Imaging and Downstaging Bladder Cancer with the Lu-Labeled Bioorthogonal Nanoprobe.

Efforts on bladder cancer treatment have been shifting from extensive surgery to organ preservation in the past decade. To this end, we herein develop a multifunctional nanoagent for bladder cancer downstaging and bladder-preserving therapy by integrating mucosa penetration, reduced off-target effects, and internal irradiation therapy into a nanodrug. Specifically, an iron oxide nanoparticle was used as a carrier that was coated with hyaluronic acid (HA) for facilitating mucosa penetration.

Exploring atherosclerosis imaging with contrast-enhanced MRI using PEGylated ultrasmall iron oxide nanoparticles.

Plaque rupture is a critical concern due to its potential for severe outcomes such as cerebral infarction and myocardial infarction, underscoring the urgency of noninvasive early diagnosis. Magnetic resonance imaging (MRI) has gained prominence in plaque imaging, leveraging its noninvasiveness, high spatial resolution, and lack of ionizing radiation. Ultrasmall iron oxides, when modified with polyethylene glycol, exhibit prolonged blood circulation and passive targeting toward plaque sites, rendering them conducive for MRI.

Reversing Acute Kidney Injury through Coordinated Interplay of Anti-Inflammation and Iron Supplementation.

Acute kidney injury (AKI) induced by ischemia reperfusion is closely related to mitochondrial dysfunction. Nicotinamide adenine dinucleotide (NAD ) can enhance the mitochondrial function and restrain the following inflammation, but it is hardly delivered and lacks renal targeting ability. To address these problems, herein, an ultrasmall Fe O nanoparticle is used as a carrier to deliver nicotinamide mononucleotide (NMN), a precursor of NAD .

Energy investigation of effects of O on mechanical properties of NiAl intermetallics.

We have investigated effects of O on mechanical properties of NiAl by calculating the cleavage energy (γ(C)) and the unstable stacking fault energy (γ(us)) using a first-principles method. O is shown to reduce γ(C)/γ(us) for the [001](110) and [100](001) slip systems, indicating that the presence of O should be associated with the ductility reduction of NiAl. Further, γ(C)/γ(us) of the NiAl-O system can be increased by Cr, suggesting the possibility to suppress the negative effect of O via alloying elements.

Bonding characteristics in NiAl intermetallics with O impurity: a first-principles computational tensile test.

We have performed a first-principles computational tensile test on NiAl intermetallics with O impurity along the [001] crystalline direction on the (110) plane to investigate the tensile strength and the bonding characteristics of the NiAl-O system. We show that the ideal tensile strength is largely reduced due to the presence of O impurity in comparison with pure NiAl. The investigations of the atomic configuration and bond-length evolution show that O prefers to bond with Al, forming an O-Al cluster finally with the break of O-Ni bonds.

Formation of a coplanar O-Al bonding cluster: the effect of O impurity on a Σ = 5 NiAl grain boundary from first-principles.

The site occupancy, structure, and bonding properties of O in an NiAl grain boundary (GB) have been investigated by employing a first-principles total energy method based on density functional theory with the generalized gradient approximation and ultrasoft pseudopotential. The Σ5(310)/[001] tilt GB of NiAl has been chosen because (i) the Σ = 5 GB has been observed to be a higher fraction in NiAl experimentally, and (ii) the Σ5(310)/[001] is energetically favorable in comparison with the Σ5(210)/[001]. The NiAl GB is shown to favor the O segregation with a segregation energy of -1.

Mapping and initial analysis of human subtelomeric sequence assemblies.

Physical mapping data were combined with public draft and finished sequences to derive subtelomeric sequence assemblies for each of the 41 genetically distinct human telomere regions. Sequence gaps that remain on the reference telomeres are generally small,well-defined,and for the most part,restricted to regions directly adjacent to the terminal (TTAGGG)n tract. Of the 20.