Comprehensive analysis of CLEC family genes in gastric cancer prognosis immune response and treatment.

Gastric cancer, a prevalent malignancy, often presents challenges due to its low early diagnosis rate and poor prognosis. This study aims to establish a prognostic model composed of genes from the CLEC family, aiming to predict the prognosis of gastric cancer patients effectively. Data Collection: mRNA expression matrices and clinical data were downloaded from the TCGA, GEO, and GTEx databases.

Five racemic phthalides from the aerial parts of Lycopodiastrum casuarinoides and their neuroprotective activities.

Five racemic phthalides (1-5), including four undescribed phthalides monomers [(+)-1, (+)-2, (-)-2 and (-)-3], four undescribed phthalide dimers [(+)-4, (-)-4, (+)-5 and (-)-5], together with two known compounds [(-)-1 and (+)-3], were isolated from the aerial parts of Lycopodistrum casuarinoides. Their chemical structures were delineated by extensive spectroscopic data (UV, 1D/2D NMR, HRESIMS), in combination with the comparison of the experimental and calculated electronic circular dichroism spectra, calculated spin-spin coupling constants, and calculated NMR. All compounds were reported from Lycopodiaceae family for the first time.

Design and study of an eccentric wheel drive-based rotating piezoelectric energy harvester.

A nonlinear rotating piezoelectric energy harvester (N-RPEH) driven by eccentric wheels is proposed to collect rotational energy in the environment. Driven by external rotational motion, an eccentric wheel converts rotational motion into linear motion and realizes electrical energy output through magnetic coupling. To increase the effectiveness of the equipment's energy conversion process, this article aims to transform the rotational motion of an eccentric wheel into a linear motion of a motion board.

A novel energy harvester based on dual vibrating mechanisms with self-actuation.

This paper introduced a novel energy harvester with a tunnel and drop-shaped bluffbody for self-actuation and wind speed sensing. The harvester exhibits dual vibrating mechanisms of vortex-induced vibration (VIV) and galloping. Theoretical and numerical analyses were conducted to study the energy conversion relationship and fluid field of the harvester, and the conclusions were verified by controlled variable experiments.

Piezoelectric energy harvesting systems using mechanical tuning techniques.

In this review, we review the recent research progress and results of piezoelectric energy harvesters applying mechanical tuning techniques in terms of literature background, methods of mechanical tuning, and practical applications. In the past few decades, piezoelectric energy harvesting techniques and mechanical tuning techniques have received increasing attention and made significant progress. Mechanical-tuning techniques are those that allow the resonant vibration energy harvesters the mechanical resonant frequency values to be adjusted to coincide with the excitation frequency.

Baduanjin improves neck pain and functional movement in middle-aged and elderly people: A systematic review and meta-analysis of randomized controlled trials.

Background: Neck pain (NP), one of the most common musculoskeletal diseases, exercises a great influence on the daily life of individuals, especially the elderly. Baduanjin is a traditional Qigong therapy from China, but there is no evidence for its use in the treatment of neck pain in middle-aged and elderly people.

Objective: We hope to summarize the efficacy evidence of Baduanjin in the treatment of middle-aged and elderly patients with neck pain (NP) for the first time, conduct a systematic review and meta-analysis, and provide basic evidence-based evidence for clinical practice.

Therapeutic Role of Additional Mirror Therapy on the Recovery of Upper Extremity Motor Function after Stroke: A Single-Blind, Randomized Controlled Trial.

Background: Rehabilitation of upper extremity hemiplegia after stroke remains a great clinical challenge, with only 20% of patients achieving a basic return to normal hand function. How to promote the recovery of motor function at an early stage is crucial to the life of the patient.

Objectives: To invest the effects of additional mirror therapy in improving upper limb motor function and activities of daily living in acute and subacute stroke patients, and further explore the effects of other factors on the efficacy of MT.

Effectiveness of Taijiquan in treating insomnia: A systematic review and meta-analysis of randomized controlled studies.

Background: Sleep efficiency of <80% based on actigraphy was defined as insomnia as self-reported difficulty falling asleep or waking up at night three to four times per week. It is known that adequate sleep is very important for human wellbeing, affecting people's work and life, insomnia will seriously damage our daily life. There is no recognized non-drug treatment.

USP25 UPREGULATION BOOSTS GSDMD -MEDIATED PYROPTOSIS OF ACINAR CELLS IN ACUTE PANCREATITIS.

Acute pancreatitis (AP) is an inflammation-associated disorder in the digestive system. Ubiquitin-specific peptidase 25 ( USP25 ) can modulate inflammation in diseases. This study expounded on the role of USP25 in pyroptosis of acinar cells in AP.

Simulation and Experimental Investigation of the Vacuum-Enhanced Direct Membrane Distillation Driven by a Low-Grade Heat Source.

Vacuum-enhanced direct contact membrane distillation (VEDCMD) has been proven experimentally to improve the permeate flux, compared with direct contact membrane distillation (DCMD). However, the theoretical mechanism for its transmembrane transfer process has not been revealed sufficiently. In this paper, with full consideration of the different driving forces of diffusion and Poiseuille flow under the vacuum enhancing condition, a theoretical transmembrane model for mass and heat transfer in VEDCMD is proposed.

