of desuccinylation by the enzyme SIRT5 as a crucial factor in enhancing the effectiveness of histidine therapy, offering a new strategy to combat chemoresistance and improve survival rates in young B-ALL patients.
Article Synopsis
- The study highlights the poor effectiveness of oral rehydration salts (ORS) for treating postural tachycardia syndrome (POTS) in children, emphasizing the need for personalized treatment approaches.
- A case-control analysis involving 130 patients identified five key predictors of ORS response, such as mean corpuscular hemoglobin concentration and mean arterial pressure in an upright position.
- A nomogram model was created to predict treatment outcomes, demonstrating high accuracy and reliability in both training and validation sets, which could aid in better treatment strategies for affected children.
Article Synopsis
- Cost-effective and efficient catalysts are essential for sustainable energy technologies like fuel cells and batteries, which aim to produce clean energy and combat carbon emissions.* -
- Recent advancements in polymer catalysts, noted for their unique synthesis and properties, have shown significant promise in enhancing electrocatalytic performance across various important reactions.* -
- The review covers the design principles, engineering strategies, and current challenges in polymer catalysts, emphasizing the need for deeper understanding and innovative approaches in their development.*
Article Synopsis
- Chronic pain can lead to both physical pain and depressive emotions, posing a challenge for treatment.
- This study found that betaine, a nutrient supplement, effectively reduced depressive-like behaviors caused by chronic pain in a rat model.
- Betaine works by inhibiting the activation of immune cells in the brain, promoting a shift toward anti-inflammatory responses, and decreasing pro-inflammatory factors, suggesting its potential as a therapeutic option for pain-related depression.