Efficient mRNA Delivery In Vitro and In Vivo Using a Polycharged Biodegradable Nanomaterial.

As RNA rises as one of the most significant modalities for clinical applications and life science research, efficient tools for delivering and integrating RNA molecules into biological systems become essential. Herein, we report a formulation using a polycharged biodegradable nano-carrier, N1-501, which demonstrates superior efficiency and versatility in mRNA encapsulation and delivery in both cell and animal models. N1-501 is a polymeric material designed to function through a facile one-step formulation process suitable for various research settings.

Reactive Synthesis for Porous (MoY)AlC Ceramics through Mo, Y, Al and Graphite Powders.

Through an activation reaction sintering method, porous (MoY)AlC ceramics were prepared by Mo, Y, Al, and graphite powders as raw materials. The phase composition, microstructure, element distribution, and pore structure characteristics were comprehensively studied using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), Archimedes method, and bubble point method. A detailed investigation was conducted on the influence of sintering temperature on the phase composition.

Investigating the effect of welding tool length on mechanical strength of welded metallic matrix by molecular dynamics simulation.

The welding process and the properties of welding instruments may improve the mechanical performance of an item. One of these properties is the length of the welding tool. This approach has a substantial effect on the mechanical strength of the metallic matrix.

Impact of Sintering Temperature Variation on Porous Structure of MoTiAlC Ceramics.

Mo, TiH, Al and graphite elemental powders were used as starting materials for the activation reaction sintering process, which was employed to fabricate porous MoTiAlC. The alteration of phase constitution, volume expansion, porosity, pore size and surface morphology of porous MoTiAlC with sintering temperatures ranging from 700 °C to 1500 °C were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and pore size tester. Both the pore formation mechanism and activation reaction process at each temperature stage were investigated.

Preparation of Ce-MnO Composite Oxides via Coprecipitation and Their Catalytic Performance for CO Oxidation.

Ce-MnO composite oxide catalysts with different proportions were prepared using the coprecipitation method, and the CO-removal ability of the catalysts with the tested temperature range of 60-140 °C was investigated systematically. The effect of Ce and Mn ratios on the catalytic oxidation performance of CO was investigated using X-ray diffraction (XRD), X-ray energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), H temperature programmed reduction (H-TPR), CO-temperature programmed desorption (CO-TPD), and in situ infrared spectra. The experimental results reveal that under the same test conditions, the CO conversion rate of pure MnO reaches 95.

Effects of Tai Chi on Lung Function, Exercise Capacity and Psychosocial Outcomes in Patients With Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-analysis of Randomized Controlled Trials.

To explore whether tai chi can improve lung function, exercise capacity, and health-related outcomes in patients with chronic obstructive pulmonary disease (COPD). The PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure (CNKI), Wanfang, and China Science and Technology Journal Database (VIP) databases were searched from inception to January 5, 2023. The methodological quality of the included studies was evaluated according to the Cochrane Handbook for Systematic Reviews of Interventions criteria.

C-H Functionalization and Allylic Amination for Post-Polymerization Modification of Polynorbornenes.

Post-polymerization modification (PPM) via direct C-H functionalization is a powerful synthetic strategy to convert polymer feed-stocks into value-added products. We found that a metal-free, Se-catalyzed allylic C-H amination provided an efficient method for PPM of polynorbornenes (PNBs) produced via ring-opening metathesis polymerization. Inherent to the mechanism of the allylic amination, PPM on PNBs preserved the alkene functional groups along the polymer backbone, while also avoiding transposition of the double bonds.

Two Birds with One Stone: Copper-Based Adsorbents Used for Photocatalytic Oxidation of Hg (Gas) after Removal of PH.

Cu/TiO adsorbents with CuO as the active component were prepared via a simple impregnation method for efficient purification of phosphine (PH) under the conditions of low temperatures (90 °C) and low oxygen concentration (1%). The PH breakthrough capacity of optimal adsorbent (Cu/TiO) is 136.2 mg(PH)·g, and the excellent dephosphorization performance is mainly attributed to its abundant sur face-active oxygen and alkaline sites, large specific surface area, and strong interaction between CuO and the support TiO.

