Effect of task interruption on the situation awareness of air traffic controllers.

Multiple intersecting situational tasks in the field of aviation often cause air traffic controllers to face issues pertaining to interruption and task switching. To investigate the impact of task interruption on the situation awareness of air traffic controllers, two experiments were conducted. Experiment 1, which focused on 44 new graduates preparing to work in the field of air traffic control, revealed that task interruption reduced the participants' levels of situation awareness.

SARS-CoV-2 nucleocapsid protein interaction with YBX1 displays oncolytic properties through PKM mRNA destabilization.

Background: SARS-CoV-2, a highly contagious coronavirus, is responsible for the global pandemic of COVID-19 in 2019. Currently, it remains uncertain whether SARS-CoV-2 possesses oncogenic or oncolytic potential in influencing tumor progression. Therefore, it is important to evaluate the clinical and functional role of SARS-CoV-2 on tumor progression.

MEF2A, a gene associated with mitochondrial biogenesis, promotes drug resistance in gastric cancer.

Chemotherapeutic resistance is a major obstacle to the effectiveness of cisplatin-based chemotherapy for gastric cancer (GC), leading to treatment failure and poor survival rates. However, the underlying mechanisms are not fully understood. Our study demonstrated that the transcription factor myocyte enhancer factor 2A (MEF2A) plays a role in chemotherapeutic drug resistance by regulating the transcription of PGC1α and KEAP1, promoting mitochondrial biogenesis.

The role of inflammasome in chronic viral hepatitis.

Infections of hepatotropic viruses cause a wide array of liver diseases including acute hepatitis, chronic hepatitis and the consequently developed cirrhosis and hepatocellular carcinoma (HCC). Among the five classical hepatotropic viruses, hepatitis B virus (HBV) and hepatitis C virus (HCV) usually infect human persistently and cause chronic hepatitis, leading to major troubles to humanity. Previous studies have revealed that several types of inflammasomes are involved in the infections of HBV and HCV.

Massage ameliorates lumbar disc herniation-related radicular pain in rats by suppressing TLR4/NLRP3 inflammasome signaling transduction.

Background: Lumbar disc herniation (LDH) is a common spinal disease that can cause severe radicular pain. Massage, also known as in Chinese, has been indicated to exert an analgesic effect in patients with LDH. Nonetheless, the mechanism underlying this effect of massage on LDH remains unclarified.

Bioactive polyketides and meroterpenoids from the mangrove-derived fungus TGGP35.

Six new polyketides, which includes three new lactones (talarotones A-C) , one new polyketide (talarotide A) , two new polyenes (talaroyenes A, B) , together with one new meroterpenoid (talaropenoid A) and 13 known compounds were isolated from the mangrove-derived fungus TGGP35. The structure and configuration of the compounds - were elucidated from the data obtained from HR-ESI-MS, IR, 1D/2D NMR spectroscopy, Mo (OAc)-induced electronic circular dichroism (ECD), CD spectroscopy, and modified Mosher's method. Compounds and displayed antioxidant activity with IC values of 0.

Regulation and functions of the NLRP3 inflammasome in RNA virus infection.

Virus infection is one of the greatest threats to human life and health. In response to viral infection, the host's innate immune system triggers an antiviral immune response mostly mediated by inflammatory processes. Among the many pathways involved, the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome has received wide attention in the context of viral infection.

Identification and characterization of the compound heterozygous variants of TYR gene in a northern Chinese family with Oculocutaneous albinism type 1.

Oculocutaneous albinism (OCA) is a genetically heterogeneous disease and is most inherited in an autosomal recessive manner. The characteristic manifestation of OCA is due to disfunction of melanin synthesis. OCA1 is the most severe subtype of OCA and is caused by homozygous or compound heterozygous variants in tyrosinase (TYR) gene, which is the key gene for melanin synthesis.

Modeling Osteoarthritis: MiR-16-5p Attenuates IL-1β Induced Chondrocyte Dysfunction by Targeting MAP2K1 through the MAPK Pathway.

Objective: Osteoarthritis (OA) is a chronic joint disease characterized by cartilage degeneration, significantly reducing the quality of life. Previous report has confirmed that MAP2K1 acts as a potential therapeutic target in OA. Nevertheless, its specific function and related molecular mechanism in OA remain uncharacterized.

Rational design of bimetallic MXene solid solution with High-Performance electrocatalytic N reduction.

Electrocatalytic N reduction reaction (eNRR) was an effective alternative method for green synthesis of NH. By combining the first-principal Density functional theory (DFT) calculations and Monte Carlo (MC) simulation, we systematacially investigated 24 types equal-ratio bimetallic MXene solid solution, involving 88 different catalysts. Our focus was on the catalytic performance of these materials in eNRR.

Bioactive secondary metabolites from tomato-derived bacterium Hnu24.

