The Function of H2A Histone Variants and Their Roles in Diseases.

Epigenetic regulation, which is characterized by reversible and heritable genetic alterations without changing DNA sequences, has recently been increasingly studied in diseases. Histone variant regulation is an essential component of epigenetic regulation. The substitution of canonical histones by histone variants profoundly alters the local chromatin structure and modulates DNA accessibility to regulatory factors, thereby exerting a pivotal influence on gene regulation and DNA damage repair.

Preparation of ZnNbO anode material for high-performance lithium/sodium-ion batteries.

Niobium-based oxides (M-Nb-O) as promising lithium/sodium-ion storage anode materials have attracted much attention. More types of niobium-based oxides are prepared in order to provide more candidates for anode materials. Herein, ZnNbO as a novel intercalation-type anode material has been reported for the first time.

Mitochondrial K channel-mediated autophagy contributes to angiotensin II-induced vascular dysfunction in mice.

Background And Aim: The present study aimed to investigate whether the mitochondrial K channel contributes to angiotensin II (Ang II)-induced vascular dysfunction, the development of hypertension, and atherosclerosis.

Methods And Results: ApoE (-/-) mice fed a high-fat diet were chronically infused with Ang II for eight weeks and concomitantly treated with losartan (ARB), apocynin, or 5-hydroxy decanoate (5-HD), or 3-methyladenine (3-MA). Systolic blood pressure was measured, and pathological changes of aortic or liver tissue were observed.

A novel APC mutation associated with Gardner syndrome in a Chinese family.

Gardner syndrome (GS) is a specific form of familial adenomatous polyposis (FAP), which manifests as colorectal polyps, multiple osteomas and soft tissue tumors, and in the oral cavity as osteomas of the jaws, odontomas, and abnormal tooth counts. The underlying cause of GS is attributed to mutations in the APC gene. Mutations in this gene disrupt the normal functioning of the protein and lead to the development of GS.

Chemically bonding inorganic fillers with polymer to achieve ultra-stable solid-state sodium batteries.

Inorganic/organic composite solid electrolytes (CSEs) have attracted ever-increasing attentions due to their outstanding mechanical stability and processibility. However, the inferior inorganic/organic interface compatibility limits their ionic conductivity and electrochemical stability, which hinders their application in solid-state batteries. Herein, we report a homogeneously distributed inorganic fillers in polymer by in-situ anchoring SiO particles in polyethylene oxide (PEO) matrix (I-PEO-SiO).

Characterization of a retromolar foramen in a Chinese population: A radiographic study.

Background: Retromolar canal (RMC) arises from the mandibular canal (MC) behind the second or third molar and travels anterosuperiorly to a retromolar foramen (RMF). RMCs and RMFs have generally been ignored in anatomical textbooks and have rarely been reviewed or studied in the anatomical and dental literature until the last decades.

Objective: This study aimed to characterize RMF in a Chinese population concerning its incidence, origin, and classification via anatomical study and periapical radiography.

Co Nanoparticles Embedded in Mesoporous Walls of Carbon Nanoboxes for Rechargeable Zinc-air Batteries.

Design of non-noble metal electrocatalysts with high catalytic activity and stability to replace commercial Pt/C is crucial in the commercialization development of Zn-air batteries (ZABs). In this work, Co catalyst nanoparticles coupled with nitrogen-doped hollow carbon nanoboxes were well designed through zeolite-imidazole framework (ZIF-67) carbonization. As a result, the 3D hollow nanoboxes reduced the charge transport resistance, and the Co nanoparticles loaded on nitrogen-doped carbon supports exhibited excellent electrocatalytic performance for oxygen reduction reaction (ORR, E =0.

In-Plane BO Configuration in P2 Layered Oxide Enables Outstanding Long Cycle Performance for Sodium Ion Batteries.

P2-phase layered cathode materials with distinguished electrochemical performance for sodium-ion batteries have attracted extensive attention, but they face critical challenges of transition metal layer sliding and unfavorable formation of hydration phase upon cycling, thus showing inferior long cycle life. Herein, a new approach is reported to modulate the local structure of P2 material by constructing a state-of-the-art in-plane BO triangle configuration ((Na Ni Co Mn O (BO ) ). Both are unveiled experimentally and theoretically that such a structure can serve as a robust pillar to hold up the entire structure, by inhibiting the H O insertion upon Na (de)intercalation and preventing the structure from deformation, which significantly boost the long cycle capability of P2-materials.

