Publications by authors named "Xuefeng Guang"
Purpose: Necroptosis, a monitored form of inflammatory cell death, contributes to coronary heart disease (CHD) progression. This study examined the potential of using necroptosis genes as diagnostic markers for CHD and sought to elucidate the underlying roles.
Methods: Through bioinformatic analysis of GSE20680 and GSE20681, we first identified the differentially expressed genes (DEGs) related to necroptosis in CHD.
Background: Computed tomography (CT) image integration is of limited use in left ventricular (LV) ablation due to inadequate accuracy of registration. The current study aimed to investigate the accuracy and feasibility of extra-cavity LV image registration via the coronary cusp.
Methods: Consecutive patients were enrolled as the validation group (n = 41) and feasibility group (n = 48).
Restrictive cardiomyopathy (RCM) is a rare childhood cardiomyopathy that is a challenging diagnostic problem for clinicians. We describe a case of an 8-year-old girl with a 2-year history of shortness of breath on exertion. Electrocardiogram and echocardiography showed biatrial enlargement, while cardiac magnetic resonance showed biatrial dilation and normal pericardial thickness.
View Article and Find Full Text PDFCoronary artery disease (CAD) is one of leading causes of mortality worldwide. Studies on roles that the gut microbiota plays in development of atherosclerosis or acute myocardial infarction (AMI) have been widely reported. However, the gut microbiota is affected by many factors, including age, body mass index (BMI), and hypertension, that lead to high CAD risk.
View Article and Find Full Text PDFKartagener's syndrome is a subgroup of primary ciliary dyskinesia (PCD), a genetically heterogeneous condition characterised by sinusitis, bronchiectasis, and situs in versus. Genetic testing has importance for their diagnosis. Here, we report a chinese patient with Kartagener's syndrome.
View Article and Find Full Text PDFBackground: Health care quality and insurance coverage have improved with economic development in China, but the burden of cardiovascular diseases (CVDs) continues to increase with ongoing gaps in prevention. We aimed to compare the uptake of secondary CVD prevention between stroke and coronary heart disease (CHD) patients in China.
Methods: In a cross-sectional community-based survey of 47,841 adults (age ≥45 years) in 7 regions of China between 2014 and 2016, we identified those with a history of stroke or CHD to quantify disparities in conventional secondary CVD prevention strategies in multivariable logistic regression models.
Objectives: There is an increasing trend of skipping meals, especially breakfast and dinner, in China. Previous studies on the association of meal skipping with lipid profiles and blood glucose have yielded inconsistent results.
Methods: A national representative survey of 47 841 adults (age ≥ 45 y) was conducted in China.
Article Synopsis
- A study in China analyzed the prevalence of depression and anxiety symptoms in patients with cardiovascular disease (CVD) using data from over 47,000 participants collected between 2014 and 2016.
- The findings revealed a prevalence of 2.9% for depression and 1.5% for anxiety among the general CVD population, with significantly higher rates observed in women with heart failure and stroke.
- The study highlights the need for mental health screening especially in high-risk groups, such as younger, unmarried females with lower incomes and a history of certain heart conditions.
Objective: To determine AF prevalence and gaps in atrial fibrillation (AF) awareness and management in China.
Methods: We conducted a community-based survey of 47 841 adults (age ≥45 years) in seven geographic regions of China between 2014 and 2016. Participants underwent a structured questionnaire, a standard 12-lead ECG, physical examination and blood sampling.
Hypoxia-induced apoptosis is linked to the pathogenesis of myocardial infarction (MI) and heart failure. Ubiquitin-specific peptidase 7 (USP7) is related to catabolic/pro-apoptotic signaling. However, its role in cardiomyocyte injury is unclear.
View Article and Find Full Text PDFTranscatheter closure of a huge pulmonary arteriovenous fistula.
Rev Esp Cardiol (Engl Ed)
September 2020
Background: Despite improvements in diagnostic and therapeutic interventions to combat cardiovascular disease (CVD) in recent decades, there are significant ongoing access gaps and sex disparities in prevention that have not been adequately quantified in China.
Methods: A representative, cross-sectional, community-based survey of adults (aged ≥45 years) was conducted in 7 geographic regions of China between 2014 and 2016. Logistic regression models were used to determine sex differences in primary and secondary CVD prevention, and any interaction by age, education level, and area of residence.
Article Synopsis
- - The study aimed to understand how common congenital heart disease (CHD) is among children in Yunnan, China, considering its varied ethnic groups.
- - Out of 244,023 children examined between 2010 and 2015, 1,695 were diagnosed with CHD, leading to a prevalence rate of 6.94%, with atrial septal defects being the most frequent type.
- - Factors like preterm birth, low birth weight, older maternal age, and living in high-altitude areas were linked to higher CHD rates, and the findings indicated ethnic variations in prevalence.
An rs13293512 polymorphism in the promoter of let-7 is associated with a reduced risk of ischemic stroke.
J Thromb Thrombolysis
November 2016
The expression of let-7 family members was differentiated in ischemic stroke (IS), functioning as an important regulating molecular in the pathophysiology of stroke. We hypothesized that genetic polymorphism in the promoters of let-7 family may be associated with the risk of IS. To test this hypothesis, we investigated the association of the rs10877887 and rs13293512 in the promoters of let-7 family with the susceptibility to IS.
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