[Comparison of anterior lateral ligament reconstruction and anterior lateral complex repair in the treatment of anterior cruciate ligament combined with anterior lateral ligament injury with high-grade pivot shift].

Objective: To retrospectively analyze the clinical efficacy of anterior cruciate ligament (ACL) reconstruction combined with anterolateral complex repair and ACL reconstruction combined with ALL reconstruction in the treatment of anterior cruciate ligament injuries with high-grade pivot shift.

Methods: From January 2018 to June 2022, 49 patients combined ACL and ALL injuries with high-grade pivot shift were retrospectively studied from three hospitals, 29 of them underwent ACL reconstruction with anterolateral complex repair (repair group), including 23 males and 6 females with an average age of (27.5±4.

The impact of the heterogeneity of market participants on China's green certificate trading: A collective action perspective.

Renewable portfolio standards (RPS) and tradable green certificate (TGC) systems are mandatory institutional change that promote the renewable energy development and improve the environment in China. Their implementation will cause collective action issues among market entities. Collective action of participating in TGC trading is crucial for transaction success and the effectiveness of system implementation.

Developing a Scale for Measuring the Fundamental Movement Skills of Preschool Children in China.

Children aged 3-6 years (preschool children hereafter) are in a critical and sensitive period of developing fundamental movement skills (FMS). While appropriate measurement tools can accurately evaluate their FMS development, such a scale is lacking in China. In this study, a suitable scale for measuring the FMS of preschool children in China was developed by combining process- and results-oriented evaluation methods.

One-step efficient generation of dual-function conditional knockout and geno-tagging alleles in zebrafish.

CRISPR/Cas systems are widely used to knock out genes by inducing indel mutations, which are prone to genetic compensation. Complex genome modifications such as knockin (KI) might bypass compensation, though difficult to practice due to low efficiency. Moreover, no 'two-in-one' KI strategy combining conditional knockout (CKO) with fluorescent gene-labeling or further allele-labeling has been reported.

N,O-Bidentate ligand-tunable copper(ii) complexes as a catalyst for Chan-Lam coupling reactions of arylboronic acids with 1H-imidazole derivatives.

An efficient procedure for Chan-Lam coupling reactions of arylboronic acids with 1H-imidazole derivatives using N,O-bidentate ligand-tunable copper(ii) complexes as a catalyst under base-free conditions has been developed. This protocol features mild reaction conditions, high yields and compatibility with different functional groups, providing a direct and facile strategy for the construction of C-N bonds and synthesis of heterocyclic compounds.

[Naoluoxintong reduces protein expression of TLR4, TRAF6 and TNF-α in frontal and parietal cortex of rats with focal cerebral ischemia reperfusion].

Objective To investigate the effect of Naoluoxintong on the protein expression of Toll like receptor 4 (TLR4), tumor necrosis factor receptor associated factor-6 (TRAF6) and tumor necrosis factor-α (TNF-α) in the frontal and parietal cortex of the rats with middle cerebral artery occlusion and reperfusion (MCAO/R). Methods The modified rat model of MCAO/R was established by suture method. SD rats were randomly divided into four groups: a sham control group, a model group, a Tongxinluo group, and a Naoluoxintong group, with 30 rats in each group.

Fast Swept-Wavelength, Low Threshold-Current, Continuous-Wave External Cavity Quantum Cascade Laser.

We present a low threshold-current and fast wavelength-tuning external cavity quantum cascade laser (EC-QCL) using a scanning galvanometer in the Littman-Metcalf cavity geometry. The EC-QCL could repeatedly swept at 100 Hz over its full tuning range of about 290 nm (2105 cm to 2240 cm), providing a scan rate of 59.3 μm s.

Wnt signaling pathway upregulates DNMT1 to trigger NHERF1 promoter hypermethylation in colon cancer.

NHERF1 is downregulated and has been identified as a new marker of colorectal cancer. However, the molecular mechanism of NHERF1 downregulation in colon cancer is not well understood. In the present study, we demonstrated that the NHERF1 mRNA level was downregulated and correlated with outcomes in colon cancer patients.

[Clinical observation on the effect of joint mobilization in treating elderly patients after distal radius fractures operation].

Objective: To investigate the effect of joint mobilization on postoperative wrist joint function, pain and grip strength for elderly patients with distal radius fracture.

