Publications by authors named "Xuejian Dan"
Article Synopsis
- The study investigates the role of β-arrestin 1 (ARRB1) in intervertebral disc degeneration (IVDD), which is a major cause of lower back pain.
- Researchers found that ARRB1 expression increases in degenerated nucleus pulposus tissues and influences cell processes like apoptosis and autophagy.
- Overexpressing ARRB1 showed protective effects against IVDD by reducing cell death and extracellular matrix degradation, suggesting it could be a potential treatment strategy.
Neurogenic intermittent claudication (NIC), a classic symptom of lumbar spinal stenosis (LSS), is associated with neuronal apoptosis. To explore the novel therapeutic target of NIC treatment, we constructed the rat model of NIC by cauda equina compression (CEC) method and collected dorsal root ganglion (DRG) tissues, a region responsible for sensory and motor function, for mRNA sequencing. Bioinformatic analysis of mRNA sequencing indicated that upregulated metallothionein 2A (MT2A), an apoptosis-regulating gene belonging to the metallothionein family, might participate in NIC progression.
View Article and Find Full Text PDF