Publications by authors named "Xuejiao Duan"
Background: In intensive care units (ICU), mechanical ventilation (MV) is commonly applied to save patients' lives. However, ventilator-induced diaphragm dysfunction (VIDD) can complicate treatment by hindering weaning in critically ill patients and worsening outcomes. The goal of this study was to identify potential genes involved in the endogenous protective mechanism against VIDD.
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- Recent studies have found that Gram-negative bacteria can exist in the brain and may contribute to conditions like Alzheimer's disease (AD) through chronic neuroinflammation triggered by lipopolysaccharides (LPS).
- In an experiment with male Wistar rats, LPS injections led to depressive-like behaviors and impaired spatial learning, but no signs of typical AD pathology were observed for 10 months.
- The research indicates that chronic neuroinflammation from LPS may cause depressive symptoms and changes in cholesterol metabolism, suggesting that Gram-negative bacteria alone might not fully explain the onset of AD.
Recently, molecular emissions from the laser-induced plasma in ambient gas have gained increasing interest; however, very little is known about the case in water solutions. In this work, we investigated the spatiotemporal characteristics of molecular emissions, CaOH for instance, in underwater laser-induced breakdown spectroscopy (LIBS) by using time-resolved spectroscopy, spectral-resolved imaging, and shadowgraph techniques. It was shown that clear CaOH molecular bands can be observed in the spectrum at very early times after the laser pulse and presented a much longer lifetime and more homogeneous emission distribution compared with the Ca I and Ca II lines.
View Article and Find Full Text PDFThe arachidonic acid (AA) metabolizing enzymes are the potential therapeutic targets of cardiovascular diseases (CVDs). As sex differences have been shown in the risk and outcome of CVDs, we investigated the regulation of heart AA metabolizing enzymes (COXs, LOXs, and CYPs) by sex-dependent growth hormone (GH) secretory patterns. The pulsatile (masculine) GH secretion at a physiological concentration decreased CYP1A1 and CYP2J3 mRNA levels more efficiently in the H9c2 cells compared with the constant (feminine) GH secretion; however, CYP1B1 mRNA levels were higher following the pulsatile GH secretion.
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