Publications by authors named "Xuehua Li"

Inflammatory bowel disease (IBD) is a recurrent bowel disease that usually requires magnetic resonance enterography (MRE) for diagnosis and monitoring. However, recognition of bowel segments from MRE images by a radiologist is challenging and time-consuming. Deep learning-based medical image segmentation has shown the potential to reduce manual effort and provide automated tools to assist in disease management; however, it requires a large-scale fine-annotated dataset for training.

View Article and Find Full Text PDF

The hormesis effect has gradually become a research focus in environmental science and toxicology due to its unique phenomenon of low-concentration stimulation and high-concentration inhibition. The combined toxicity of antibiotics and their regulatory effects on microorganisms are areas that warrant significant attention. In this study, doxycycline hydrochloride (DXC), sulfamethoxazole (SMX) and sulfamethazine (SMZ) were used as the research objects, and Scenedesmus obliquus was used as the indicator organism to study their toxicity and action laws at different exposure times (4d and 8d).

View Article and Find Full Text PDF

This study was to investigate the clinical significance of soluble B7-dendritic cell (sB7-DC) concentration in bronchoalveolar lavage fluid (BALF) of children with Refractory Mycoplasma pneumoniae pneumonia (RMPP). A total of 298 patients with Mycoplasma pneumoniae pneumonia (MPP) were enrolled. Patients were divided into general MPP (GMPP) (n = 213) and RMPP groups (n = 85).

View Article and Find Full Text PDF

The study aims to examine fluctuations in the levels of serum vitamin A, 25-(OH)D, TG2, IL-4, and IL-13 in pediatric eczema patients and explore how these changes relate to the severity of the condition. This retrospective study analyzed the clinical data of 159 children with eczema admitted to the hospital from May 2023 to October 2024 as the experimental group. The patients were divided into groups according to the severity of the disease: mild group(≤ 25 points, n = 45), moderate group(25-50 points, n = 72) and severe group(>50 points, n = 42).

View Article and Find Full Text PDF

Background: The detection and early identification of people living with HIV/AIDS (PLWH) and their rapid engagement in antiretroviral treatment are indispensable for fighting HIV transmission. This study aimed to elicit preferences regarding HIV testing among community residents to identify a model of community-based HIV testing services that would appeal to this population.

Methods: A discrete-choice experiment (DCE) was conducted in the communities of Yunnan Province, China.

View Article and Find Full Text PDF

Pillar stability has garnered significant attention owing to the effects of pillars on coal resource recovery rate, coal pillar stability, and coal bump risk. This study examined the roadway stability control principles of conventional and yield coal pillars. The conventional coal pillars were designed as load-bearing structures with a high load-bearing capacity to carry most of the abutment load, while yield coal pillars were designed as buffer structures for transferring rapidly increasing abutment loads to adjacent solid coal ribs by progressive deformation.

View Article and Find Full Text PDF

Background: The advancement of nanotechnology underscores the imperative need for establishing in silico predictive models to assess safety, particularly in the context of chronic respiratory afflictions such as lung fibrosis, a pathogenic transformation that is irreversible. While the compilation of predictive descriptors is pivotal for in silico model development, key features specifically tailored for predicting lung fibrosis remain elusive. This study aimed to uncover the essential predictive descriptors governing nanoparticle-induced pulmonary fibrosis.

View Article and Find Full Text PDF

The screening of novel antiviral agents from marine microorganisms is an important strategy for new drug development. Our previous study found that polyether K-41A and its analog K-41Am, derived from a marine Streptomyces strain, exhibit anti-HIV activity by suppressing the activities of HIV-1 reverse transcriptase (RT) and its integrase (IN). Among the K-41A derivatives, two disaccharide-bearing polyethers-K-41B and K-41Bm-were found to have potent anti-HIV-1 activity in vitro.

View Article and Find Full Text PDF

Objective: To conduct a comprehensive review of reversible factors associated with breast cancer, with the aim of offering insights for the creation of early intervention strategies for breast cancer prevention.

Methods: The PubMed, EMBASE, and Scopus databases were systematically searched to collect systematic reviews and meta-analyses related to breast cancer risk. Searches were limited to literature published from the inception of each database up to May 1, 2024.

View Article and Find Full Text PDF

Background: Acute pulmonary embolism (APE) is a critical disease with a high mortality rate, some of the surviving patients may develop chronic thromboembolic pulmonary disease (CTEPD), which affects the patient's prognosis. However, the research on the early diagnosis of CTEPD is limited. This study aimed to establish a prediction model for earlier identification of CTEPD.

View Article and Find Full Text PDF
Article Synopsis
  • Advances in nanotechnology have led to increased human exposure to metal oxide nanoparticles (MeONPs), which can cause immune toxicity, specifically affecting lung macrophages.
  • Machine learning (ML) methods were employed to create predictive models for MeONP toxicity, using a dataset of 240 data points related to their lethality and properties.
  • The best-performing ML model demonstrated high accuracy in predicting toxicity and identified key parameters impacting it, providing valuable insights for risk assessment and the safe design of nanoparticles.
View Article and Find Full Text PDF

While analyses are commonly employed for chemical risk assessments, predicting chronic lung toxicity induced by engineered nanoparticles (ENMs) still faces many challenges due to complex interactions at multiple nanobio interfaces. In this study, we developed a rigorous method to compile published evidence on the lung toxicity of metal oxide nanoparticles (MeONPs) and revealed previously overlooked -to- extrapolation (IVIVE) relationships. A comprehensive multidimensional data set containing 1102 data points, 75 pulmonary toxicological biomarkers, and 20 features (covering effects, physicochemical properties, and exposure conditions) was constructed.