A series of secondary metabolites have been isolated from the genus of , most of which show antibacterial and insecticidal activities. In order to find more bioactive secondary metabolites from , one new natural component aminoindole dimer baciindole A (), together with seven known compounds () were isolated from the tomato-derived bacterium Hnu24. The structure of compound was elucidated by its HR-ESI-MS spectral data and 1 D/2D NMR spectroscopic analysis.

The effect of SNPs in lncRNA as ceRNA on the risk and prognosis of hepatocellular carcinoma.

Background: Most susceptible loci of hepatocellular carcinoma (HCC) identified by genome-wide association studies (GWAS) are located in non-coding regions, and the mechanism of action remains unclear. The objective of this study was to explore the association of single nucleotide polymorphisms (SNPs) on long non-coding RNAs (lncRNAs) that affect competing endogenous RNAs (ceRNA) regulation mechanism with the risk and prognosis of HCC.

Methods: Based on a set of bioinformatics strategies, eight lncRNA genes that affect HCC through the mechanism of lncRNA-mediated ceRNA were systematically screened, and 15 SNPs that affect microRNA (miRNA) binding in these lncRNA genes were annotated.

Association of Polymorphisms in NHEJ Pathway Genes with HIV-1 Infection and AIDS Progression in a Northern Chinese MSM Population.

Background And Aims: Men who have sex with men (MSM) are at high risk of HIV infection. The nonhomologous end joining (NHEJ) pathway is the main way of double-stranded DNA break (DSB) repair in the higher eukaryotes and can repair the DSB timely at any time in cell cycle. It is also indicated that the NHEJ pathway is associated with HIV-1 infection since the DSB in host genome DNA occurs in the process of HIV-1 integration.

A novel variant of GLI3, p.Asp1514Thrfs*5, is identified in a Chinese family affected by polydactyly.

Background: Polydactyly is a common congenital malformation characterized by the presence of supernumerary fingers or toes. In this case study, we sought to identify the causative pathogenic factor in a family from a northern region of China affected by non-syndromic postaxial polydactyly (PAP).

Methods: After recruiting a three-generation family with PAP, whole-exome sequencing was performed to identify the causative variant.

Association of and Gene Polymorphisms With HIV-1 Infection Susceptibility and AIDS Progression in a Northern Chinese MSM Population.

Some studies have shown that the base excision repair (BER) pathway has an effect on HIV-1 replication. and as key BER genes may affect DNA repair capacity. However, the roles of single nucleotide polymorphisms (SNPs) in and and their impact on HIV-1 infection and AIDS progression remain unclear.

Association Between Nonsyndromic Cleft Lip and Palate and 2 Polymorphic Loci: A Meta-Analysis.

Objectives: The relationship between Noggin ( and methylenetetrahydrofolate reductase and nonsyndromic cleft lip and palate (NSCLP) has been reported participate in craniofacial development but need further evidence. To indicate the susceptibility between the 2 genes and NSCLP, rs227731 and rs1801131 polymorphisms were included in the present research. This research may provide some genetic clues for disease detection and surveillance.

Disease causing property analyzation of variants in 12 Chinese families with polycystic kidney disease.

Background: Polycystic kidney disease (PKD) is an inherited disease that is life-threatening. Multiple cysts are present in the bilateral kidneys of PKD patients. The progressively enlarged cysts cause structural damage and loss of kidney function.

A heterozygous duplication variant of the HOXD13 gene caused synpolydactyly type 1 with variable expressivity in a Chinese family.

Background: Synpolydactyly type 1 (SPD1), also known as syndactyly type II, is an autosomal dominant limb deformity generally results in webbing of 3rd and 4th fingers, duplication of 4th or 5th toes. It is most commonly caused by mutation in HOXD13 gene. In this study, a five-generation Chinese family affected with SPD1 disease were collected.

Pulsed Laser Ablation in Water Synthesis of Black TiO₂-Graphene Oxide Nanocomposites and the Enhanced Photocatalytic Performance.

Black TiO₂-graphene oxide (GO) nanocomposites are synthesized via the pulsed laser ablating TiO₂ powders and GO in deionized water. The simple process enables the preparation of black TiO₂ nanoparticles and anchors them onto the GO sheet in one step. The TiO₂-GO nanocomposites exhibit greatly enhancement for photocatalytic degradation of Rhodamine B (RB) dye in comparison with the pristine and the ablated black TiO₂.

Association between polymorphisms in MRE11 and HIV-1 susceptibility and AIDS progression in a northern Chinese MSM population.

Background: Previous studies reported that DNA damage repair (DDR) genes may play an important role in HIV-1 infection. The MRE11 gene, a member of the MRN complex, plays an essential part in the homologous recombination pathway, which is one of the classical DDR pathways. Previous reports have demonstrated that MRE11 has an effect on HIV-1 replication.

Identification of a pathogenic mutation in a Chinese pedigree with polycystic kidney disease.

Polycystic kidney disease (PKD) is a life‑threatening inherited disease with a morbidity of 1:500‑1,000 worldwide. Numerous progressively enlarging cysts are observed in the bilateral kidneys of patients with PKD, inducing structural damage and loss of kidney function. The present study analyzed one family with PKD.