Characterization and genomic analysis of a jumbo phage, PG216, with broad lytic activity against several Vibrio species.

In this study, a lytic phage, named PG216, was obtained from seawater collected in Qingdao, using Vibrio parahaemolyticus strain G299 as its host. Transmission electron microscopy revealed that phage PG216 has an icosahedral head with a diameter of 100 ± 6.7 nm and a contractible tail with a length of 126 ± 6.

Association between all-cause mortality and triglyceride glucose body mass index among critically ill patients with sepsis: a retrospective cohort investigation.

Background: We determined utilizing a sepsis participant cohort whether there is a significant association between TyG-BMI (triglyceride glucose body mass index) and mortality rates at any stage.

Methods: Herein, a historical cohort investigation approach was adopted, using information provided by the Medical Information Mart for Intensive Care-IV (MIMIC-IV). We categorized the included individuals in accordance with their TyG-BMI data quartiles, and the primary outcomes were mortality during the hospital stay and death rate due to any reason at postadmission day 28, 90, and 365.

[Two new phenolic glucosides with antioxidant activity from Lythrum salicaria].

Chromatographic techniques were employed to separate and purify the active components with antioxidant activity from the aboveground part of Lythrum salicaria. The data of 1D/2D NMR, optical rotation, and high-resolution mass spectrometry were used to identify the purified compounds. Six phenolic glucosides were identified, including 6'-(p-methoxyphenyl)gallate-7-O-β-D-glucopyranoside(1), 6'-ethyl-p-hydroxyphenylethanol-β-D-glucopyranoside(2), 3,4,5-trimethoxyphenol-β-D-glucopyranoside(3), 3,4,5-trimethoxyphenyl 1-O-β-apiofuranosyl(1″→6')-β-glucopyranoside(4), benzylalcohol O-α-L-arabinopyranosyl(1→6)-β-D-glucopyranoside(5), and 6'-acetylethanol-β-D-glucopyranoside(6).

Surface Roughening Behavior and Mechanism in Aluminum Alloy Under Tensile Deformation.

Surface roughening (SR) has been found to occur in solid solution 2219 aluminum alloy under tensile deformation, which will deteriorate its surface quality. To make a precise study of the surface roughening (SR) behavior and mechanism, the surface morphology of annealed and solid solution 2219 aluminum alloy was compared and crystal plasticity finite element (CPFE) simulation was carried out in this study. Thereinto, representative volume element (RVE) models of polycrystals were established according to the initial grain morphology measured by electron backscatter diffraction (EBSD).

Tegoprazan-Amoxicillin Dual Therapy for Helicobacter pylori Eradication: A Prospective, Randomized, Multicenter Study in Fujian, China.

Introduction: Few studies have investigated the efficacy and safety of tegoprazan-amoxicillin (TA) dual therapy for Helicobacter pylori eradication. We aim to evaluate the effectiveness and safety of different dosages of TA dual therapy for H. pylori eradication.

Enhancing mechanical and blocking properties of gelatin films using zein-quercetin nanoparticle and applications for strawberry preservation.

New gelatin films incorporated with zein-quercetin nanoparticles (GA/ZQNPs) were developed. The GA/ZQNP films had improved tensile strength, water vapor and oxygen barrier capabilities, hydrophobicity, UV blocking feature, antioxidant activities and antimicrobial properties, which varied with various contents of ZQNPs. Notably, the GA/ZQNP-10 films exhibited enhanced tensile stress value around 3.

Molecule level precise construction of donor-acceptor polymeric carbon nitride for photocatalytic hydrogen evolution.

Constructing donor-acceptor structures in polymeric carbon nitride (CN) provides an attractive pathway for facilitating charge carrier separation in photocatalytic reactions. However, achieving the implantation of donor or acceptor moieties at molecule level precision remains challenging. Here we develop a three-dimensional (3D) porous thiophene implanted carbon nitride (TCN) with donor-acceptor structure via a supramolecular assembly strategy.

CKIP-1 inhibits M2 macrophage polarization to suppress the progression of gastric cancer by inactivating JAK/STAT3 signaling.

Gastric cancer (GC) is a frequently occurring malignancy with poor prognosis. Casein kinase 2 interacting protein-1 (CKIP-1) is a PH domain-containing protein implicated in regulating tumorigenesis and macrophage homeostasis. This study aimed to elucidate the role and potential mechanism of CKIP-1 in the progression of GC.

A Novel Lactam and Two Rare Mycophenolic Acid Derivatives from the Fungus Penicillium Sclerotiorum JBHL321.

A novel lactam penicillactam (1), two rare mycophenolic acid (MPA) derivatives penimycophens A and B (2 and 3), together with two known biogenetically related MPA derivatives (4 and 5) and a known alkaloid (6) were isolated from the Penicillium sclerotiorum JBHL321. The structures of these compounds were determined by comprehensive spectroscopic analyses. The absolute configuration of 1 was confirmed by electronic circular dichroism (ECD) calculations.

Electron-proton relaxation in hot-dense plasmas with a screened quantum statistical potential.

Modeling the nonequilibrium process between ions and electrons is of great importance in laboratory fusion ignition, laser-plasma interaction, and astrophysics. For hot and dense plasmas, theoretical descriptions of Coulomb collisions remain complicated due to quantum effect at short distances and screening effect at long distances. In this paper, we propose an analytical screened quantum statistical potential that takes into account both the short-range quantum diffraction effect and the long-range screening effect.

Construction of quaternary alkyl motifs through palladium-catalyzed oxidative coupling of 1,3-dicarbonyl compounds with alkenes followed by C-C bond cleavage.

