Publications by authors named "Xuejie Liu"

Self-assembly of block copolymers (BCPs) into anisotropic colloidal particles within 3D emulsion droplets has attracted considerable interest since the confined assembly in deformable geometries offers significant potential for designing and constructing specific anisotropic polymer materials for various applications. By precisely controlling the deformation of emulsion droplets, nucleation, and deposition sequence of BCP segments at the oil/water interface, various anisotropic polymer assembly particles with tunable shapes and internal structures can be generated. This review summarizes the recent advancements in the design and formation of anisotropic polymer assembly particles via confined assembly of BCPs, including an overview of emulsification techniques and methods, the regulation of particle shapes and internal structures, as well as the diverse applications of resulting anisotropic particles.

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Influenza B virus (IBV) causes annual respiratory outbreaks, posing significant public health challenges. Traditional vaccines are limited in their effectiveness by antigenic drift and strain mismatches. This study introduces innovative mosaic virus-like particle (VLP) vaccines designed to present a broader range of epitopes, aiming for broad-spectrum immunity against both B/Victoria (BV) and B/Yamagata (BY) IBV lineages in mice.

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Self-organization of anisotropic nanostructures into polymer/inorganic superstructures are of great research interest for various applications owing to their enhanced directional properties, such as plasmonics and catalysis. However, the controllable assembly and oriented growth of nanorods in solution without external template assistance remains a great challenge. Here, we report a facile Hofmeister-effect-based assembly strategy for fabricating ordered arrangements of polyethylene glycol-tethered gold nanorods (AuNRs@PEG) with controlled orientation and dimension.

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Current analgesics on the market exhibit a short duration of action and induce the production of inflammatory factors in tissues damaged by surgical procedures. Inflammatory factor production can create acidic environments, limiting drug delivery. In this study, we developed a novel injectable formulation comprising bupivacaine multivesicular liposomes of high osmotic pressure (H-MVL) and meloxicam nanocrystals (MLX) in a thermosensitive gel (H-MVL/MLX@GEL) adapted to the microenvironment for long-term postoperative analgesia.

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InSAR monitoring technology is widely used in investigating landslide hazards. Leveraging object detection algorithms to quickly extract landslide information from Wide-Area InSAR measurements is of great significance. Our InSAR-YOLOv8, an algorithm that automatically detects landslides from InSAR measurements, addresses the low accuracy and suboptimal detection performance of existing network models.

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A quadrangular prism-like oxidized tin sulfide catalyst with abundant sulfur vacancies was designed and synthesized for the COER. The quadrangular prism-like structure is utilized to increase the stability, while vacancy engineering is used to improve the activity and selectivity of the catalyst. The catalyst exhibits exceptional electrocatalytic activity for CO reduction to HCOO, achieving up to 95% faradaic efficiency for HCOO and maintaining stability for up to 36 hours at -1.

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Interferon-induced transmembrane proteins (IFITMs) are upregulated by interferons. They are not only highly conserved in evolution but also structurally consistent and have almost identical structural domains and functional domains. They are all transmembrane proteins and have multiple heritable variations in genes.

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The annual co-circulation of two influenza A subtypes, H1N1 and H3N2, viruses in humans poses significant public health threats worldwide. However, the continuous antigenic drift and shift of influenza viruses limited the effectiveness of current seasonal influenza vaccines, necessitating the development of new vaccines against both seasonal and pandemic viruses. One potential solution to this challenge is to improve inactivated vaccines by including multiple T-cell epitopes.

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Nanotechnology has emerged as a promising innovative avenue for therapeutic intervention in cancer research. However, achieving satisfactory accumulation of nanoparticles in the tumor and fabricating optimized nanoparticles remain challenging. In this work, we developed a novel polymeric micelle system to actively target integrin receptors, which are usually overexpressed in breast cancer.

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The gut microbiome is an important and the largest endocrine organ linked to the microbes of the GI tract. The bacterial, viral and fungal communities are key regulators of the health and disease status in a host at hormonal, neurological, immunological, and metabolic levels. The useful microbes can compete with microbes exhibiting pathogenic behavior by maintaining resistance against their colonization, thereby maintaining eubiosis.

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The physicochemical properties of Nemipterus virgatus surimi gel were investigated, with tremella powder (TP) at concentrations ranging from 0 to 0.5% (w/w) combined with continuous microwave heating (CMH) using water-bath heating (WBH) as control. Results showed that TP addition (0.

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Background: Influenza viruses pose a persistent threat to global public health, necessitating the development of innovative and broadly effective vaccines.

