Publications by authors named "Xuemin Li"
Background: To compare the postoperative visual quality of patients undergoing small-incision lenticule extraction (SMILE) with spherical trial lens intervals of 0.05D and 0.25D in preoperative manifest refraction.
View Article and Find Full Text PDFBackground: As a common complication of Sjogren syndrome (SS), SS-related dry eye disease (SS-DED) significantly affects the patients' quality of life. Pro-inflammatory cytokines in tears are widely believed to play a crucial role in the pathogenesis of SS-DED. A systematic literature review with meta-analyses was conducted to provide a quantitative summary of tear cytokine levels in SS-DED compared with non-SS-DED and healthy controls.
View Article and Find Full Text PDFThelaziasis in an urban woman in Beijing: a case report and literature review.
BMC Ophthalmol
November 2024
Article Synopsis
- Thelaziasis, caused by the parasitic worm Thelazia callipaeda, leads to various eye-related symptoms, potentially resulting in serious conditions like conjunctivitis or blindness, particularly in areas with contact to domestic animals.
- A 41-year-old woman experienced persistent eye discomfort attributed to Thelazia callipaeda, despite initial treatments, but underwent successful removal of the worms from her eye.
- The case emphasizes the need for healthcare professionals to consider parasitic infections in diagnosing eye issues, even in urban settings, and suggests that regional studies on the prevalence of human thelaziasis in China are necessary.
CD161, encoded by the gene, is an inhibitory receptor expresses on various immune cell and has gained attention in immune checkpoint research. In recent studies, has been found to be one of the potential markers of liver diseases such as cirrhosis. Therefore, it will be important to understand what process involved in the liver for the prevention of liver diseases.
View Article and Find Full Text PDFArticle Synopsis
- Enterocytozoon bieneusi is a common zoonotic pathogen found in both humans and animals, posing significant public health risks, with limited data available on its prevalence in farmed minks and raccoon dogs in China.
- A study examined 510 animals, revealing an overall E. bieneusi prevalence of 18.6%, with 10.5% in minks and 28.1% in raccoon dogs, and identified ten different genotypes in these species.
- The detection of several genotypes previously associated with humans in minks and raccoon dogs suggests that these animals could be potential sources of human microsporidiosis, highlighting the need for enhanced monitoring and prevention strategies.
Background: To clarify whether Vitamin D prevent the occurrence of type 2 diabetes mellitus (T2DM) and improve glucose control in T2DM patients, we conducted this umbrella review, taking into account the inconsistent results of existing Meta-analyses. We aim to reveal the causal relationship between Vitamin D and T2DM through summarizing Meta-analyses of observational studies, and clarify the improvement on glucose control in T2DM patients through summarizing Meta-analyses of RCT studies between Vitamin D supplementation and T2DM patients, especially in T2DM patients with Vitamin D deficiency.
Methods: We collected the Meta-analyses of observational studies and RCTs in PubMed, Scopus, Embase, Web of Science, and Cochrane.
Investigating the effects of simulated high altitude on colour discrimination.
BMJ Open Ophthalmol
November 2024
Purpose: To quantify changes in colour vision immediately after exposure to different altitudes of low-pressure hypoxia.
Methods: The study involved 35 healthy participants (ages 20-26). Colour vision was assessed using the Farnsworth-Munsell 100-Hue test at eight different altitudes (condition 1: ground, condition 2: 3500 m, condition 3: 3500 m after 40 min, condition 4: 4000 m, condition 5: 4000 m after 40 min, condition 6: 4500 m, condition 7: 4500 m after 40 min, condition 8: back to the ground).
The Coronavirus disease 2019 (COVID-19) pandemic has led to a global health crisis, including ocular symptoms, primarily targeting the Angiotensin-Converting Enzyme 2 (ACE2) receptor. PM2.5 air pollution may increase infection risk by altering ACE2 expression.
View Article and Find Full Text PDFAirborne viruses are ubiquitous and play critical roles in maintaining ecosystem balance, however, they remain unexplored. Here, it is aimed to demonstrate that highly diverse airborne viromes carry out specific metabolic functions and use different transmission modes under different air quality conditions. A total of 263.
View Article and Find Full Text PDFBackground: The present study aimed to explore the association between the inflammatory potential of diet, assessed by energy-adjusted dietary inflammatory index (E-DII) and reduced rank regression (RRR)-derived inflammatory dietary pattern, and the risk for cognitive impairment (CI) in community-dwelling older adults, especially in older adults with chronic diseases and multimorbidity.
Methods: A total of 549 older adults from Taiyuan city were included in the present cross-sectional study. The Chinese Version of the Mini-Mental State Examination (CMMSE) was used for the evaluation of cognitive function.
Article Synopsis
- Gastrointestinal motility disorders (GMD) are on the rise and often recur, making it important to explore effective treatments like Citri Sarcodactylis Fructus (CSF), a traditional Chinese medicine thought to help with these issues.* -
- This study aimed to assess how CSF extracts promote gastrointestinal motility, identify their active ingredients using various chemical analysis techniques, and validate these findings through models like zebrafish.* -
- The research discovered 42 components in CSF, with 11 potential active ingredients identified, and confirmed six main compounds, including quercetin and kaempferol, as key substances contributing to the improvement of GMD.*
Article Synopsis
- Autoimmune nodopathy (AN) is a rare disease that can occur alongside membranous nephropathy (MN), and it involves the presence of specific antibodies in the serum.
- A study was done on a 65-year-old male with MN who exhibited symptoms like limb numbness and walking instability, revealing positive anti-CNTN1 antibodies, primarily of the IgG4 subtype, and significant nerve damage.
