Characterizing Vericiguat Treatment in Heart Failure: A Multicenter Real-World Study in China.

Background: Real-world data on the clinical benefit of vericiguat are currently limited. This multicenter, real-world study was conducted to evaluate the clinical characteristics and therapeutic effects of vericiguat in real-world settings.

Methods: This study analyzed heart failure (HF) patients who initiated vericiguat treatment from September 2022 to August 2023 across nine hospitals in the Anhui Province, China.

Causal correlations between inflammatory proteins and heart failure: A two-sample Mendelian randomization analysis.

Aims: Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation-related proteins and HF risk remains unclear. This study aims to investigate the genetically supported causality between inflammatory proteins and HF using a two-sample Mendelian randomization (MR) analysis.

Exploring the mediating role of calcium homeostasis in the association between diabetes mellitus, glycemic traits, and vascular and valvular calcifications: a comprehensive Mendelian randomization analysis.

Background: The interplay between diabetes mellitus (DM), glycemic traits, and vascular and valvular calcifications is intricate and multifactorial. Exploring potential mediators may illuminate underlying pathways and identify novel therapeutic targets.

Methods: We utilized univariable and multivariable Mendelian randomization (MR) analyses to investigate associations and mediation effects.

An intriguing case of regular RR and QRS alternans during idiopathic left posterior fascicle ventricular tachycardia.

This study represents a case of idiopathic left posterior fascicle ventricular tachycardia (LPF-VT), which is intriguing due to regular alternation of short-long RR intervals and QRS morphology. Transthoracic echocardiogram analysis did not detect any structural heart disease. A baseline electrophysiological study was performed.

[An overview of phylogenetic relationship between Mus and Microtus].

Muriod is the most successful one among rodents struggling for existence, and biologists have been paying much attention to it, especially Mus musculus. Because of the thorough study on Mus musculus, it has been widely applied in lab, and becomes a good material for studying other animals. Phylogenetic relationship between different species and populations of Mus and Microtus are more clearly revealed with some genetic markers of modern genetics, such as protein, mtDNA, and rDNA.

Sex determination of Microtus mandarinus mandarinus is independent of Sry gene.

PCR was performed with primers corresponding to the Sry HMG-box of the mouse and eight Microtus species. Primers for the SALL4 gene and the ZFY/ZFX gene were used as positive controls. None of these sets of primers can amplify any homologous segment of the Sry gene in the genomic DNA of Microtus mandarinus mandarinus, but both can amplify the Sry HMG-box in the male mouse, SALL4 bands, and ZFY/ZFX bands in both male and female M.