Global regulatory factor AaLaeA upregulates the production of antitumor substances in the endophytic fungus Alternaria alstroemeria.

The global regulatory factor LaeA has been shown to be involved in the biosynthesis of secondary metabolites in various fungi. In a previous work, we isolated an endophytic fungus from Artemisia annua, and its extract had a significant inhibitory effect on the A549 cancer cell line. Phylogenetic analysis further identified the strain as Alternaria alstroemeria.

Global regulatory factor VeA upregulates the production of antitumor substances in endophytic Fusarium solani.

A number of studies have demonstrated that endophytic fungi have the potential to produce antitumor active substances with novel structures and significant activities. In our previous studies, we isolated a Fusarium strain from the stem of the medicinal plant Nothapodytes pittosporoides (Oliv.).

Overexpression of the global regulator FnVeA upregulates antitumor substances in endophytic .

The special niche of endophytic fungi promotes their potential to produce antitumor compounds with novel structure and significant bioactivity for screening of new antitumor drugs. In our previous studies, we isolated a strain from the roots of the medicinal plant and identified it as . We found that the crude extract of had significant antitumor activity on A549 cancer cells, and overexpressing the global regulatory factor FnVeA (the gene of the fungus ) resulted in a significant increase in the antitumor activity, which was approximately fivefold higher than wild strain for relative inhibition rate.

Facile Synthesis of SnNb O @C Composite with Ultrathin Carbon Layer as Anode Materials for High-Performance Sodium-Ion Batteries.

Niobium-based oxides have attracted a lot of attention as anode materials for sodium-ion batteries (SIBs) due to their high theoretical specific capacity, excellent rate capability and exceptional safety. However, their poor intrinsic electronic conductivity and sluggish sodium ions diffusion kinetics severely hinder their practical applicability. Here, SnNb O @C was successfully prepared by a simple solid-state reaction technique coupled with carbon coating.

Targeted Therapeutic Strategies for Triple-Negative Breast Cancer.

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, which is characterized by the absence of estrogen receptor (ER) and progesterone receptor (PR) expression and the absence of human epidermal growth factor receptor 2 (HER2) expression/amplification. Conventional chemotherapy is the mainstay of systemic treatment for TNBC. However, lack of molecular targeted therapies and poor prognosis of TNBC patients have prompted a great effort to discover effective targets for improving the clinical outcomes.

Epitaxial Grown Carbon Nanotubes Reinforced Pyrocarbon Matrix in C/C Composites with Improved Mechanical Properties.

In order to achieve the highly efficient preparation of high-performance carbon/carbon (C/C) composites, epitaxial grown carbon nanotubes (CNTs) and a pyrocarbon matrix were simultaneously synthesized to fabricate CNT-reinforced C/C composites (CC/C composites). With precise control of the temperature gradient, CNTs and the pyrocarbon matrix could grow synchronously within a 2D needle-punched carbon fiber preform. Surprisingly, the CNTs remained intact within the pyrocarbon matrix at the nano-level, and the CNT-reinforced nano-pyrocarbon matrix was compact, with virtually no gaps and pores, which were tightly connected with the carbon fibers without cracks.

All Si N Nanowires Membrane Based High-Performance Flexible Solid-State Asymmetric Supercapacitor.

Recently, much attention has been drawn in the development of flexible energy storage devices due to the increasing demands for flexible/portable electronic devices with high energy density, low weight, and good flexibility. Herein, vertically oriented graphene nanosheets (VGNs) are in situ fabricated on the surface of free-standing and flexible Si N nanowires (NWs) membrane by plasma-enhanced chemical vapor deposition (PECVD), which are directly used as flexible nanoscale conductive substrates. NiCo O hollow nanospheres (HSs) and FeOOH amorphous nanorods (NRs) are finally prepared on Si N @VGNs, which are served as the positive and negative electrodes, respectively.

Hierarchical self-supporting sugar gourd-shape MOF-derived NiCoO hollow nanocages@SiC nanowires for high-performance flexible hybrid supercapacitors.

Rational construction of hierarchical electrode materials has been a research hotspot in the field of energy storage. In this work, metal-organic framework (MOF) derived hollow NiCoO nanocages (NCs) were strung by interwoven SiC nanowires (NWs) network on carbon cloth (CC), forming a unique sugar gourd-like core-shell architecture, which were fabricated via a multi-step process containing of chemical vapor deposition, solution reaction of MOF templates, ion exchanging/etching and subsequent heat treatment. Benefiting from the unique structural advantages, such as hierarchical porous structure with abundant active sites for electrochemical reactions and interwoven conductive networks for electron transport, the formed core-shelled CC/SiC@NiCoO as a binder supercapacitor electrode exhibits excellent electrochemical performance with a large specific capacitance (1377.

