Publications by authors named "Xueke Bai"
Article Synopsis
- * The study analyzed data from over 1 million participants aged 35-75 across 453 districts and found a notable increase in mortality risk associated with low area-level SES, especially among older adults, women, and those with low individual SES.
- * The research reveals that both area-level and individual-level SES are important determinants of health, suggesting that improving community resources could help reduce mortality disparities.
Evidence of the associations between long-term exposure to PM and O and human blood lipid concentrations is abundant yet inconclusive. Whether clean air policies could improve lipid profiles remains unclear. In total, 2979312 participants from a Chinese nationwide prospective study were included.
View Article and Find Full Text PDFBackground: The triglyceride-glucose (TyG) index has been recognized as a crucial risk factor for cardiovascular diseases. However, the association between the TyG index and mortality in the general population remains elusive.
Methods: Participants were enrolled from the China Health Evaluation And risk Reduction through nationwide Teamwork (ChinaHEART), a nationwide prospective cohort study.
Importance: Limited evidence supports the association between low-density lipoprotein cholesterol (LDL-C) and mortality across different atherosclerotic cardiovascular disease (ASCVD) risk stratifications.
Objective: To explore the associations between LDL-C levels and mortality and to identify the optimal ranges of LDL-C with the lowest risk of mortality in populations with diverse ASCVD risk profiles.
Design, Setting, And Participants: The ChinaHEART project is a prospective cohort study that recruited residents aged 35 to 75 years from 31 provinces in mainland China between November 2014 and December 2022.
Titanium dioxide nanoparticles (nTiO) have been considered a possible carcinogen to humans, but most existing studies have overlooked the role of human enzymes in assessing the genotoxicity of nTiO. Here, a toxicogenomics-based in vitro genotoxicity assay using a GFP-fused yeast reporter library was employed to elucidate the genotoxic potential and mechanisms of nTiO. Moreover, two new GFP-fused yeast reporter libraries containing either human CYP1A1 or CYP1A2 genes were constructed by transformation to investigate the potential modulation of nTiO genotoxicity in the presence of human CYP enzymes.
View Article and Find Full Text PDFObjective: To examine the joint association of healthy lifestyles and statin use with all-cause and cardiovascular mortality in high-risk individuals, and evaluate the survival benefits by life expectancy.
Methods: During 2015-2021, participants aged 35-75 years were recruited by the China Health Evaluation And risk Reduction through nationwide Teamwork. Based on number of healthy lifestyles related to smoking, alcohol drinking, physical activity, and diet, we categorized them into: very healthy (3-4), healthy (2), and unhealthy (0-1).
Introduction: Exploring sociodemographic effect modification is important to provide evidence for developing targeted recommendations and reducing health inequalities. This study evaluated how sociodemographic factors including age, sex, race/ethnicity and socioeconomic status (SES) modify the association between leisure-time physical activity (LTPA) and all-cause and major cause-specific mortality.
Methods: The study sample included 471,992 people from the 1997-2018 National Health Interview Survey (NHIS) and 41,830 people from the 1999-2018 National Health and Nutrition Examination Survey (NHANES).
Objective: Daytime napping has been reported to have a potential association with an increased risk of cardiovascular diseases (CVDs) in several cohort studies, but the causal effects are unclear. In this study, we aimed to investigate the relationship between daytime napping and CVDs, as well as to validate causality in this relationship by Mendelian randomization (MR).
Methods: A two-sample MR method was used to evaluate the causal effect of daytime napping on CVDs.
Background: Since 2010, China has made vast financial investments and policy changes to the primary care system. We aimed to assess how hypertension awareness, treatment, and control might be used to assess quality of primary care systems, which reflect the outcomes of public health services and medical care.
Methods: We used The China Patient-centred Evaluative Assessment of Cardiac Events Million Persons Project, a government-funded public health project that focuses on cardiovascular disease risk in China.
