Publications by authors named "Xuejie Bao"
Gut microbial composition associated with risk of premature aging in women with Yin-deficiency constitution.
Front Cell Infect Microbiol
January 2025
Background: Yin-deficiency constitution (YinDC) refers to a traditional Chinese medicine concept, characterized by an imbalance state that includes an imbalance in the gut microbiota, resulting from a relative deficiency of Yin fluids within the body. In recent years, it has become apparent that the composition and structure of the gut microbiota play a significant role in the aging process. The imbalance of gut microbiota in YinDC may accelerate the aging process.
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- This study explores how Chinese herbs could potentially treat insomnia through techniques like data mining, network pharmacology, and molecular-docking validation.
- Researchers collected insomnia prescriptions from Qi Wang and used various databases to identify key medicinal herbs, active components, and relevant biological targets that contribute to the treatment.
- The analysis revealed 117 prescriptions with significant herbs, identified 6,417 differentially expressed genes connecting insomnia and healthy controls, and constructed a complex "transcription factor-miRNA-mRNA" network highlighting potential pathways involved in the therapeutic effects.
Context: Qing Cuo Formula (QCF) is a traditional Chinese medicine for treating acne, but its active compounds and molecular mechanisms are unclear.
Objective: To investigate the material basis and molecular mechanism of QCF.
Materials And Methods: experiments were conducted on 60 male golden hamsters with damp-heat acne, with a blank group, a spironolactone group and 3 QCF administration groups (given high, medium and low doses) over a 30-day period.