Modern facial surgical planning and therapeutic strategies rely heavily on the precise segmentation of the nasal cavity and paranasal sinuses from computed tomography (CT) images for quantitative analysis. Nevertheless, manual segmentation is labor-intensive and prone to inconsistencies, highlighting the need for automatic segmentation methods. A significant challenge in this field is the lack of publicly available clinical datasets for research.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
November 2024
Objective: To investigate the relationship of synaptic loss with glucose metabolism and dopaminergic transporters in Parkinson's disease (PD) patients.
Methods: A total of 16 patients with PD and 11 age-matched healthy controls underwent positron emission tomography (PET) with the tracers [F]SynVesT-1, a ligand for the presynaptic terminal marker synaptic vesicle protein 2 A (SV2A), and FDG. PD patients also underwent PET with the dopamine transporter (DAT) ligand [18F]FP-CIT.
Mn-based layered oxide cathodes for sodium-ion batteries with anionic redox reactions hold great potential for energy storage applications due to their ultra-high capacity and cost effectiveness. However, achieving high capacity requires overcoming challenges such as oxygen-redox failure, sluggish kinetics, and structural degradation. Herein, we employ an innovative crystal modulation strategy, using Mn-based NaLiMnO as a representative cathode material, which shows that the highly exposed {010} active facets enable an enhanced rate capability (119.
View Article and Find Full Text PDFIn this study, a mouse model of premature ovarian failure(POF) was constructed by injecting D-galactose(200 mg·kg~(-1)) into the back of the neck for 6 weeks. The mice were randomly divided into a normal group(group N), a model group(group M), and a Qiwei Guibao Granules group(group A, 12.87 g·kg~(-1)).
View Article and Find Full Text PDFThe microencapsulation of polysaturated fatty acids by spray drying remains a challenge due to their susceptibility to oxidation. In this work, antioxidant Pickering emulsions were attempted as feeds to produce oxidation stable tuna oil microcapsules. The results indicated that the association between chitosan (CS) and ovalbumin (OVA) was a feasible way to fabricate antioxidant and wettable complexes and a high CS percentage favored these properties.
View Article and Find Full Text PDFObjectives: The altered neuromelanin in substantia nigra pars compacta (SNpc) is a valuable biomarker in the detection of early-stage Parkinson's disease (EPD). Diagnosis via visual inspection or single radiomics based method is challenging. Thus, we proposed a novel hybrid model that integrates radiomics and deep learning methodologies to automatically detect EPD based on neuromelanin-sensitive MRI, namely short-echo-time Magnitude (setMag) reconstructed from quantitative susceptibility mapping (QSM).
View Article and Find Full Text PDFPowdery mildew disease (PMD) is caused by the obligate biotrophic fungus Cooke & Peck () and results in significant yield losses in soybean ( (L.) Merr.) crops.
View Article and Find Full Text PDFIn this study, magnetic DTPA-modified chitosan composite microspheres (MDCM) were prepared by reverse emulsion-double crosslinking method (carbodiimide followed by glutaraldehyde) for removal of Pb(II) from aqueous solution. The obtained magnetic adsorbents were characterized by FTIR, SEM, XRD, VSM, BET, and C NMR. The effects of the pH, contact time, initial concentration, and competitive metal cations (Na(I), Ca(II), or Mg(II)) on Pb(II) adsorption were investigated.
View Article and Find Full Text PDFPolysaccharides from Pumpkin (Cucurbita moschata Duchesne) (PPs) have many pharmacological activities, including anti-oxidant, immune, and intestinal microbiota regulation. These activities have provided some reminders of its potential therapeutic effect on ulcerative colitis (UC), but this has not yet been confirmed. This study preliminarily confirmed its significant anti-UC activity superior to Salicylazosulfapyridine.
View Article and Find Full Text PDFThis research aims to conduct a comprehensive investigation and analysis of the effects of particle size and concentration on crucial explosion parameters in -decane aerosols. Two sets of -decane aerosols with different concentrations were initially measured, with Sauter mean diameters of 22 and 38 μm, respectively. These measurements served as the foundation for understanding the impact of the particle size on explosion parameters.
View Article and Find Full Text PDFIn this work, the Mn, Co, Ce co-doped corn cob biochar (MCCBC) as catalytic particle electrodes in a three-dimensional heterogeneous electro-Fenton-like (3D-HEFL) system for the efficient degradation of coking wastewater was investigated. Various characterization methods such as SEM, EDS, XRD, XPS and electrochemical analysis were employed for the prepared materials. The results showed that the MCCBC particle electrodes had excellent electrochemical degradation performances of COD in coking wastewater, and the COD removal and degradation rates of the 3D/HEFL system were 85.
View Article and Find Full Text PDFBackground: There is great interindividual difference in the plasma concentration of quetiapine, and optimizing quetiapine therapy to achieve a balance between efficacy and safety is still a challenge. In our study, a population pharmacokinetic (PPK) model considering genetic information was developed with the expectation of comprehensively explaining this observation in Chinese patients with bipolar disorder.
Methods: Patients who were dispensed quetiapine and underwent the therapeutic drug monitoring (TDM) were included.
The effect of obesity on wound-related outcomes in post-ovarian cancer patients is not clear. A number of studies on the association of fat with post-operation injury in ovarian carcinoma have produced contradictory findings. This study aims to conduct a study of the available data to assess the association of obese individuals with significant surgery results in ovarian cancer.