Methods: From January 2015 to June 2016, a total of 67 elderly patients with distal radius fracture were randomly divided into routine exercise group and joint mobilization group. Among them, 37 patients in the routine exercise group underwent conventional distal radius fracture postoperative joint function exercise regimen, including 16 males and 21 females with a mean age of (67.

Chaetospirolactone reverses the apoptotic resistance towards TRAIL in pancreatic cancer.

The pancreatic cancer is one of the most aggressive tumors. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can trigger apoptosis by interaction with death receptors. However, in TRAIL-resistant pancreatic cancer, responsiveness to TRAIL treatment is terribly poor.

HOX transcript antisense intergenic RNA represses E-cadherin expression by binding to EZH2 in gastric cancer.

Aim: To clarify the mechanisms of HOX transcript antisense intergenic RNA (HOTAIR) in gastric cancer (GC) migration and invasion.

Methods: Quantitative real-time polymerase chain reaction (qPCR) was used to detect the expression level of HOTAIR in GC tissues. The correlation of its expression with clinicopathological features was analyzed.

Tigecycline targets nonsmall cell lung cancer through inhibition of mitochondrial function.

Nonsmall cell lung cancer (NSCLC) is the most common type of lung cancer with a high mortality rate and still remains therapeutically a challenge. A strategy to target NSCLC is to identify agents that are effective against NSCLC cells while sparing normal cells. We show that tigecycline, an FDA-approved antibiotic drug, preferentially targets NSCLC cells.

Rhodium-catalyzed ortho-cyanation of symmetrical azobenzenes with N-cyano-N-phenyl-p-toluenesulfonamide.

A rhodium-catalyzed ortho-cyanation of symmetrical azobenzenes is described employing N-cyano-N-phenyl-p-toluenesulfonamide as an environmentally friendly cyanide source. The present protocol allows the synthesis of various benzonitrile derivatives in moderate to good yields and tolerates many useful functional groups.

Rhodium-catalyzed direct C-H amidation of azobenzenes with sulfonyl azides: a synthetic route to sterically hindered ortho-substituted aromatic azo compounds.

A rhodium(III)-catalyzed direct ortho-amidation of azobenzenes with sulfonyl azides as the amino source is disclosed. This reaction exhibits a broad substrate scope, high functional group tolerance, and regioselectivity, providing a variety of sterically hindered ortho-substituted azobenzene derivatives in good to excellent yield.

Enhanced brain targeting of curcumin by intranasal administration of a thermosensitive poloxamer hydrogel.

Objectives: The aim of this study was to develop a curcumin intranasal thermosensitive hydrogel and to improve its brain targeting efficiency.

Methods: The hydrogel gelation temperature, gelation time, drug release and mucociliary toxicity characteristics as well as the nose-to-brain transport in the rat model were evaluated.

Key Findings: The developed nasal hydrogel, composed of Pluronic F127 and Poloxamer 188, had shorter gelation time, longer mucociliary transport time and produced prolonged curcumin retention in the rat nasal cavity at body temperature.

Functionalized graphene oxide mediated adriamycin delivery and miR-21 gene silencing to overcome tumor multidrug resistance in vitro.

Multidrug resistance (MDR) is a major impediment to successful cancer chemotherapy. Co-delivery of novel MDR-reversing agents and anticancer drugs to cancer cells holds great promise for cancer treatment. MicroRNA-21 (miR-21) overexpression is associated with the development and progression of MDR in breast cancer, and it is emerging as a novel and promising MDR-reversing target.

Catalytic enantioselective aryl transfer to aldehydes using chiral 2,2'-bispyrrolidine-based salan ligands.

Chiral C₂-symmetric diamines have emerged as versatile auxiliaries or ligands in numerous asymmetric transformations. Chiral 2,2'-bispyrrolidine-based salan ligands were prepared and applied to the asymmetric aryl transfer to aldehydes with arylboronic acids as the source of transferable aryl groups. The corresponding diarylmethanols were obtained in high yields with moderate to good enantioselectivitives of up to 83% ee.

[Application of tissue flaps in repair of limbs injuries].

Objective: To summarize and analyze the main point on the reconstruction of traumatic tissue defects of limbs with vascularized skin and multi-tissue flaps.

Methods: Sixty-seven cases of traumatic tissue defects of limbs were reconstructed with 14 kinds of skin or multi-tissue flaps. The operative methods included local transposition, cross-transposition with vessel pedicles and vessel anastomosed free transplantation.