Immune-Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults.

Unlabelled: Ageing is often accompanied with a decline in immune system function, resulting in immune ageing. Numerous studies have focussed on the changes in different lymphocyte subsets in diseases and immunosenescence. The change in immune phenotype is a key indication of the diseased or healthy status.

Silver nanoparticles deposited carbon microspheres nanozyme with enhanced peroxidase-like catalysis for colorimetric detection of Hg in seafood.

Novel methods for high-performance detection of Hg in seafood are critical for ensuring food safety and human health. Herein, Ag nanoparticles (Ag NPs) were successfully deposited on carbon microspheres (CMs) to form Ag NPs-CMs nanocomplex. The proposed Ag NPs-CMs could oxidize colorless 3,3',5,5'-tetramethylbenzidine (TMB) to blue oxidation state TMB (oxTMB) in the presence of hydrogen peroxide (HO) and had a significant UV-vis absorption peak at 652 nm.

A versatile platform for colorimetric, fluorescence and photothermal multi-mode glyphosate sensing by carbon dots anchoring ferrocene metal-organic framework nanosheet.

Concerns regarding pesticide residues have driven attempts to exploit accurate, prompt and straightforward approaches for food safety pre-warning. Herein, a nanozyme-mediated versatile platform with multiplex signal response (colorimetric, fluorescence and temperature) was proposed for visual, sensitive and portable detection of glyphosate (GLP). The platform was constructed based on a N-CDs/FMOF-Zr nanosensor that prepared by in situ anchoring nitrogen-doped carbon dots onto zirconium-based ferrocene metal-organic framework nanosheets.

Construction of ratiometric fluorescence sensor and test strip with smartphone based on dual-emission carbon dots for the specific detection of chlortetracycline.

Concerns about environmental and food contamination caused by chlortetracycline (CTC) residues have prompted people to explore efficient and convenient CTC monitoring platforms. However, the reported fluorescent probes generally fail to selectively detect CTC due to the structural similarity of tetracycline antibiotics. Herein, an intrinsic dual-emission carbon dots (D-CDs) ratiometric fluorescence sensor was prepared for highly sensitive and selective determination of CTC over other tetracyclines by one-step synthesis.

Carbon dots@Cu metal-organic frameworks hybrids for ratiometric fluorescent determination of pesticide thiophanate-methyl.

A dual-emission fluorescent (FL) probe was constructed by coordinating Cu of copper metal-organic frameworks (Cu-MOFs) with - COO group of carbon dots (CDs) for pesticide thiophanate-methyl (TM) determination. TM was recognized by organic ligands (HBDC and HBDC-NH) of Cu-MOFs via π stacking. Due to the higher affinity of Cu to TM than ligands and CDs, TM chelated with Cu to form TM-Cu complex.

A dual-function chitosan packaging film for simultaneously monitoring and maintaining pork freshness.

Exploring food packaging films simultaneously possess freshness monitoring and maintaining can effectively tackle food safety issues. Here, we constructed a chitosan/N-doped carbon dots (CS/N-CDs) film which can monitor the freshness of pork based on pH-mediated fluorescent sensing and extend the shelf life based on the antioxidant, antibacterial and UV shielding properties. The fluorescent intensity of CS/N-CDs films increased with the increase of pork pH from 5.

UiO-67 decorated on porous carbon derived from Ce-MOF for the enrichment and fluorescence determination of glyphosate.

A nanocomposite was prepared by loading UiO-67 nanoparticles onto porous carbon materials derived from Ce-MOF (Ce-PC) for fluorescence detection of glyphosate. The probe (UiO-67/Ce-PC) exhibits fluorescence emission at 414 nm as the response signal under excitation at 310 nm. The fluorescence enhancement mode of UiO-67 reduces the background interference, and the introduction of Ce-PC provide hierarchical nanostructure and large specific surface area that can increase the contact availability and improve the pre-enrichment effect, ensuring UiO-67/Ce-PC with superior sensitivity.

Ratiometric fluorescent sensing carbendazim in fruits and vegetables via its innate fluorescence coupling with UiO-67.

A ratiometric fluorescent sensor was facilely fabricated using innate fluorescence of carbendazim (MBC) and fluorescent UiO-67 to sensitively and selectively detect MBC in food matrixes. The innate fluorescence of MBC provided a signal at 311 nm (F), and the fluorescent UiO-67 at 408 nm (F) could recognize MBC through π-π stacking inducing fluorescent quenching relied on photoelectron transfer (PET). The ratio (F/F) of the fluorescence enhancement of MBC and the quenching of UiO-67 linearly responded to the MBC concentrations of 0-47.

