Publications by authors named "Xueou Liu"
Article Synopsis
- The study focuses on a common fusion gene in childhood acute lymphoblastic leukemia (ALL) which is generally linked to better outcomes, but about 10% of affected children still experience early relapses with poor survival rates.
- Researchers analyzed data from 87 low-risk B-cell ALL children to identify factors predicting early relapse, highlighting that high gene expression at diagnosis is a key independent predictor.
- Validation studies reinforced that high expression at diagnosis not only correlates with increased relapse risk in low-risk fusion gene-positive children but also in low-risk fusion gene-negative children, suggesting a broader implication for treatment strategies.
The algorithm for cord blood (CB) unit selection is still somewhat ambiguous. We retrospectively analyzed 620 cases of acute leukemia between 2015 and 2020, who were treated with myeloablative single-unit umbilical CB transplantation (UCBT). We found that, when human leukocyte antigen (HLA) mismatch was ≤3/10, CD34 cell dosage <0.
View Article and Find Full Text PDFUnlabelled: Although the concept of "myeloid neoplasm continuum" has long been proposed, few comparative genomics studies directly tested this hypothesis. Here we report a multi-modal data analysis of 730 consecutive newly diagnosed patients with primary myeloid neoplasm, along with 462 lymphoid neoplasm cases serving as the outgroup. Our study identified a "Pan-Myeloid Axis" along which patients, genes, and phenotypic features were all aligned in sequential order.
View Article and Find Full Text PDFArticle Synopsis
- - The study examines how to evaluate immune recovery after hematopoietic stem cell transplantation (HSCT), analyzing immune profiles from over 11,000 post-transplant patients, mostly undergoing allogeneic HSCT.
- - Researchers identified a composite immune signature from various blood cell counts taken 91-180 days post-transplant and created a Composite Immune Risk Score to predict early mortality, showing that high scores correlate with significantly increased risk.
- - Validation of this scoring system revealed it is a reliable, easy-to-use tool that can help identify patients at high risk for complications, allowing for better-targeted care in preventing infections post-transplant.
Article Synopsis
- The study examines how Tianjin, a major Chinese city, responded to its first omicron wave from January to March 2022, focusing on the dynamics of virus clearance among the population.
- In total, 417 cases were analyzed, finding that a significant portion (64%) showed no or mild symptoms, and the median time for viral clearance was 10 days.
- The results suggest that an early implementation of the 'dynamic zero-COVID' policy was effective in controlling the outbreak, and certain clinical features could help predict the duration of isolation for infected individuals.*
Forecasting of severe acute graft-versus-host disease (aGVHD) after transplantation is a challenging 'large p, small n' problem that suffers from nonuniform data sampling. We propose a dynamic probabilistic algorithm, daGOAT, that accommodates sampling heterogeneity, integrates multidimensional clinical data and continuously updates the daily risk score for severe aGVHD onset within a two-week moving window. In the studied cohorts, the cross-validated area under the receiver operator characteristic curve (AUROC) of daGOAT rose steadily after transplantation and peaked at ≥0.
View Article and Find Full Text PDFMinimal residual disease (MRD) levels monitored by polymerase chain reaction are associated with outcomes in acute myeloid leukemia with RUNX1-RUNX1T1. The objectives of our study were to quantitatively compare the predictive value of MRD reduction and absolute copies and assess the influence of other prognostic factors on MRD. A total of 224 consecutive patients with RUNX1-RUNX1T1 aged ≤55 years were included in the MRD study.
View Article and Find Full Text PDFDetection rate is not higher for women with BBD history in breast cancer screening.
J Public Health (Oxf)
June 2021
Article Synopsis
- A study analyzed the breast cancer detection rates among women with a history of benign breast disease (BBD) compared to those without, using data from 33,001 participants in the Multi-modality Independent Screening Trial (MIST) and 6,823 breast cancer patients from the Tianjin Breast Cancer Cases Cohort (TBCCC).
- Findings revealed that the detection rate was slightly lower for women with BBD history (2.83‰) than those without (3.28‰), and they also had a lower occurrence of carcinoma in situ (CIS) in the MIST data.
