Publications by authors named "Xuekui Wang"
Article Synopsis
- - Tinospora sagittata, known for its medicinal properties, has its secondary metabolite production affected by environmental factors, particularly nitrogen levels, necessitating better growth conditions for optimal metabolite synthesis.
- - The study reveals that certain enzymes crucial for secondary metabolite biosynthesis, like berberine bridge enzymes (BBEs), show high expression in low nitrogen conditions, while other enzymes respond differently to varying nitrogen concentrations.
- - Findings indicate that nitrogen fertilization significantly influences specialized metabolism in Tinospora sagittata, with implications for both agricultural practices and the pharmaceutical industry regarding the cultivation of this medicinal plant.
Article Synopsis
- Tinospora sagittata is a medicinal plant in the Menispermaceae family, known for its tuber's use in traditional Chinese medicine, which is high in valuable compounds like diterpenoids and alkaloids.
- Researchers created a detailed, high-quality genome for T. sagittata using advanced sequencing techniques, producing a genome size of 2.33 Gb with 4483 contigs.
- This genome assembly is significant as it's the first of its kind for the Menispermaceae family, contributing to the understanding of the plant's evolution and the biosynthesis of its medicinal compounds.
Article Synopsis
- Wolfiporia cocos is a special mushroom from China that makes a helpful substance called pachymic acid (PA) used in medicine.
- Scientists studied its genes to understand how PA is made, finding key genes connected to its production.
- They discovered that changing the activity of certain genes affects how much PA the mushroom produces, which could help improve its medicinal benefits.
Background: The triglyceride-glucose (TyG) index is a predictor of cardiovascular diseases; however, to what extent the TyG index is associated with cardiovascular diseases through renal function is unclear. This study aimed to evaluate the complex association of the TyG index and renal function with cardiovascular diseases using a cohort design.
Methods: This study included participants from the China Health and Retirement Longitudinal Study (CHARLS) free of cardiovascular diseases at baseline.
(2 = 34), a medicinal and edible plant in the Rosaceae, is commonly used in traditional Chinese medicine. To date, the lack of genomic sequence and genetic studies has impeded efforts to improve its medicinal value. Herein, we report the use of an integrative approach involving PacBio HiFi (third-generation) sequencing and Hi-C scaffolding to assemble a high-quality telomere-to-telomere genome of The genome comprised 650.
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- * Functional peptides that enhance this differentiation face challenges due to low efficiency and rapid degradation, prompting the creation of a specialized peptide with self-assembly capabilities.
- * A newly designed nanofiber hydrogel can be activated by ultrasound, promoting M2 macrophage activity and accelerating bone regeneration by encouraging stem cells to become bone-forming cells.
Article Synopsis
- - Bubble-propelled Janus micromotors are gaining popularity in environmental and medical applications due to their impressive movement capabilities, primarily driven by the growth and collapse of bubbles.
- - This study used a finite element method to understand how bubble evolution affects the motion of these micromotors, confirming the model's validity through the scallop theorem.
- - Findings indicate that while both bubble growth and collapse contribute to micromotor displacement, the displacement from bubble collapse is considerably larger; factors such as bubble size and collapse time were also examined.
Medicinal plants produce important substrates for their adaptation and defenses against environmental factors and, at the same time, are used for traditional medicine and industrial additives. Plants have relatively little in the way of secondary metabolites via biosynthesis. Recently, the whole-genome sequencing of medicinal plants and the identification of secondary metabolite production were revolutionized by the rapid development and cheap cost of sequencing technology.
View Article and Find Full Text PDFPeriodontitis involves chronic inflammation of the tissues around the teeth caused by plaque and the corresponding immune response. Growth arrest-specific protein 6 (GAS6) and AXL receptor tyrosine kinase (AXL) are known to be involved in inflammatory diseases, while signal transducer and activator of transcription-1 (STAT1) and suppressor of cytokine signaling (SOCS) are related to inflammatory processes. Moreover, miRNA34a directly targets to regulate the AXL expression.
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- Chinese goldthread (Coptis chinensis) is an important medicinal plant with a newly assembled high-quality genome that gives insights into its biology.
- The study identifies a historical whole-genome duplication event in the Ranunculaceae family and characterizes key genes related to the production of protoberberine-type alkaloids.
- A specific gene, CYP719, plays a crucial role in synthesizing berberine, which may have implications for the development of other related medicinal compounds.
Hypertension is a cardiovascular disease that causes great harm to health and life, affecting the function of important organs and accompanied by a variety of secondary diseases, which need to be treated with drugs for a long time. alone or combination with western medicine has played an important role in traditional Chinese medicine. Although is used clinically to treat hypertension, its functional molecular mechanism and pharmacological mechanism have not been elucidated.
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- Ethylene and jasmonate are crucial for rice plants to adapt to salt stress, but their interaction in seminal root growth during this stress is not well understood.
- The study found that salt (NaCl) triggers both ethylene and jasmonate biosynthesis, with ethylene promoting jasmonate production, which ultimately hinders root growth.
- Jasmonate reduces root growth by decreasing the number of meristem cells and inhibiting cell elongation through down-regulation of specific growth-related genes.
Article Synopsis
- Fr. Schmidt is a traditional medicinal herb from southwestern China known for treating bruise injuries and rheumatoid arthritis (RA), with its medicinal benefits stemming mainly from triterpenoid saponins extracted from its rhizomes.
- The wild population of the plant has dwindled due to over-exploitation, prompting research into its cultivation and the need to monitor the quality of the herb through gene expression studies.
