Silver Nano-Inks Synthesized with Biobased Polymers for High-Resolution Electrohydrodynamic Printing Toward In-Space Manufacturing.

Electrohydrodynamic (EHD) printing is an additive manufacturing technique capable of producing micro/nanoscale features by precisely jetting ink under an electric field. However, as a new technique compared to more conventional methods, commercially available inks designed and optimized for EHD are currently very limited. To address this challenge, a new silver nanoink platform was developed by synthesizing silver nanoparticles with biobased polymer 2-hydroxyethyl cellulose (HEC).

Risk Assessment of Passenger Behaviors That Influence Accident Type and Severity in Metro Operation.

Background: The unsafe behavior of passengers frequently causes metro operation accidents. This research aims to establish a model for evaluating the risk of unsafe behavior among subway passengers and for assessing the severity of different types of accidents caused by passenger unsafe behavior.

Methods: A risk assessment model that combines the Interaction Matrix (IM) model with a Monte Carlo algorithm was established to quantitatively test the risk of unsafe behavior among passengers.

Machine Learning Models Using SHapley Additive exPlanation for Fire Risk Assessment Mode and Effects Analysis of Stadiums.

Machine learning methods can establish complex nonlinear relationships between input and response variables for stadium fire risk assessment. However, the output of machine learning models is considered very difficult due to their complex "black box" structure, which hinders their application in stadium fire risk assessment. The SHapley Additive exPlanations (SHAP) method makes a local approximation to the predictions of any regression or classification model so as to be faithful and interpretable, and assigns significant values (SHAP value) to each input variable for a given prediction.

Effects of Lyophilization on the Release Profiles of 3D Printed Delivery Systems Fabricated with Carboxymethyl Cellulose Hydrogel.

Recently, increasing numbers of researchers are becoming interested in 3D bioprinting because it provides customizability and structural complexity, which is difficult for traditional subtractive manufacturing to achieve. One of the most critical factors in bioprinting is the material. Depending on the bio-applications, materials should be bio-inert or bio-active, non-toxic, and along with those characteristics, mechanical properties should also meet the applicational or manufacturing requirement.

3D printing of extended-release tablets of theophylline using hydroxypropyl methylcellulose (HPMC) hydrogels.

An extrusion based 3D printer was used to prepare the semi-solid tablets with different drug loading dosages (75, 100, 125 mg) under ambient temperature. The active pharmaceutical ingredient, theophylline, was uploaded within the hydrogels prepared of hydroxypropyl methylcellulose (HPMC) K4M or E4M. The HPMC concentrations were adjusted to different levels (10 and 12% w/w) to fulfill the requirements for 3D printing.

Comprehensive analysis of the GATA transcription factor gene family in breast carcinoma using gene microarrays, online databases and integrated bioinformatics.

Integrated studies of accumulated data can be performed to obtain more reliable information and more feasible measures for investigating the potential diagnostic and prognostic biomarkers of breast cancer and exploring related molecular mechanisms. Our study aimed to explore the GATA family members involved in breast cancer by integrating data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and other online databases. We performed an integrated analysis of published studies from GEO and analyzed clinical data from TCGA and GTEx to evaluate the clinical significance and prognosis values of the GATA family in breast cancer.