The impact of frailty on chemotherapy intolerance in patients with cervical cancer: A longitudinal study.

Purpose: To explore the potential effects of frailty on chemotherapy intolerance in patients with cervical cancer.

Methods: A longitudinal study of patients with cervical cancer undergoing postoperative Adjuvant Chemotherapy (ACT) was conducted at a hospital in Northwest China from July 2020 to December 2021. Baseline frailty was assessed using the Tilburg Frailty Indicator.

The Impact of Frailty on the Toxic Reaction of Chemotherapy in Patients With Cervical Cancer: A Longitudinal Study.

Background: Longitudinal research on the impact of frailty on chemotherapy toxicity in patients with cervical cancer is limited.

Objectives: To explore the impact of frailty on chemotherapy toxicity in patients with cervical cancer.

Methods: Two hundred fifty-nine postoperative cervical cancer patients from a hospital located in Northwest China were enrolled between July 2020 and December 2021.

Gut microbiota metabolite tyramine ameliorates high-fat diet-induced insulin resistance via increased Ca signaling.

The gut microbiota and their metabolites are closely linked to obesity-related diseases, such as type 2 diabetes, but their causal relationship and underlying mechanisms remain largely elusive. Here, we found that dysbiosis-induced tyramine (TA) suppresses high-fat diet (HFD)-mediated insulin resistance in both Drosophila and mice. In Drosophila, HFD increases cytosolic Ca signaling in enterocytes, which, in turn, suppresses intestinal lipid levels.

The Patients' Presupposed Distrust to Doctors in China: An Explanatory Sequential Mixed Methods Study.

Purpose: The aim of this study was to investigate the current status of patients' presupposed distrust, and to clarify the causes of high presupposed distrust.

Patients And Methods: An explanatory sequential mixed methods study was conducted using a two-stage design. The first phase was a quantitative cross-sectional survey, a total of 384 patients by convenience sampling completed the survey.

Architectural Design of a Blockchain-Enabled, Federated Learning Platform for Algorithmic Fairness in Predictive Health Care: Design Science Study.

Background: Developing effective and generalizable predictive models is critical for disease prediction and clinical decision-making, often requiring diverse samples to mitigate population bias and address algorithmic fairness. However, a major challenge is to retrieve learning models across multiple institutions without bringing in local biases and inequity, while preserving individual patients' privacy at each site.

Objective: This study aims to understand the issues of bias and fairness in the machine learning process used in the predictive health care domain.

Retraction of: The Significance of Thromboelastogram in Predicting Postpartum Hemorrhage and Guiding Blood Transfusion.

This retracts the article DOI: 10.7754/Clin.Lab.

Research on the Integration of Cultural Tourism Industry Driven by Digital Economy in the Context of COVID-19-Based on the Data of 31 Chinese Provinces.

This article examines the impact of digital economy on the integration of China's cultural tourism industry in the context of COVID-19 by measuring the integration degree of cultural tourism industry as a substitute variable of cultural tourism integration. The empirical study found that the development of digital economy during the COVID-19 pandemic did promote the integration of China's cultural tourism industry, and compared with year 2019, the digital economy has strengthened the integration of cultural tourism industry. During the COVID-19 pandemic, the development of digital economy has promoted the integration of China's cultural tourism industry, and the positive effect of digital economy on the integration of China's cultural tourism industry has gradually strengthened compared to previous ones.

The Significance of Thromboelastogram in Predicting Postpartum Hemorrhage and Guiding Blood Transfusion.

Background: The aim of this study was to probe into the significance of the thromboelastogram (TEG) in predicting postpartum hemorrhage and guiding blood transfusion.

Methods: In total, our work selected 200 cases of postpartum hemorrhage patients admitted to the hospital from April 2017 to November 2020 as the research objects, namely the postpartum hemorrhage group. Another 200 cases without postpartum hemorrhage during hospitalized delivery during the same period were chosen as the no postpartum hemorrhage group.

The Effects of Passenger Risk Perception During the COVID-19 Pandemic on Airline Industry: Evidence From the United States Stock Market.

The COVID-19 pandemic has caused a dramatic reshaping of passenger risk perception for airline industry. The sharp increase in risk aversion by air passenger has caused a disastrous impact on the tourism service industry, particularly airline industry. Although the existing literature has provided a lot of studies on the impact of the pandemic on travel industry, there are very few studies discussing the impact of change in passenger risk perception on the stock market performance of airline industry.

A blockchain empowered and privacy preserving digital contact tracing platform.

The spread of the COVID-19 virus continues to increase fatality rates and exhaust the capacity of healthcare providers. Efforts to prevent transmission of the virus among humans remains a high priority. The current efforts to quarantine involve social distancing, monitoring and tracking the infected patients.

Determinants of the Fiscal Support of Governments in Response to the COVID-19 Pandemic.

Fiscal support measures have different implications for public finances in the near term and beyond the COVID-19 pandemic. For this purpose, this paper examines the determinants of governments' fiscal support in response to the COVID-19 pandemic. The empirical analysis is based on the cross-sectional data estimations from 129 developed and developing countries.

The T cell factor, pangolin, from Litopenaeus vannamei play a positive role in the immune responses against white spot syndrome virus infection.

As a downstream interactor of β-catenin, Pangolin which is the homologous protein of the T cell factor/lymphoid enhancer factor (TCF/LEF) in vertebrates is less understood in the research field of immunity. In this study, two isoforms of Litopenaeus vannamei Pangolin (LvPangolin1 and LvPangolin2) were identified. Phylogenetic tree analysis revealed that all of the Pangolin proteins from invertebrates were represented the same lineage.

One-pot synthesis of novel chiral β-amino acid derivatives by enantioselective Mannich reactions catalyzed by squaramide cinchona alkaloids.

An efficient one-pot synthesis of novel β-amino acid derivatives containing a thiadiazole moiety was developed using a chiral squaramide cinchona alkaloid as organocatalyst. The reactions afforded chiral β-amino acid derivatives in moderate yields and with moderate to excellent enantioselectivities. The present study demonstrated for the first time the use of a Mannich reaction catalyzed by a chiral bifunctional organocatalyst for the one-pot synthesis of novel β-amino acid derivatives bearing a 1,3,4-thiadiazole moiety on nitrogen.