Carbon dots based ratiometric fluorescent sensing platform for food safety.

Food safety has become a major global concern and the rapid detection of food nutritional ingredients and contaminants has aroused much more attention. Nanomaterials-based fluorescent sensing holds great potential in designing highly sensitive and selective detection strategies for food safety analysis. Carbon dots (CDs) possess tremendous prospects in fluorescent sensing food ingredients and contaminants due to their superior properties of chemical and photostability, highly fluorescence with tunability, and no/low-toxicity.

Heavy metal ions' poisoning behavior-inspired etched UiO-66/CTS aerogel for Pb(II) and Cd(II) removal from aqueous and apple juice.

Here, inspired by the poisoning process of heavy metal in human body that the accidental ingested heavy metal can anchor to the functional groups of DNA/protein/enzyme to exert their toxicities during the rapid blood circulation, we developed the adsorbent that enveloped Etched UiO-66 with abundant functional groups into chitosan (CTS) aerogel to capture Pb(II) and Cd(II) in aqueous and apple juice. SEM, XRD and FTIR spectra were used to characterize the Etched UiO-66/CTS aerogel. The results showed that Etched UiO-66/CTS aerogel has a three-dimensional porous structure, and -OH groups of CTS interact with Zr(IV) of Etched UiO-66 to form the stable UiO-66/CTS aerogel.

Terbium (III)-referenced N-doped carbon dots for ratiometric fluorescent sensing of mercury (II) in seafood.

A ratiometric fluorescence (FL) sensor was fabricated by coordinating 2, 6-pyridinedicarboxylic acid (DPA) sensitized Tb (Tb-DPA) with NH and COOH on the surface of the N-doped carbon dots (N-CDs) for detecting Hg in seafood. The sensor exhibited two FL emissions at 436 nm (N-CDs) as the response signal and at 543 nm (Tb-DPA) as the reference signal when excited at 290 nm. After adding Hg, the FL emission at 436 nm was significantly quenched and the FL emission at 543 nm was negligibly changed.

Cu-Triggered Carbon Dots with Synchronous Response of Dual Emission for Ultrasensitive Ratiometric Fluorescence Determination of Thiophanate-Methyl Residues.

Copper ion (Cu)-triggered carbon dots (CDs/Cu) with dual emissions were utilized to develop a ratiometric fluorescence sensor for ultrasensitive detection of inert thiophanate-methyl (TM). TM could be recognized by CDs/Cu through π-π stacking and could chelate Cu of CDs/Cu through metal ion coordination, inducing synchronous fluoresent quenching of the dual emission of CDs/Cu based on the excited state intramolecular proton transfer and the ligand-to-metal charge transfer. The fluorescence ratio of CDs/Cu (/) linearly responded in a TM concentration of 0.

N,S co-doped carbon dots based fluorescent "on-off-on" sensor for determination of ascorbic acid in common fruits.

A switchable sensor based on N and S co-doped carbon dots (N,S-CDs) was developed to determine ascorbic acid (AA) content in common fruits via fluorescence quenching of N,S-CDs by Fe (off) and recovery by AA (on). TEM showed that the particle size was 2.35-7.

Efficient removal and environmentally benign detoxification of Cr(VI) in aqueous solutions by Zr(IV) cross-linking chitosan magnetic microspheres.

Zirconium(IV) cross-linking chitosan (CTS) magnetic microspheres (FeO@Zr-CTS) as a recoverable adsorbent were synthesized through the coordination reaction between zirconium oxychloride and CTS biopolymeric matrix for efficient adsorption and simultaneous detoxification of hexavalent chromium, Cr(VI), in aqueous solutions. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) confirmed the formation of core@shell magnetite microspheres. X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FT-IR) verified the crosslinking of Zr(IV) to CTS on the microspheres.

Surface molecularly imprinted polymer capped Mn-doped ZnS quantum dots as a phosphorescent nanosensor for detecting patulin in apple juice.

A Mn-doped ZnS quantum dots (QDs) based nanosensor for selective phosphorescent determination of patulin (PAT) was synthesized with 6-hydroxynicotinic acid (6-HNA) as dummy template via a surface molecular imprinting sol-gel process. FTIR and XRD indicated the successful graft of molecularly imprinted polymer (MIP) onto crystal QDs. Binding tests revealed that the MIP-QDs presented higher selectivity, adsorption capacity and mass transfer rate than non-imprinted polymers, demonstrating a specific recognition for PAT among competitive mycotoxins and its analogues with the imprinting factor of 2.