Resource utilization of hazardous solid waste blast furnace dust: Efficient wet desulfurization and metal recovery.

Hazardous solid waste blast furnace dust (BFD) is rich in valuable metal components such as iron (Fe), zinc (Zn), manganese (Mn), and its recycling or harmless treatment is a major challenge. This paper creatively proposes the strategy of "treating waste with waste" by using BFD for desulfurization. The experimental results show that BFD slurry can achieve high-efficiency desulfurization and recovery of Zn resources.

Bio-Nanohybrid Cell Based Signal Amplification System for Electrochemical Sensing.

A signal amplification system for electrochemical sensing was established by bio-nanohybrid cells (BNC) based on bacterial self-assembly and biomineralization. The BNC was constructed by partially encapsulating a MR-1 cell with the self-biomineralized iron sulfide nanoparticles. The iron sulfide nanoparticle encapsulated BNCs showed high transmembrane electron transfer efficiency and was explored as a superior redox cycling module.

Enhancement of photo-driven biomethanation under visible light by nano-engineering of Rhodopseudomonas palustris.

Biomethanation is of great interest as it can transform CO to methane under ambient conditions. In particular, genetically engineered bacterium of Rhodopseudomonas palustris showed great promise for one-step biomethanation powered by solar energy, which is attractive for CO fixation as well as solar energy storage. However, biomethanation with R.

An Ion-Pairing Approach to Stereoselective Metal-Free Ring-Opening Metathesis Polymerization.

Stereochemistry can have a profound impact on polymer and materials properties. Unfortunately, straightforward methods for realizing high levels of stereocontrolled polymerizations are often challenging to achieve. In a departure from traditional metal-mediated ring-opening metathesis polymerization (ROMP), we discovered a remarkably simple method for controlling alkene stereochemistry in photoredox mediated metal-free ROMP.

A Trefoil Macrocycle Synthesized by 3-Fold Benzannulation.

A new trefoil-shaped molecular architecture consisting of three conjugated macrocycles was synthesized through an unprecedented 3-fold copper catalyzed [4 + 2] benzannulation. DFT calculations indicate that the most stable conformation of this trefoil macrocycle is D-symmetric. In agreement with the calculated results, the trefoil macrocycle in single crystals exists as a pair of enantiomers with D-symmetry and exhibits interesting honeycomb-like supramolecular structures.

Benzo[4,5]cyclohepta[1,2-]fluorene: an isomeric motif for pentacene containing linearly fused five-, six- and seven-membered rings.

Benzo[4,5]cyclohepta[1,2-]fluorene (), a new π-conjugated polycyclic hydrocarbon containing linearly fused six-, five-, six-, seven- and six-membered rings (C-C-C-C-C), was designed and its stable derivatives and were synthesized. With 22 π electrons, is an isomer of pentacene with quinoidal, dipolar ionic and diradical resonance forms. Molecules and were experimentally investigated with cyclic voltammetry, electronic absorption spectroscopy and X-ray crystallographic analysis, and theoretically studied by calculating the NICS value, diradical character and dipole moment.

Solution-Processed Ambipolar Organic Thin-Film Transistors by Blending p- and n-Type Semiconductors: Solid Solution versus Microphase Separation.

Here, we report solid solution of p- and n-type organic semiconductors as a new type of p-n blend for solution-processed ambipolar organic thin film transistors (OTFTs). This study compares the solid-solution films of silylethynylated tetraazapentacene 1 (acceptor) and silylethynylated pentacene 2 (donor) with the microphase-separated films of 1 and 3, a heptagon-embedded analogue of 2. It is found that the solid solutions of (1)x(2)1-x function as ambipolar semiconductors, whose hole and electron mobilities are tunable by varying the ratio of 1 and 2 in the solid solution.

Heptagon-embedded pentacene: synthesis, structures, and thin-film transistors of dibenzo[d,d']benzo[1,2-a:4,5-a']dicycloheptenes.

This study presents a new class of conjugated polycyclic molecules that contain seven-membered rings, detailing their synthesis, crystal structures and semiconductor properties. These molecules have a nearly flat C6-C7-C6-C7-C6 polycyclic framework with a p-quinodimethane core. With field-effect mobilities of up to 0.