View Article and Find Full Text PDF
Article Synopsis
  • A new dsRNA virus called "Valeriana jatamansi cryptic virus 1" (VJCV1) was found in Valeriana jatamansi plants showing symptoms in Yunnan, with its complete genome sequenced.
  • VJCV1 has two segments of dsRNA, which code for an RNA polymerase and a coat protein, and features unique structures typical of the Alphapartitivirus genus.
  • Phylogenetic analysis indicates that VJCV1 is distinct from other known viruses in the genus, suggesting it should be classified as a new species within Alphapartitivirus, marking the first virus from this group identified in Valeriana plants.
View Article and Find Full Text PDF

The fingerprint features of visceral adipose tissue (VAT) are intricately linked to bowel damage (BD) in patients with Crohn's disease (CD). We aimed to develop a VAT fingerprint index (VAT-FI) using radiomics and deep learning features extracted from computed tomography (CT) images of 1,135 CD patients across six hospitals (training cohort,  = 600; testing cohort,  = 535) for predicting BD, and to compare it with a subcutaneous adipose tissue (SAT)-FI. VAT-FI exhibited greater predictive accuracy than SAT-FI in both training (area under the receiver operating characteristic curve [AUC] = 0.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the gut-brain axis dysfunction as a factor in Crohn's disease (CD) and aims to create a brain MRI-based radiomics model to analyze neural changes in CD patients.
  • Using data from 230 CD patients and 46 healthy controls, researchers developed and validated a model that shows high accuracy in distinguishing CD patients from healthy individuals based on MRI features.
  • The findings suggest significant correlations between specific blood metabolites and microbiota in CD patients, indicating that dysbiosis may influence brain blood flow and contribute to the disease's pathology.
View Article and Find Full Text PDF

The poor timeliness of routing has always been an urgent problem in practical operator networks, especially in situations with large-scale networks and multiple network domains. In this article, a pruning idea of routing integrated with Dijkstra's shortest path searching is utilized to accelerate the process of routing in large-scale multi-domain elastic optical networks (EONs). The layered-graph approach is adopted in the spectrum allocation stage.

View Article and Find Full Text PDF

Antibiotics may be exposed in a mixed state in natural environments. The toxicity of antibiotic mixtures exhibits time-dependent characteristics, and data on the time-dependent toxicity of antibiotic mixtures is also relatively lacking. In this study, the toxicities of 45 binary mixtures composed of five antibiotics were investigated against sp.

View Article and Find Full Text PDF
Article Synopsis
  • IVIVE (In Vitro to In Vivo Extrapolation) is a key component in next-generation risk assessment that translates bioactive chemical concentrations from laboratory assays to real-world exposures using physiologically-based toxicokinetic models and machine learning algorithms.
  • * The review discusses the rapid growth of IVIVE research in the past five years, examining its origins, the efforts by national agencies to support its development, and analyzing recent publications and key research trends.
  • * It proposes future directions for IVIVE, including focusing on metabolite toxicity and vulnerable populations, as well as integrating advanced technologies like systems biology to improve toxicity predictions.
View Article and Find Full Text PDF

Management of giant complex thrombosed aneurysms of the middle cerebral artery (MCA) is challenging. Most giant MCA aneurysms possess some unfavorable features, such as incorporation of key MCA branches, efferent or perforating vessels originating from the sac, mural calcifications, intraluminal thrombi, or fusiform configurations. Due to these peculiar features, traditional clipping or simple endovascular coiling is generally not able to treat these aneurysms.

View Article and Find Full Text PDF

Mechanical loading is essential for bone growth and homeostasis, with osteocytes considered the primary mechanosensors. Deleting the mechanosensitive ion channel Piezo1 from Dmp1-Cre-targeted cells, which include both osteoblasts and osteocytes, resulted in reduced bone mass and impaired skeletal responses to mechanical stimuli. To specifically isolate Piezo1's role in osteocytes, we used Sost-Cre mice to generate mice with Piezo1 deletion exclusively in mature osteocytes.

View Article and Find Full Text PDF

Purpose: Lifelong re-examination of CT enterography (CTE) in patients with inflammatory bowel disease (IBD) may be necessary, and reducing radiation exposure during CT examinations is crucial. We investigated the potential application of deep learning reconstruction (DLR) in CTE to reduce radiation dose and improve image quality in IBD.

Methods: Thirty-six patients with known or suspected IBD were prospectively recruited to the low-dose CTE (LDCTE) group, while forty patients were retrospectively selected from previous clinical standard-dose CTE (STDCTE) scans as controls.

View Article and Find Full Text PDF

The limited number of organic micropollutants (OMPs) investigated in aquaculture seawater may underestimate the risk to marine organisms. It is critical to comprehensively investigate the occurrence of diverse OMPs in mariculture area and assess their joint risks to coastal marine organisms. Herein, the joint risks caused by multiple substances were assessed based on the screened results of approximately 1300 non-polar to polar OMPs in the seawater of mariculture ponds and raft culture areas around Liaodong Peninsula.

View Article and Find Full Text PDF

Intestinal fibrosis is the primary cause of disability in patients with Crohn's disease (CD), yet effective therapeutic strategies are currently lacking. Here, we report a multiomics analysis of gut microbiota and fecal/blood metabolites of 278 CD patients and 28 healthy controls, identifying characteristic alterations in gut microbiota (e.g.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionq437dfgrvjqejqb56cr586ak726uedk3): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once