Establishment of a Convenient System for the Culture and Study of Perineurium Barrier In Vitro.

The perineurium serves as a selective, metabolically active diffusion barrier in the peripheral nervous system, which is composed of perineurial cells joined together by tight junctions (TJs). Not only are these junctions known to play an essential role in maintaining cellular polarity and tissue integrity, but also limit the paracellular diffusion of certain molecules and ions, whereas loss of TJs barrier function is imperative for tumour growth, invasion and metastasis. Hence, a detailed study on the barrier function of perineurial cells may provide insights into the molecular mechanism of perineural invasion (PNI).

Perineural Invasion in Adenoid Cystic Carcinoma of the Salivary Glands: Where We Are and Where We Need to Go.

Adenoid cystic carcinoma of the salivary gland (SACC) is a rare malignant tumors of the head and neck region, but it is one of the most common malignant tumors that are prone to perineural invasion (PNI) of the head and neck. The prognosis of patients with SACC is strongly associated with the presence of perineural spread (PNS). Although many contributing factors have been reported, the mechanisms underlying the preferential destruction of the blood-nerve barrier (BNB) by tumors and the infiltration of the tumor microenvironment by nerve fibers in SACC, have received little research attention.

Regulatory T-cell expansion in oral and maxillofacial Langerhans cell histiocytosis.

Objective: Langerhans cell histiocytosis (LCH) is a rare myeloid-origin neoplasm characterized by the expansion and dissemination of CD1 a+/CD207+ dendritic cells (LCH cells), but the rarity of its occurrence has long impeded progress in understanding its pathology. We focus on the potentially important role that regulatory T cells (T-reg) play in the oral and maxillofacial LCH tumor microenvironment (TME).

Study Design: Nine cases of oral and maxillofacial LCH, diagnosed from 2009 to 2019, were collected retrospectively from the affiliated hospitals of Southern Medical University.

NiCoO nanosheets sheathed SiC@CNTs core-shell nanowires for high-performance flexible hybrid supercapacitors.

Electrode materials with hierarchical self-supporting core-shell structures, with the metric of structural advantages and synergetic effect for different components, have been widely applied in supercapacitor. Besides, interface designing would improve the bonding of different components and further enhance the stability of electrochemical performance. In this work, by the introduction of CNTs layer to construct the conductive and rugged interface on SiC nanowires (NWs), the formed core-shell SiC@CNTs network were served as conductive skeleton for supporting NiCoO nanosheets (NSs).

Exosomes and other extracellular vesicles in oral and salivary gland cancers.

Extracellular vesicles (EVs, including exosomes) are a group of heterogeneous nanometer-sized vesicles that are released by all types of cells and serve as functional mediators of cell-to-cell communication. This ability is primarily due to their capacity to package and transport various proteins, lipids, and nucleic acids-namely DNA and messenger RNA (mRNA), but also microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). These contents can influence the function and fate of both recipient and donor cells.

Cu nanowires paper interlinked with cobalt oxide films for enhanced sensing and energy storage.

A Cu-NWs paper synthesized by a one-step method is first presented. Owing to its good conductivity, it is an effective framework to interlink TMOs and prevent aggregation. For a practical application, the core-shell Cu NWs@ultrathin CoO delivers good performance for the catalytic oxidation of glucose and energy storage, with a sensitivity of 396.

[Adenoid cystic carcinoma cells produce exosomes that promote tumor cell proliferation].

Objective: To observe the effect of exosomes released by adenoid cystic carcinoma (ACC) cell line SACC-83 on the proliferation of ACC cells.

Methods: Exosomes were isolated from SACC-83 cell culture supernatants using total exosome isolation reagents. The whole-mount exosomes were characterized using transmission electron microscope and Western blotting.

Self-Templating Synthesis of Cobalt Hexacyanoferrate Hollow Structures with Superior Performance for Na-Ion Hybrid Supercapacitors.

Prussian blue (PB) and its analogues (PBA), especially with hollow structures, have attracted growing attention from the researchers of energy storage field. Herein, we have developed a facile self-templating method to synthesize hollow-structured cobalt hexacyanoferrate (CoHCF) with controllable morphologies by using water-soluble precursors as templates. The method is versatile and can be extended to synthesize various PB/PBA hollow structures with tunable composition and morphology.