Methods: This study focuses on a multiepitope vaccine (MEV) designed to provide broad-spectrum protection against different influenza viruses. The MEV, containing 19 B-cell linear epitopes, 7 CD4 T cells, and 11 CD8 T cells epitopes identified through enzyme-linked immunospot assay (ELISPOT) in influenza viruses infected mice, was administered through a regimen of two doses of DNA vaccine followed by one dose of a protein vaccine in C57BL/6 female mice.

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Background: The effect of traditional disposable infant urine collectors is not ideal for female newborns. Due to the poor adhesion of the traditional urine collection bag, it does not meet the physiological and anatomical characteristics of female newborns. Therefore, it is necessary to adopt effective nursing in urine specimen collection in newborn female infants.

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Background: The clinical manifestations of COVID-19 range from asymptomatic, mild to moderate, severe, and critical disease. Host genetic variants were recognized to affect the disease severity. However, the genetic landscape differs among various populations.

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Some heavy metals are associated with periodontitis; whereas most of these associations have focused on individual metal, there are no specific studies on the effects of combined heavy metal exposure on periodontitis. We conducted an analysis on the association between urinary heavy metal exposure and periodontitis in participants aged 30 years and older using multiple logistic regression and Bayesian kernel machine regression (BKMR). This analysis was performed on data from the National Health and Nutrition Examination Survey from 2011 to 2014.

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Background: A growing number of studies have shown that prenatal exposure to chemical and non-chemical stressors has effects on fetal growth. The co-exposure of both better reflects real-life exposure patterns. However, no studies have included air pollutants and pregnancy-related anxiety (PrA) as mixtures in the analysis.

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Background: Evidence about effective psychoeducational interventions to improve prenatal attachment, anxiety and depression has been increasing, but it lacks a complete synthesis of the results. The aim of this study is to evaluate the effect of psychoeducational intervention on prenatal attachment and anxiety/depression in pregnant women and their partners.

Methods: Ten databases were systematically searched to identify randomized controlled trials (RCTs) on the effectiveness of psychoeducational interventions on prenatal attachment from inception to March 2023, then manually screened to include studies of anxiety or depression.

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The development of a universal influenza vaccine to elicit broad immune responses is essential in reducing disease burden and pandemic impact. In this study, the mosaic vaccine design strategy and genetic algorithms were utilized to optimize the seasonal influenza A virus (H1N1, H3N2) hemagglutinin (HA) and neuraminidase (NA) antigens, which also contain most potential T-cell epitopes. These mosaic immunogens were then expressed as virus-like particles (VLPs) using the baculovirus expression system.

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Polyhedral colloidal clusters assembled from functional inorganic nanoparticles have attracted great interest in both scientific research and applications. However, the spontaneous assembly of colloidal nanoparticles into polyhedral clusters with regular shape and tunable structures remains a grand challenges. Here, we successfully construct Mackay icosahedral and regular tetrahedral colloidal clusters assembled from gold nanoparticles grafted with a mixture of polystyrene (PS) and poly(2-vinylpyridine) (P2VP) homopolymers by precisely tuning the interfacial interaction between the nanoparticles and the oil/water interface.

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The combustion of cooking fuels generates detrimental gases significantly impacting human health, particularly for vulnerable populations like expectant mothers. Prenatal exposure of such hazardous emissions raises the probability of adverse pregnancy outcomes, including preterm birth (PTB) and low birth weight (LBW). Our research aims to explore the association between cooking fuel utilization and adverse birth outcomes in rural Ma'anshan, Anhui Province.

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Objective: Osteonecrosis of the femoral head (ONFH) is a disabling and intractable orthopedic disease largely affecting young and middle-aged groups. Current standard of treatment relies on the collapse of femoral head as a predictor for prognosis. However, a wide range of variability in repair potentials is observed in patients with femoral head collapse.

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Article Synopsis
  • Polymer dielectric capacitors need enhanced performance under high-temperature conditions due to increased conduction loss affecting energy density and efficiency.
  • A new bilayer polyimide (PI) composite film with an inorganic charge blocking layer was developed to improve charge trapping and mobility at high temperatures.
  • This innovative approach resulted in a high energy density of 4.37 J/cm³ and 92% efficiency at 200 °C, outperforming existing high-temperature dielectric materials.
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Vaccination is the most effective means of protecting people from influenza virus infection. The effectiveness of existing vaccines is very limited due to antigenic drift of the influenza virus. Therefore, there is a requirement to develop a universal vaccine that provides broad and long-lasting protection against influenza.

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