Publications by authors named "Xueqiang Pan"

Article Synopsis
  • The study focused on the population pharmacokinetics (PPK) of tacrolimus in Chinese kids under 4 years old following liver transplants and aimed to create software for personalized dosing.
  • Blood concentration data from 85 pediatric patients was collected and analyzed, leading to the development of an individualized tacrolimus dosing software that also tested its accuracy on additional patients.
  • The findings established a one-compartment model for tacrolimus, identifying key factors influencing drug clearance, and confirmed the software's potential for improving personalized medication dosing in young liver transplant patients.
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Article Synopsis
  • - The study focuses on the role of LINC02532, an RNA molecule, in promoting breast cancer progression, with findings showing its abnormal expression in cancerous tissues compared to normal ones.
  • - Experiments involving cell transfection in MCF-7 breast cancer cells revealed that LINC02532 influences cell proliferation, migration, invasion, and apoptosis, while its depletion negatively impacts these activities.
  • - The research uncovered a mechanistic network where LINC02532 interacts with miR-541-3p and HMGA1, influencing tumor growth, particularly noting that silencing LINC02532 hindered tumor development in mice, suggesting potential clinical treatment strategies for breast cancer.
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We designed this study to investigate the associations between physical activity (PA) and the risk of all-cause mortality in cancer survivors using a nationally representative cohort of US adults. This cohort study included 13 cycles of the National Health Interview Surveys, and by matching participants with the National Death Index (2015), survival status was determined. The main outcome was all-cause mortality during follow-up.

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Wuzhuyu decoction (WZYD) is a classic traditional Chinese medicine (TCM) formula. It has been extensively used for treating migraine for thousands of years in TCM. Four potential active ingredients from WZYD, ginsenoside-Rg1 (Rg1), ginsenoside-Rb1 (Rb1), evodiamine (Ev) and rutaecarpine (Ru), were found to have positive correlations with pharmacodynamic indicators involving mouse migraine in our previous study.

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Wuzhuyu decoction is a traditional Chinese medicine used for the effective treatment of migraines, termed 'Jueyin headache', in China. However, there have been few investigations to clarify the composition of Wuzhuyu decoction for the treatment of migraines. In the present study, 10 types of Wuzhuyu decoction were analyzed by chromatograms.

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Stauntonia obovatifoliola Hayata subsp. intermedia is used in China to treat rheumatic arthralgia, hernia pain, and traumatic pain. An accurate and reliable method based on high-performance liquid chromatography with diode array detection has been developed and validated for the quantitative determination of nine triterpenoid saponins in this herb.

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Wuzhuyu Tang is a classical formula for treating migraine, but its' pharmacological ingredients is unclear yet. Present study employed the everted intestinal sac model to collect the absorption samples of 10 kinds of Wuzhuyu decoction, and then analyzed the contents of 9 ingredients in Wuzhuyu Tang and absorption samples quantitatively or semi-quantitatively by HPLC-DAD method. Reserpine was used to establish the mice model of migraine, and then the contents and activities of 5-hydroxytryptamine, noradrenaline, dopamine, nitric oxide and nitricoxide synthase in brain tissues and serums were determined respectively after oral administration of Wuzhuyu Tang.

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