Article Synopsis
- A rising number of patients in hospitals with heart failure (HF) are diagnosed with HF with preserved ejection fraction (HFpEF), prompting research into effective prognostic biomarkers like growth differentiation factor 15 (GDF-15).
- This study evaluated serum GDF-15 levels in 380 hospitalized HFpEF patients to predict their risk of death and heart failure readmission within one year, finding significant correlations.
- GDF-15 showed better predictive accuracy for outcomes compared to the existing NT-proBNP model, indicating its potential as a valuable biomarker for managing HFpEF in clinical settings.
Background: Elevated blood pressure (BP) is associated with substantial morbidity and mortality in stroke survivors. China has the highest prevalence of stroke survivors and accounts for one-third of stroke-related deaths worldwide. We aimed to describe the prevalence and treatment of elevated BP across age, sex, and region, and assess the mortality attributable to elevated BP among stroke survivors in China.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the impact of non-cardiac comorbidities on long-term outcomes and quality of life (QoL) in patients hospitalized for heart failure (HF) in China.
- It found that patients with three or more non-cardiac comorbidities faced significantly higher risks of death and rehospitalization compared to those without any comorbidities.
- Despite overall improvements in QoL among all HF patients after discharge, those with multiple comorbidities reported notably lower scores on the Kansas City Cardiomyopathy Questionnaire, indicating poorer health status.
Article Synopsis
- High systolic blood pressure (SBP) is linked to poor health outcomes in patients with heart failure (HF), and this study aimed to clarify how SBP affects long-term prognosis for those hospitalized with HF.
- Researchers included 4,564 adult patients from 52 hospitals in China and assessed SBP at discharge, tracking rates of 1-year all-cause death and HF readmission.
- Results showed that SBP levels below 110 mmHg and above 150 mmHg significantly increased risks for both death and readmission, indicating a J-curve relationship with optimal SBP around 130 mmHg.
Article Synopsis
- The study explores how the discharge heart rate of hospitalized heart failure patients with atrial fibrillation impacts their clinical outcomes after one year, especially looking at whether this relationship varies based on left ventricular ejection fraction (LVEF).
- A total of 1,760 patients were categorized into three heart rate groups: low (<65 bpm), moderate (65-85 bpm), and high (≥86 bpm).
- Results showed that both low and high discharge heart rates were linked to a greater risk of death or rehospitalization within a year compared to moderate heart rates, with notable differences observed based on LVEF levels.
Article Synopsis
- Heart failure with preserved ejection fraction (HFpEF) is a significant public health issue that lacks effective ways to assess patient risk.
- The study analyzed 18 biomarkers in 380 hospitalized patients to predict the 2-year risk of all-cause death, using techniques like Cox regression and a machine learning method called support vector machine (SVM).
- Results showed that certain biomarkers can effectively predict mortality risk, and the SVM model significantly improved patient classification over traditional methods, indicating its potential for better risk assessment in HFpEF.
Article Synopsis
- The study investigates the characteristics and management of valvular heart disease (VHD) in China, focusing on patient demographics, aetiology, and outcomes for those hospitalised in 2015.
- A national sample of 9,363 VHD patients was analyzed, revealing that the average age was 68.7 years, with degenerative conditions being the most common cause overall, while rheumatic origins were prevalent among those with primary VHD diagnoses.
- The findings highlight that mitral regurgitation was the most common type of VHD and that only 35.6% of patients with severe VHD required valve intervention in hospitals equipped for such procedures.
Objective: To assess the association between beta-blockers and 1-year clinical outcomes in heart failure (HF) patients with atrial fibrillation (AF), and further explore this association that differs by left ventricular ejection fraction (LVEF) level.
Methods: We enrolled hospitalized HF patients with AF from China Patient-centered Evaluative Assessment of Cardiac Events Prospective Heart Failure Study. COX proportional hazard regression models were employed to calculate hazard ratio of beta-blockers.
Article Synopsis
- A study in China from 2011 to 2015 analyzed national changes in patient characteristics, management, and outcomes for STEMI patients, revealing that while the overall number of STEMI patients increased, their proportion among those with acute myocardial infarction decreased.