View Article and Find Full Text PDFPhosphatidylglycerol (PG) is a mitochondrial phospholipid required for mitochondrial cristae structure and cardiolipin synthesis. PG must be remodeled to its mature form at the endoplasmic reticulum (ER) after mitochondrial biosynthesis to achieve its biological functions. Defective PG remodeling causes MEGDEL (non-alcohol fatty liver disease and 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like) syndrome through poorly defined mechanisms.
View Article and Find Full Text PDFBackground: Coupling between neuronal activity and blood perfusion is termed neurovascular coupling (NVC), and it provides a potentially new mechanistic perspective into understanding numerous brain diseases. Although abnormal brain activity and blood supply have been separately reported in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), whether anomalous NVC would be present is unclear.
Purpose: To investigate NVC changes and potential neural basis in MELAS by combining resting-state functional MRI (rs-fMRI) and arterial spin labeling (ASL).
Mitochondrial hypochlorite (ClO) plays important and often contradictory roles in maintaining the redox balance of mitochondria. Abnormal ClO levels can induce mitochondrial inactivation and further cause cell apoptosis. Herein, we have developed an anthracene carboxyimide-based fluorescent probe for imaging mitochondrial ClO in living cells.
View Article and Find Full Text PDFJ Tradit Chin Med
June 2023
Premature ovarian failure (POF) is a female reproductive system disease caused by many factors and systems, which has seriously affected the quality of life of women of childbearing age. Clinically, the disease is difficult to treat while its incidence rate shows an increasing trend. In recent years, natural products used as multi-pathway, multi-target and efficient drugs, have become the focus of many research and clinical studies in China and abroad, and the effect of phytochemicals derived from edible plants and Chinese medicine herbs on POF were investigated in several papers.
View Article and Find Full Text PDFA novel pyridine-modified chitosan (PYCS) adsorbent was prepared in a multistep procedure including the successive grafting of 2-(chloromethyl) pyridine hydrochloride and crosslinking with glutaraldehyde. Then, the as-prepared materials were used as adsorbents for the removal of metal ions from acidic wastewater. Batch adsorption experiments were carried out to study the impact of various factors such as solution pH value, contact time, temperature, and Fe (III) concentration.
View Article and Find Full Text PDFIn this study, a novel composite bead (MPB-ALG) was prepared by encapsulating HO modified peanut shell-derived biochar (MPB) into alginate matrix through a facile method. The structure and properties of prepared materials were characterized using FTIR, BET, SEM, and XPS. Batch adsorption experiments were performed to compare the Cu(II) adsorption performance of MPB, plain alginate beads (ALG), and MPB-ALG.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
March 2023
In this study, the underlying mechanism of Qiwei Guibao Granules(QWGB) in the treatment of premature ovarian fai-lure(POF) was explored by the proteomics technique. Firstly, the POF model was induced in mice by intragastric administration of Tripterygium wilfordii glycosides solution at 50 mg·kg~(-1) for 14 days. Ten days prior to the end of the modeling, the estrous cycle of mice was observed every day to evaluate the success of modeling.
View Article and Find Full Text PDFBackground: Structural-functional connectivity (SC- FC) coupling is related to various cognitive functions and more sensitive for the detection of subtle brain alterations.
Objective: To investigate whether decoupling of SC-FC was detected in mild cognitive impairment (MCI) patients on a modular level, the interaction effect of aging and disease, and its relationship with network efficiency.
Methods: 73 patients with MCI and 65 healthy controls were enrolled who underwent diffusion tensor imaging and resting-state functional MRI to generate structural and functional networks.
A photoactive metal-organic framework (MOF), [K(HO)][Cu(DPNDI)][Cu(DPNDI)(CHCN)(HO)] [Cu(DPNDI)HPWO]·2HO (), was prepared by combining a functional photosensitizer , '-bis(4-pyridylmethyl)naphthalene diimide (DPNDI), copper(I) ions, and an oxidation catalyst [PWO] into a single framework via a hydrothermal process. exhibited a stable structure, strong light absorption capacity, a suitable band gap, and photoelectric properties, which provided favorable conditions for photocatalysis. In the confined space, the well-aligned Cu(I) ions and POM polyanions played a synergetic effect in the electron-transfer process and reactive oxygen species generation.
View Article and Find Full Text PDFObjectives: To evaluate the diagnostic efficacy of a modified thyroid imaging reporting and data system (TI-RADS) in combination with contrast-enhanced ultrasound (CEUS) for differentiating between benign and malignant thyroid nodules and to assess inter-observer concordance between different observers.
Methods: This study included 3353 patients who underwent thyroid ultrasound (US) and CEUS in ten multi-centers between September 2018 and March 2020. Based on a modified TI-RADS classification using the CEUS enhancement pattern of thyroid lesions, ten radiologists analyzed all US and CEUS examinations independently and assigned a TI-RADS category to each thyroid nodule.
Non-small cell lung cancer (NSCLC) is a major global health threat with high incidence and mortality. Modulator of apoptosis-1 (MOAP1), also named MAP-1, belongs to the PNMA gene family and plays a key role in regulating apoptosis and tumor growth. However, its influences on NSCLC are largely unclear, and thus were explored in our present study, particularly the underlying mechanisms.
View Article and Find Full Text PDFA redox-active metal-organic framework, , was synthesized by combination of Cu(I), the halogenoid cyanide group (CN), and redox-active organic bridging ligand 2,4,6-tri(4-pyridyl)-1,3,5-triazine (TPT) into one single framework. displays a two-dimensional (2D) plane structure by 1D -Cu(I)-CN- chains connected with TPT ligands. exhibits intrinsic semiconductive features with a moderate bandgap energy (1.
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