The Effect of Repetitive Transcranial Magnetic Stimulation in Synchronization with Effortful Swallowing on Post-stroke Dysphagia.

Either effortful swallowing exercise or repetitive transcranial magnetic stimulation (rTMS) is considered as an effective method to treat dysphagia after stroke. Thus, synchronizing these two interventions may improve the efficiency of treatment. This trial intended to explore the effects of rTMS and effortful swallowing exercise on the recovery of swallowing function in patients after stroke.

Lower risk of gout in sodium glucose cotransporter 2 (SGLT2) inhibitors versus dipeptidyl peptidase-4 (DPP4) inhibitors in type-2 diabetes.

Objectives: The effects of sodium-glucose cotransporter 2 inhibitors (SGLT2I) vs dipeptidyl peptidase-4 inhibitors (DPP4I) on the risk of new-onset gout remains unknown. This study aims to compare the effects of SGLT2I against DPP4I on gout risks.

Methods: This was a retrospective population-based cohort study of patients with type-2 diabetes mellitus treated with SGLT2I or DPP4I between 1 January 2015 and 31 December 2020 in Hong Kong.

The effects of physiotherapy treatments on dysphagia in Parkinson's disease: A systematic review of randomized controlled trials.

Background: The prevalence of swallowing disorders in Parkinson's disease (PD) is relatively high. Different physiotherapy interventions for swallowing disorders are available but there is a lack of evidence-based medicine for their effectiveness in PD.

Objective: The purpose of this systematic review was to investigate the effects of different physiotherapy interventions on dysphagia in PD.

A hemicyanidin-based NIR fluorescent probe for detection of HS and imaging study in cells and mice.

The selective detection of hydrogen sulfide in physiological and pathological processes has gained substantial attention in recent years. However, the real-time detection of hydrogen sulfide remains an elusive goal. In this work, a new type of hemicyanidin-based fluorescent "turn-on" probe NTR-HS (Ex = 680 nm, Em = 760 nm) was developed to detected HS in a very short time (3 min).

Risk of New-Onset Prostate Cancer for Metformin Versus Sulfonylurea Use in Type 2 Diabetes Mellitus: A Propensity Score-Matched Study.

Background: The aim of this study was to compare the risks of new-onset prostate cancer between metformin and sulfonylurea users with type 2 diabetes mellitus (T2DM).

Methods: This population-based retrospective cohort study included male patients with T2DM presenting to public hospitals/clinics in Hong Kong between January 1, 2000, and December 31, 2009. We only included patients prescribed either, but not both, metformin or sulfonylurea.

A Novel Ocean Thermal Energy Driven System for Sustainable Power and Fresh Water Supply.

The ocean thermal energy conversion (OTEC) is a potential substitute for traditional power plants in tropical islands and coastal regions. However, the OTEC power generation cycle has low thermal efficiency and the integrated utilization is imperative, in which an OTEC coupled with seawater desalination is the most attractive option. Membrane distillation (MD) has distinct advantages making itself a competitive process for seawater desalination, especially the feature that the drained warm seawater from the OTEC power plant can be recycled, improving the integrated output of the OTEC system.

Hip fractures risks in edoxaban versus warfarin users: A propensity score-matched population-based cohort study with competing risk analyses.

Objective: The three direct oral anticoagulants (DOAC), rivaroxaban, apixaban and dabigatran have been associated with lower risks of fractures compared to warfarin. However, no large scale studies have explored the associations with the newest DOAC, edoxaban, with fracture risk. The present study aims to elucidate the effects of edoxaban on the risk of hip fracture amongst elderly patients by comparing the incidence of new onset hip fracture between edoxaban and warfarin users in a Chinese population.

Errata: Spectral response model for a multibin photon-counting spectral computed tomography detector and its applications.

[This corrects the article DOI: 10.1117/1.JMI.

Spectral response model for a multibin photon-counting spectral computed tomography detector and its applications.

Variations among detector channels in computed tomography can lead to ring artifacts in the reconstructed images and biased estimates in projection-based material decomposition. Typically, the ring artifacts are corrected by compensation methods based on flat fielding, where transmission measurements are required for a number of material-thickness combinations. Phantoms used in these methods can be rather complex and require an extensive number of transmission measurements.

Energy-resolved CT imaging with a photon-counting silicon-strip detector.

Photon-counting detectors are promising candidates for use in the next generation of x-ray computed tomography (CT) scanners. Among the foreseen benefits are higher spatial resolution, better trade-off between noise and dose and energy discriminating capabilities. Silicon is an attractive detector material because of its low cost, mature manufacturing process and high hole mobility.

Cell-permeable Tat-NBD peptide attenuates rat pancreatitis and acinus cell inflammation response.

Aim: To investigate the effects of Tat-NEMO-binding domain (NBD) peptide on taurocholate-induced pancreatitis and lipopolysaccharide (LPS)-stimulated AR42J acinus cells inflammatory response in rats.

Methods: Sodium taurocholate (5%) was used to induce the pancreatitis model. Forty-eight rats from the taurocholate group received an intravenous bolus of 13 mg/kg Tat-NBD (wild-type, WT) peptide, Tat-NBD (mutant-type, MT) peptide, NBD peptide or Tat peptide.