Publications by authors named "Xuenan Pi"

Article Synopsis
  • The study explores how epigenetic changes, specifically DNA methylation, might contribute to variations in schizophrenia, particularly focusing on immune-related genes in both never-treated first-episode (FES) and long-term treated (LTS) patients.
  • Research revealed that nearly half of the FES patients showed significant alterations in their methylation patterns linked to immune activity, also confirming similar patterns in the LTS group.
  • The findings suggest a specific subtype of schizophrenia characterized by these immune-related epigenetic changes, indicating potential new treatment avenues aimed at addressing immune dysregulation in these patients.
View Article and Find Full Text PDF

Background: Using epigenetic markers and fragmentomics of cell-free DNA for cancer detection has been proven applicable.

Methods: We further investigated the diagnostic potential of combining two features (epigenetic markers and fragmentomic information) of cell-free DNA for detecting various types of cancers. To do this, we extracted cfDNA fragmentomic features from 191 whole-genome sequencing data and studied them in 396 low-pass 5hmC sequencing data, which included four common cancer types and control samples.

View Article and Find Full Text PDF

Background: Primary Sjogren's syndrome (SS) is a chronic inflammatory disease with unknown aetiology. Although clonal expansion of autoreactive T cells has been identified in patients with SS, the clinical correlation of T-cell receptor (TCR) variance in SS remains unclear.

Methods: TCRβ repertoire sequencing was performed on 260 SS patients with 3-6 months of follow-up in a cohort study to dynamically assess the characteristics of TCR diversity and their clinical significance.

View Article and Find Full Text PDF

Epigenetic modifications are plausible molecular sources of phenotypic heterogeneity across schizophrenia patients. The current study investigated biological heterogeneity in schizophrenia using peripheral epigenetic profiles to delineate illness subtypes independent of their phenomenological manifestations. We applied epigenome-wide profiling with a DNA methylation array from blood samples of 63 schizophrenia patients and 59 healthy controls.

View Article and Find Full Text PDF

Introduction: Gout is a worldwide chronic disease generally caused by high serum levels of uric acid. Using whole exome sequencing, we aimed to explore genetic alterations in hereditary gout.

Patients' Concerns: There were 9 direct descendants diagnosed with gout in total in this family.

View Article and Find Full Text PDF

Increasing resistance to antibiotics has ledthat molecular testing is appropriate as a sub to adoption of seven different bismuth quadruple therapies (BQT) in China without differentiation of first-line or second-line regimens. The objective of this study was to evaluate the efficacy of susceptibility-guided BQT for patients who had experienced previous treatment failures. A total of 133 patients was included and was successfully cultured from 101 patients (75.

View Article and Find Full Text PDF
Article Synopsis
  • The lipopolysaccharide O-antigen structure in European Helicobacter pylori strain G27 includes a trisaccharide, a glucan-heptan, and Lewis antigens essential for immune evasion, but the biosynthetic pathway is not fully understood.
  • Systematic mutagenesis and structural analysis identified key glycosyltransferase genes (HP0102, HP1283, HP1578) involved in synthesizing components of the lipopolysaccharide, with significant variations observed in East-Asian H. pylori strains.
  • The absence of certain genes (HP1283/HP1578) in East-Asian strains raises questions about their role in gastric cancer pathogenesis and suggests a need for further investigation
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionkdqr724i1s4fekfv55klcfon0m5u5hhh): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once