E2 Ubiquitin-Conjugating Enzymes Regulates Dengue Virus-2 Replication in .

, a major vector of dengue virus (DENV), has a global distribution. Identifying the key components of the ubiquitin system of essential for the replication of viruses could help identify targets for developing broad-spectrum antiviral strategies. This study explores the interaction between E2 ubiquitin-conjugating enzymes (Ubc9) and DENV-2 proteins (NS1, NS5, and E) using cell culture and mosquito models.

Effects of catholyte aging on high-nickel NMC cathodes in sulfide all-solid-state batteries.

Sulfide solid-state electrolytes (SSEs) in all-solid-state batteries (SSBs) are recognized for their high ionic conductivity and inherent safety. The LiNiMnCoO (NMC811) cathode offers a high thermodynamic potential of approximately 3.8 V Li/Li and a theoretical specific capacity of 200 mA h g.

Ruthenium-Catalyzed Synthesis of 2-Pyrazolines via Acceptorless Dehydrogenative Coupling of Allylic Alcohols with Hydrazines.

Described herein is the synthesis of 2-pyrazolines via acceptorless dehydrogenative coupling of allylic alcohols with hydrazines based on a Ru(CO)/NHC-phosphine-phosphine ligand catalytic system. The reaction not only exhibits low catalyst loading (only 0.3 mol %), wide substrate scope, good to excellent yields, and high selectivity but also omits the use of sacrificial hydrogen acceptor with only H and HO as byproducts, making the reaction green and atom-economical.

Capacity recovery by transient voltage pulse in silicon-anode batteries.

In the quest for high-capacity battery electrodes, addressing capacity loss attributed to isolated active materials remains a challenge. We developed an approach to substantially recover the isolated active materials in silicon electrodes and used a voltage pulse to reconnect the isolated lithium-silicon (LiSi) particles back to the conductive network. Using a 5-second pulse, we achieved >30% of capacity recovery in both Li-Si and Si-lithium iron phosphate (Si-LFP) batteries.

Highly selective and additive-free Pd(OAc)/CPP catalyzed hydroaminocarbonylation of alkynes.

Herein, the synthesis of branched α,β-unsaturated amides by a hydroaminocarbonylation reaction of alkynes with various amine substrates such as aromatic amines, aliphatic amines, solid amine sources like NHHCO, and even strongly basic piperidines is reported, using a Pd(OAc)/hybrid N-heterocyclic carbene-phosphine-phosphine (CPP) catalytic system. The reactions feature no additives, wide substrate scope, high selectivity (b/l > 99 : 1) and excellent yields. Mechanistic studies have disclosed that the reaction takes place a palladium hydride pathway.

Unlocking iron metal as a cathode for sustainable Li-ion batteries by an anion solid solution.

Traditional cathode chemistry of Li-ion batteries relies on the transport of Li-ions within the solid structures, with the transition metal ions and anions acting as the static components. Here, we demonstrate that a solid solution of F and PO facilitates the reversible conversion of a fine mixture of iron powder, LiF, and LiPO into iron salts. Notably, in its fully lithiated state, we use commercial iron metal powder in this cathode, departing from electrodes that begin with iron salts, such as FeF.

Organoboron-Promoted Electrochemical Chlorosulfonylation of Alkenes with Sulfonyl Chlorides.

Although extraordinary advances have been achieved by the transition-metal catalysis system, there is an urgent need to explore and develop alternative methodologies that are more environmentally friendly. Herein, we report an electrochemical chlorosulfonylation of alkenes using a wide range of sulfonyl chlorides with an inexpensive, degradable, and commercially available organoboron as a promoter. Furthermore, this protocol employs convergent paired electrolysis, reducing the need for sacrificial anodes and minimizing the extent of hydrogen evolution.

Lithiophilic Hydrogen-Substituted Graphdiyne Aerogels with Ionically Conductive Channels for High-Performance Lithium Metal Batteries.

Lithium (Li) metal stands as a promising anode in advancing high-energy-density batteries. However, intrinsic issues associated with metallic Li, especially the dendritic growth, have hindered its practical application. Herein, we focus on molecular combined structural design to develop dendrite-free anodes.

Wearable intelligent sweat platform for SERS-AI diagnosis of gout.

For the past few years, sweat analysis for health monitoring has attracted increasing attention benefiting from wearable technology. In related research, the sensitive detection of uric acid (UA) in sweat with complex composition based on surface-enhanced Raman spectroscopy (SERS) for the diagnosis of gout is still a significant challenge. Herein, we report a visualized and intelligent wearable sweat platform for SERS detection of UA in sweat.

Solvation-property relationship of lithium-sulphur battery electrolytes.

The Li-S battery is a promising next-generation battery chemistry that offers high energy density and low cost. The Li-S battery has a unique chemistry with intermediate sulphur species readily solvated in electrolytes, and understanding their implications is important from both practical and fundamental perspectives. In this study, we utilise the solvation free energy of electrolytes as a metric to formulate solvation-property relationships in various electrolytes and investigate their impact on the solvated lithium polysulphides.

CO Enrichment Boosts Highly Selective Infrared-Light-Driven CO Conversion to CH by UiO-66/CoS Photocatalyst.