- The proportion of patients eligible for reperfusion treatment declined due to increasing prehospital delays, although the actual percentage of treated patients who received such therapies improved.
- Despite advancements in acute care, the rates of in-hospital mortality remained steady, indicating a continued need for improved prevention strategies and efforts to reduce delays in treatment.
Objectives: This study aims to examine the association between the Kansas City Cardiomyopathy Questionnaire (KCCQ)-12 score and the 30-day and 1-year rates of composite events of cardiovascular death and heart failure (HF) rehospitalization in patients with acute HF.
Background: Few studies reported the prognostic effects of KCCQ in acute HF.
Methods: This study prospectively enrolled adult patients hospitalized for HF from 52 hospitals in China and collected the KCCQ-12 score within 48 hour of index admission.
Article Synopsis
- The study focuses on developing and validating a risk prediction model for patients hospitalized with acute myocardial infarction (AMI) in China to enhance clinical decision-making and resource management.
- Researchers used data from multiple studies, including 8,010 patients for model development and additional samples for validation, to identify the likelihood of in-hospital major adverse cardiovascular events (MACE).
- Results showed that nine clinical factors significantly predicted MACE, and the model demonstrated strong performance in both accuracy and reliability, indicating its potential usefulness in clinical settings.
Objectives: To develop a model of in-hospital mortality using medical record front page (MRFP) data and assess its validity in case-mix standardisation by comparison with a model developed using the complete medical record data.
Design: A nationally representative retrospective study.
Setting: Representative hospitals in China, covering 161 hospitals in modelling cohort and 156 hospitals in validation cohort.
Article Synopsis
- Qingfei Paidu Tang (QPT), a traditional Chinese medicine, is commonly used in China for treating COVID-19, but its effect on mortality rates was previously unclear.
- A retrospective study analyzed data from 8,939 hospitalized COVID-19 patients and found that those using QPT had a significantly lower mortality rate (1.2%) compared to those not using it (4.8%).
- After adjusting for other variables, QPT use was associated with a 50% reduction in in-hospital mortality, with consistent results across different demographic groups and similar rates of liver and kidney injuries between the two patient groups.
β-blocker and 1-year outcomes among patients hospitalized for heart failure with mid-range ejection fraction.
Eur Heart J Cardiovasc Pharmacother
February 2022
Aims: The beneficial effect of β-blocker on heart failure with reduced ejection fraction is well established. However, its effect on the 1-year outcome of heart failure with mid-range ejection fraction (HFmrEF) remains unclear.
Methods And Results: We analysed the data of the patients with left ventricular ejection fraction (LVEF) between 40% and 49% in China Patient-centred Evaluative Assessment of Cardiac Events Prospective Heart Failure Study (China PEACE 5p-HF Study), in which patients hospitalized for heart failure from 52 Chinese hospitals were recruited from 2016 to 2018.
Article Synopsis
- The study investigates the impact of angiotensin receptor blockers (ARBs) on 1-year all-cause mortality in patients with heart failure and mid-range ejection fraction (HFmrEF).
- Data from 701 hospitalized patients in China revealed that those treated with ARB had significantly lower mortality rates (11.5%) compared to those not treated (21.9%) within a year.
- The findings suggest that ARB use is linked to reduced all-cause mortality in HFmrEF patients after discharge, highlighting its potential benefits in treatment.
Objective: In 2001, Chinese guidelines for the care of acute myocardial infarction (AMI) included a new recommendation against the routine use of magnesium. We studied temporal trends and institutional variation in the use of intravenous magnesium sulfate in nationally representative samples of individuals hospitalised with AMI in China between 2001 and 2015.
Methods: In an observational study (China PEACE-Retrospective Study) of AMI care, we used a two-stage, random sampling strategy to create a nationally representative sample of 28 208 patients with AMI at 162 Chinese hospitals in 2001, 2006, 2011 and 2015.