A Metabolomics Study of the Effects of Eleutheroside B on Glucose and Lipid Metabolism in a Zebrafish Diabetes Model.

(1) Background: Diabetes is a common metabolic disease that seriously endangers human health. In the present study, we investigated the therapeutic effects of the active ingredient Eleutheroside B (EB) from the traditional Chinese medicine Eleutheroside on diabetes mellitus in a zebrafish model. Concomitant hepatic injury was also analysed, along with the study of possible molecular mechanisms using metabolomics technology.

PluDG: enhancing task-oriented dialogue system with knowledge graph plug-in module.

Task-oriented dialogue systems continue to face significant challenges as they require not only an understanding of dialogue history but also domain-specific knowledge. However, knowledge is often dynamic, making it difficult to effectively integrate into the learning process. Existing large language model approaches primarily treat knowledge bases as textual resources, neglecting to capture the underlying relationships between facts within the knowledge base.

Advances and research needs for disinfection byproducts control strategies in swimming pools.

The control of disinfection byproducts (DBPs) in swimming pools is of great significance due to the non-negligible toxicity and widespread existence of DBPs. However, the management of DBPs remains challenging as the removal and regulation of DBPs is a multifactorial phenomenon in pools. This study summarized recent studies on the removal and regulation of DBPs, and further proposed some research needs.

Removal and transformation of disinfection by-products in water during boiling treatment.

Disinfection by-products (DBPs) remain an ongoing issue because of their widespread occurrence and toxicity. Boiling is the most popular household water treatment method and can effectively remove some DBPs. However, the transformation behavior of DBPs during boiling is still unclear, and the key contributors to toxicity have not been identified.