Photocatalytic CO reduction to high-value chemicals is an attractive approach to mitigate climate change, but it remains a great challenge to produce a specific product selectively by IR light. Hence, UiO-66/CoS composite is designed to couple the advantages of metallic photocatalysts and porous CO adsorbers for IR-light-driven CO-to-CH conversion. The metallic nature of CoS endows UiO-66/CoS with exceptional IR light absorption, while UiO-66 dramatically enhances its local CO concentration, revealed by finite-element method simulations.

Correlating chemistry and mass transport in sustainable iron production.

Steelmaking contributes 8% to the total CO emissions globally, primarily due to coal-based iron ore reduction. Clean hydrogen-based ironmaking has variable performance because the dominant gas-solid reduction mechanism is set by the defects and pores inside the mm- to nm-sized oxide particles that change significantly as the reaction progresses. While these governing dynamics are essential to establish continuous flow of iron and its ores through reactors, the direct link between agglomeration and chemistry is still contested due to missing measurements.

Differential effects of parental and developmental temperatures on larval thermal adaptation in oviparous and viviparous model fish species.

Phenotypic plasticity has been identified as a major mechanism of response to changing temperatures. Parental effects are potentially important drivers of ecological and evolutionary dynamics, while developmental plasticity also plays a key role in generating phenotypic variation. However, little is known of the interaction between parental effects and developmental plasticity on the thermal phenotypes of fishes with different reproductive modes (i.

Electrolytes with moderate lithium polysulfide solubility for high-performance long-calendar-life lithium-sulfur batteries.

Lithium-sulfur (Li-S) batteries with high energy density and low cost are promising for next-generation energy storage. However, their cycling stability is plagued by the high solubility of lithium polysulfide (LiPS) intermediates, causing fast capacity decay and severe self-discharge. Exploring electrolytes with low LiPS solubility has shown promising results toward addressing these challenges.

Copper-Mediated and Palladium-Catalyzed Cross-Coupling of Indoles and -Methylpyridinium Salts: A Practical Way to Prepare 3-(Pyridin-2-yl)indoles.

Herein, a Pd/Cu bimetallic-catalyzed direct C-H heteroarylation of pyridines via the traceless protecting group strategy is described. A series of -methyl-activated pyridines and 1-methylindoles are coupled with high regioselectivity to produce the corresponding 3-(pyridin-2-yl)indoles in moderate to good yields, wherein related electron-rich heterocycles (e.g.

Ni Anchored to Hydrogen-Substituted Graphdiyne for Lithium Sulfide Cathodes in Lithium-Sulfur Batteries.

Lithium-sulfur (Li-S) batteries are promising candidates for next-generation energy storage systems due to their high theoretical energy density and the low cost of sulfur. However, slow conversion kinetics between the insulating S and lithium sulfide (LiS) remains as a technical challenge. In this work, we report a catalyst featuring nickel (Ni) single atoms and clusters anchored to a porous hydrogen-substituted graphdiyne support (termed Ni@HGDY), which is incorporated in LiS cathodes.

An Evaluation of Fluorouracil plus Paclitaxel and Oxiliplatin as a First-Line Treatment for Advanced Gastric Squamous Cell Carcinoma.

Objective: To investigate the efficacy of fluorouracil (FU) combined with paclitaxel (PTX) and oxaliplatin (OXA) as the first-line treatment for advanced gastric signet ring cell carcinoma (SRCC) and its influence on human epidermal growth factor receptor 2 (HER-2) expression.

Methods: We collected one hundred and sixty-eight patients with advanced gastric SRCC, including 87 patients treated with FU combined with PTX and OXA as the study group (SG) and 81 patients treated with FU combined with OXA as the control group (CG). We compared indicators such as efficacy and adverse reactions after treatment between the two groups and also detected serum HER-2 expression pre- and post-treatment.

Absorption, metabolism, and functions of hyaluronic acid and its therapeutic prospects in combination with microorganisms: A review.

Hyaluronic acid (HA) is key to the stability of the internal environment of tissues. HA content in tissues gradually decreases with age, causing age-related health problems. Exogenous HA supplements are used to prevent or treat these problems including skin dryness and wrinkles, intestinal imbalance, xerophthalmia, and arthritis after absorption.

Tandem Ring-Contraction/Regioselective C-H Iodination Reaction of Pyridinium Salts.

A facile route for direct access to the 4-iodopyrrole-2-carbaldehydes from pyridinium salts has been successfully developed, which undergoes cascade pyrrole-2-carbaldehydes construction/selective C4 position iodination process. Using NaSO as an oxidant and readily available sodium iodide as an iodine source, a variety of 4-iodopyrrole-2-carbaldehydes were obtained in good to excellent yields. Atom- and step-economy, good functional group tolerance, high regioselectivity, as well as mild conditions entail this transformation an alternative strategy for enriching pyrroles library.

Hydrogen-substituted graphdiyne-assisted ultrafast sparking synthesis of metastable nanomaterials.

Metastable nanomaterials, such as single-atom and high-entropy systems, with exciting physical and chemical properties are increasingly important for next-generation technologies. Here, we developed a hydrogen-substituted graphdiyne-assisted ultrafast sparking synthesis (GAUSS) platform for the preparation of metastable nanomaterials. The GAUSS platform can reach an ultra-high reaction temperature of 3,286 K within 8 ms, a rate exceeding 10 K s.