- The comparison of 35 cases of AN with MN to 51 cases of AN without MN found similar clinical characteristics, suggesting that while AN's symptoms may appear with MN, they do not worsen or improve with the presence of MN.
The renin-angiotensin system (RAS) plays an important role in reproductive function. Our previous study identified that angiotensin II type-1 receptor autoantibody (AT1-AA), an autoantibody that activates RAS, was closely associated with infertility. However, its distribution in different types of infertility remained unclear.
View Article and Find Full Text PDFThe toxic effects of polystyrene microplastic/nanoplastic particles on retinal pigment epithelial cells and retinal tissue.
Environ Sci Pollut Res Int
September 2024
Article Synopsis
- The increasing use of contact lenses and other eye-related products has led to greater exposure to microplastics, raising concerns about their impact on eye health, particularly the retina.
- This study tested the effects of microplastics (MPs) and nanoplastics (NPs) on human retinal pigment epithelial cells and found that while MPs didn't significantly affect cell viability, NPs caused notable damage and increased oxidative stress.
- In animal tests, NPs increased inflammatory markers and the presence of inflammatory cells in the retina, highlighting that NPs are more harmful than MPs, given their role in inducing oxidative stress and mitochondrial changes in retinal cells.
Phillyrin is extracted from Forsythia suspensa (Thunb.) Vahl, is significantly higher in (unripe Forsythiae Fructus) Qing qiao than in (ripe Forsythiae Fructus) Lao qiao fruits of the plant. However, the toxicity of phillyrin has not been adequately investigated.
View Article and Find Full Text PDFAim: To investigate the therapeutic effects of hydrogel dressings on neurotrophic keratitis in rats.
Methods: Male Wistar rats, aged 42-56d, were randomly divided into control, experimental, and treatment groups, each consisting of five rats. The experimental and treatment groups underwent neurotrophic keratitis modeling in both eyes.
Objective: To explore whether tea polyphenols(TP) improve sarcopenia in the aged type 2 diabetes(T2DM)model rats via mitochondrial quality control(MQC).
Methods: A total of 55 2-month-old male SD rats were randomly divided into the control group(n=10), the aged model group(aged, n=10) and the aging T2DM model group(n=35). The aging T2DM model group rats were fed with high-sugar and high-fat diet and intraperitoneally injected with 50 mg/kg D-galactose daily.
Suspected cavernous sinus thrombosis and blindness after lumbar spine surgery: A rare case report and literature review.
Int J Surg Case Rep
September 2024
Introduction And Importance: Postoperative visual loss (POVL) is a relatively rare but devastating complication. We reported a case of POVL after spine surgery caused by ischemia of retina and optic nerve, and firstly introduced the possibility of cavernous sinus thrombosis in POVL development.
Case Presentation: A 67-year-old woman diagnosed with "lumbar spinal stenosis" was admitted to undergo posterior lumbar spinal canal decompression surgery because of the persistent lumbago and numbness.
Background: Administration of olanzapine (OLA) is closely associated with obesity and glycolipid abnormalities in patients with schizophrenia (SCZ), although the exact molecular mecha- nisms remain elusive.
Objective: We conducted comprehensive animal and molecular experiments to elucidate the mecha- nisms underlying OLA-induced weight gain.
Methods: We investigated the mechanisms of OLA-induced adipogenesis and lipid storage by em- ploying a real-time ATP production rate assay, glucose uptake test, and reactive oxygen species (ROS) detection in 3T3-L1 cells and AMSCs.
Article Synopsis
- Organohalides are essential in various industries, but directly halogenating certain unreactive organic compounds with standard reagents is often challenging.
- A new catalytic system using thianthrene and trifluoromethanesulfonic acid (TfOH) shows promise in activating regular halogenating reagents for broader applications.
- This approach enables multiple halogenation types across a range of organic compounds by generating a highly reactive electrophilic thianthrenium species during the reaction, facilitating the overall process.
Article Synopsis
- The study aimed to measure changes in dynamic visual acuity (DVA) after acute exposure to low oxygen levels at high altitudes, involving 33 healthy participants aged 20-24.
- Results showed that DVA decreased with increased angular velocity, but initially improved with altitude up to a certain point before declining again.
- The findings suggest that variations in DVA due to altitude and angular velocity can impact pilots' ability to read instruments and make decisions, posing a safety risk during flight.
Article Synopsis
- Salivary duct carcinoma (SDC) is a rare and aggressive cancer, and this case highlights a unique instance where it caused skin metastasis after a burn injury in an 85-year-old man six years post-treatment.
- The patient experienced cutaneous metastasis on his fingertips, leading to concerns about limb function and quality of life, prompting the need for further exploration into the relationship between scalds and distant cancer recurrence.
- The patient underwent targeted radiotherapy which successfully shrank the tumors, with some side effects, reinforcing the idea that radiotherapy is preferable to surgery to preserve finger function in cases of metastatic SDC.
Article Synopsis
- Modified citrus pectin (MCP) is effective in reducing inflammation and protecting cartilage in osteoarthritis (OA) by inhibiting the pro-inflammatory factor Galectin-3 (Gal-3).
- A new hyaluronate (HA) gel-based sustained release system (MCP-HA) was tested on OA rabbit models, showing improvements in symptoms, reduction of cartilage degeneration, and suppression of synovial inflammation.
- Proteomic analysis indicated that MCP-HA not only modulated inflammation but also influenced metabolic pathways, suggesting its potential for long-term treatment of OA.