- This study evaluated the expression of 10 potential reference genes to establish reliable alternatives for RT-qPCR testing, identifying that two genes were consistently stable for analysis across different plant organs and stages, while specific genes were better suited for the rhizomes at the vegetative stage.
Potential Suppressive Effect of Nicotine on the Inflammatory Response in Oral Epithelial Cells: An In Vitro Study.
Int J Environ Res Public Health
January 2021
Smoking is a well-recognized risk factor for oral mucosal and periodontal diseases. Nicotine is an important component of cigarette smoke. This study aims to investigate the impact of nicotine on the viability and inflammatory mediator production of an oral epithelial cell line in the presence of various inflammatory stimuli.
View Article and Find Full Text PDFCorrelation between periodontitis and atherosclerosis is well established, and the inherent mechanisms responsible for this relationship remain unclear. The biological function of growth arrest-specific 6 (gas6) has been discovered in both atherosclerosis and inflammation. Inhibitory effects of gas6 on the expression of inflammatory factors in human umbilical vein endothelial cells (HUVECs) stimulated by Porphyromonas gingivalis lipopolysaccharide (P.
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- Soil types and cropping systems significantly affect the diversity and composition of rhizospheric fungal communities, highlighting the importance of these factors in agricultural practices.
- A study on Franch, a vital medicinal plant in China, showed higher fungal diversity in continuously cropped fields compared to fallow fields across two seasons (winter and summer).
- The research identified various fungal phyla, with saprotrophs as the dominant type, and revealed that understanding these microbial communities could help address continuous cropping challenges and support sustainable development in agriculture.
Aberrantly expressed long noncoding RNAs (lncRNAs) play crucial roles in the process of breast cancer (BC). This research aims to dig the possible roles and regulatory mechanism of lncRNA protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P1) in BC. The mRNA level of PDIA3P both in BC tissues and in cells were determined, followed by the investigation of the effects of PDIA3P suppression on cell biological processes including the viability, apoptosis, migration and invasion.
View Article and Find Full Text PDFThis study aimed to explore the role and mechanism of lncRNA small nucleolar RNA host gene 12 (SNHG12) in the development of prostate cancer (PCa). The expression of SNHG12 in the serum of PCa patients as well as PCa cells was determined, and then we investigated whether SNHG12 could act as a competing endogenous RNA (ceRNA) to mediate the development of PCa. Furthermore, the association between SNHG12 and activation of the PI3K/AKT/mTOR pathway was explored.
View Article and Find Full Text PDFMicroRNA-183 affects the development of gastric cancer by regulating autophagy via MALAT1-miR-183-SIRT1 axis and PI3K/AKT/mTOR signals.
Artif Cells Nanomed Biotechnol
December 2019
Gastric cancer (GC) remains to be a familiar malignant tumor with poor prognosis and daunting impacts on global health. We planned to grab the latent impacts of microRNA-183 in regulating cell autophagy, thus to clarify its possible regulatory principle in GC. The miR-183 level in GC tissues and cell lines was investigated.
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- This study investigates the role of transcription factor 12 (TCF12) in gastric cancer (GC), highlighting its expression levels in cancerous tissues compared to normal ones using data from The Cancer Genome Atlas (TCGA).
- The findings indicate that high levels of TCF12 correlate with poor patient prognosis and that inhibiting TCF12 reduces cell proliferation, migration, invasion, and increases apoptosis in gastric cancer cell lines.
- Additionally, TCF12 is linked to the PI3K/AKT signaling pathway and is regulated by miR-183, suggesting that targeting TCF12 could be a promising therapeutic strategy for treating gastric cancer.
Circulating tumor cells (CTCs) are important markers for cancer diagnosis and treatment, but it is still a challenge to recognize and isolate CTCs because they are very rare in the blood. To selectively recognize CTCs and improve the capture efficiency, micro/nanostructured substrates have been fabricated for this application; however the size of CTCs is often ignored in designing and engineering micro/nanostructured substrates. Herein, a spiky polymer micropillar array is fabricated for capturing CTCs with high efficiency.
View Article and Find Full Text PDFAnemone flaccida Fr. Shmidt (Ranunculaceae), known as 'Di Wu' in China, is a perennial herb which has long been used to treat arthritis. The rhizome of A.
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- Anemone flaccida, a medicinal herb from China known for its rhizome used to treat arthritis, has a rich source of triterpenoid saponins, but its biosynthesis remains largely unexplored.
- This study utilized tandem transcriptome and proteome profiling to analyze A. flaccida, identifying 46,962 high-quality unigenes and 1,473 unique proteins, revealing significant gene expression differences between rhizomes and leaves.
- Bioinformatics analysis identified key pathways and enzymes in triterpenoid saponin biosynthesis, including the mevalonate and methylerythritol pathways, highlighting important cytochrome P450s and UDP glycos
Article Synopsis
- * Through transcriptome analysis using short read sequencing, the researchers identified over 62,000 unigenes, uncovering key enzymes involved in the biosynthesis of sesquiterpenoids.
- * The findings contribute valuable data for future research on A. lancea, especially in gene mining related to terpenoids and other important medicinal compounds.
[A new exploration of the applicability of the head injury criterion].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
December 2007
Article Synopsis
- Head Injury Criterion (HIC) is a key measure used to evaluate the risk of head injuries from external forces, especially in vehicle safety and helmet design.
- A study examined two human head models with different sizes and weights to see how well HIC applies across various impact scenarios.
- By analyzing the stress on the brains of the models in relation to HIC values, the research offers new insights and conclusions about HIC's effectiveness in assessing head injuries.