- Despite having a lower detection rate, women with BBD history were more proactive in undergoing breast examinations, leading to more clinic diagnoses rather
Article Synopsis
- Tacrolimus is a key medication for preventing acute graft-versus-host disease (aGVHD) in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT), and this study investigates its blood concentration correlation with aGVHD incidence in Chinese patients.
- A retrospective analysis of 104 Chinese alloHSCT recipients showed significant variability in tacrolimus blood levels (Cv, C0, C2) during the first 8 weeks post-transplant, with higher concentrations potentially linked to a lower risk of aGVHD, although the trend wasn't statistically significant due to the small sample size.
- The study concludes that monitoring tacrolimus blood levels, particularly at specific time points during treatment, can help predict and
To investigate the association between overall life satisfaction and healthy lifestyle, knowledge of breast cancer, physical examination, and detection rate of breast cancer and benign breast disease in Chinese women. In a multicentered breast disease screening program in China, we enrolled 33,057 women aged 45-65 years without prior diagnosis of breast cancer. After completing an epidemiological questionnaire, all participants were examined by clinical breast examination, breast ultrasound, and mammography independently.
View Article and Find Full Text PDF[Current status of smoking and passive smoking among aged 45 to 65 years old females in five cities of China].
Zhonghua Liu Xing Bing Xue Za Zhi
July 2014
Article Synopsis
- The study aimed to understand smoking and passive smoking trends among Chinese females aged 45-65, utilizing data from a large screening project.
- Only 2.8% of the participants reported a history of smoking, with significant regional differences in prevalence and a notable increase in smoking rates with age.
- While smoking rates were low, there was a high level of passive smoking exposure (45.7%), indicating a critical area for public health strategies.
Previous studies suggested that smoking and passive smoking could increase the risk of breast cancer, but the results were inconsistent, especially for Chinese females. Thus, we systematically searched cohort and case-control studies investigating the associations of active and passive smoking with breast cancer risk among Chinese females in four English databases (PubMed, Embase, ScienceDirect, and Wiley) and three Chinese databases (CNKI, WanFang, and VIP). Fifty-one articles (3 cohort studies and 48 case-control studies) covering 17 provinces of China were finally included in this systematic review.
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- - The study investigates mammographic density (MD) in Chinese women, analyzing its relationship with various risk factors through the Multi-modality Independent Screening Trial (MIST) involving 28,388 asymptomatic women aged 45 to 65.
- - Findings reveal 49.2% had dense breasts, with factors like postmenopausal status and number of live births linked to lower MD, while previous benign breast disease and later age at first birth were tied to higher MD.
- - Compared to American women, younger Chinese women (<50 years) had higher instances of dense breasts, while older women (≥50 years) were more likely to have fatty breasts, suggesting cultural or biological differences in breast density.
Association between dietary factors and breast cancer risk among Chinese females: systematic review and meta-analysis.
Asian Pac J Cancer Prev
November 2014
Background: Evidence for associations between dietary factors and breast cancer risk is inconclusive among Chinese females. To evaluate this question, we conducted a systematic review of relevant case-control and cohort studies.
Methods: Studies were systematically searched among 5 English databases (PudMed, ScienceDirect, Wiley, Clinicaltrials.
Objective: To evaluate associations between tea consumption, alcohol drinking and physical activity and breast cancer risk among Chinese females.
Methods: Three English databases (PubMed, ScienceDirect and Wiley) and three Chinese databases (CNKI, WanFang and VIP) were independently searched by 2 reviewers up to December 2012, complemented by manual searches. The quality of included studies was assessed with the Newcastle-Ottawa Scale items.
Objective: To evaluate the association between induced abortion (IA) and breast cancer risk among Chinese females.
Methods: We searched three English databases (PubMed, ScienceDirect, and Wiley) and three Chinese databases (CNKI, WanFang, and VIP) for studies up to December 2012, supplemented by manual searches. Two reviewers independently conducted the literature searching, study selection, and data extraction and quality assessment of included studies.