A palladium-catalyzed coupling reaction has been developed for the generation of tertiary alkylation products by reacting olefins with diversely functionalized 1,3-dicarbonyls. The reaction involves the tertiary C-H alkylation of 1,3-dicarbonyls with olefins to produce a tertiary alcohol, followed by C-C bond cleavage.

Real-world effectiveness of adjuvant octreotide therapy in patients with pancreatic neuroendocrine tumors at high recurrence risk: A multicenter retrospective cohort study.

Adjuvant therapy for pancreatic neuroendocrine tumors (PanNETs) after radical resection lacks evidence-based data and remains controversial. This study aimed to validate whether long-acting octreotide is a potential candidate for adjuvant therapy in patients with G2 PanNETs at high recurrence risk by clustering real-world data. A retrospective review of patients with nonmetastatic grade 2 PanNETs who underwent radical resection at six research centers between 2008 and 2020 was conducted.

phage HH109 uses capsular polysaccharide for infection of .

phage HH109 is a lytic E110-specific phage, but the molecular mechanism underlying host recognition of this phage remains unknown. In this study, a transposon mutagenesis library of E110 was used to show that several capsular polysaccharide (CPS) synthesis-related genes were linked to the phage HH109 infection. Gene deletion combined with multiple functional assays demonstrated that CPS serves as the receptor for the phage HH109.

The dark side of mental toughness: a meta-analysis of the relationship between the dark triad traits and mental toughness.

Introduction: This meta-analysis investigates the relationships between the Dark Triad personality traits (narcissism, Machiavellianism, and psychopathy) and mental toughness. Previous research has shown mixed results regarding the influence of these traits on mental toughness. The objective of this meta-analysis is to synthesize existing literature and provide a comprehensive understanding of how Dark Triad traits correlate with mental toughness.

CuBr-mediated dehydrogenative [4+2] annulation of 1-naphthyl-1,3-indandiones and alkenes.

Intermolecular annulation reactions of 1-naphthyl-1,3-indandiones with alkenes proceed efficiently in the presence of a copper catalyst to generate spirocarbocycle compounds. Various spirocyclic molecules bearing an all-carbon quaternary center could be obtained by this novel method with good yields, excellent regioselectivity, and good functional group tolerance. A radical mechanism is proposed based on the HRMS analysis results of control experiments.

Direct access to furan and cyclopropane derivatives palladium-catalyzed C-H activation/alkene insertion/annulation.

A practical and effective palladium-catalyzed C-H activation/alkene insertion/annulation has been reported for the synthesis of furans and cyclopropanes from cyclic 1,3-diketones or 1,3-indandione and diverse alkenes, resulting in moderate to good yields. This protocol demonstrates excellent selectivity and is well-compatible with a wide range of alkene substrates, exhibiting exceptional regioselectivities, high efficiency, and good functional group tolerance.

Study on the Impact Failure Rules of Roadway Floor Induced by Dynamic Load Disturbance under Extremely Thick Conglomerate.

The dynamic load resulting from the fracture of extremely thick rock layers directly influences the surrounding rock layers within stopes and roadways, thereby inducing rockburst disasters. Hence, studying the tunnel floor's impact and ground pressure induced by dynamic load disturbance under extremely thick conglomerates is crucial. This study focuses on the 23130 working face of Yuejin Coal Mine as its engineering background.

Mindfulness Meditation Training Reduces Gaming Cravings by Reshaping the Functional Connectivity Between the Default Mode Network and Executive Control-Related Brain Regions.

Background: Internet gaming disorder (IGD) can lead to psychological problems and cause behavioral problems in individuals. Traditional interventions have been ineffective in treating IGD. Meanwhile, mindfulness meditation (MM) is an emerging method that has proven to be effective for treating psychiatric disorders.

Integration of multiomics analyses reveals unique insights into CD24-mediated immunosuppressive tumor microenvironment of breast cancer.

Background: Tumor immunotherapy brings new light and vitality to breast cancer patients, but low response rate and limitations of therapeutic targets become major obstacles to its clinical application. Recent studies have shown that CD24 is involved in an important process of tumor immune regulation in breast cancer and is a promising target for immunotherapy.

Methods: In this study, singleR was used to annotate each cell subpopulation after t-distributed stochastic neighbor embedding (t-SNE) methods.

Multi-Mode Damage and Fracture Mechanisms of Thin-Walled Tubular Parts with Cross Inner Ribs Manufactured via Flow Forming.

In order to study the multi-mode damage and fracture mechanisms of thin-walled tubular parts with cross inner ribs (longitudinal and transverse inner ribs, LTIRs), the Gurson-Tvergaard-Needleman (GTN) model was modified with a newly proposed stress state function. Thus, tension damage and shear damage were unified by the new stress state function, which was asymmetric with respect to stress triaxiality. Tension damage dominated the modification, which coupled with the shear damage variable, ensured the optimal prediction of fractures of thin-walled tubular parts with LTIRs by the modified GTN model.

Mitogen-activated protein kinase MxMPK3-2 mediated phosphorylation of MxZR3.1 participates in regulating iron homoeostasis in apple rootstocks.

The micronutrient iron plays a crucial role in the growth and development of plants, necessitating meticulous regulation for its absorption by plants. Prior research has demonstrated that the transcription factor MxZR3.1 restricts iron absorption in apple rootstocks; however, the precise mechanism by which MxZR3.

Three new indole alkaloid derivatives from Fissistigma oldhamii Levl. and their anti-inflammatory effects.

Three new indole alkaloid derivatives, fissindoalkas A-C (1-3) together with one known biogenetically related polysubstituted indole alkaloid (4) were isolated from the roots of Fissistigma oldhamii (Hemsl.) Merr. The structures of compounds 1-4 were elucidated using comprehensive spectroscopic methods.