Immunomodulatory Effects of Modified Colostrum, Whey, and Their Combination With Other Natural Products: Effects on Natural Killer Cells.

Objectives: Natural killer (NK) cells are important immune system effector cells providing innate defenses against intracellular infections, including viral infections, immune surveillance, and cancer immunoediting. The primary purpose of this study was to investigate whether modified ultra-filtrated colostrum (UC) and hydrolyzed whey (W) products or their combinations with other natural products with reported immunomodulatory properties will stimulate NK cell cytotoxic activity by activation of granzyme B and IFN-γ production.

Methods: The ability of study products to stimulate the cytotoxic activity of human-purified CD56 NK cells and the production of granzyme B and IFN-γ by activated NK cells was evaluated in the cytotoxic assay.

Promoted Electronic Coupling of Acoustic Phonon Modes in Doped Semimetallic MoTe.

As a prototype of the Weyl superconductor, layered molybdenum ditelluride (MoTe) encompasses two semimetallic phases (1T' and T) which differentiate from each other via a slight tilting of the out-of-plane lattice. Both phases are subjected to serious phase mixing, which complicates the analysis of its origin of superconductivity. Herein, we explore the electron-phonon coupling (EPC) of the monolayer semimetallic MoTe, without phase ambiguity under this thickness limit.

Surface asymmetry induced turn-overed lifetime of acoustic phonons in monolayer MoSSe.

Recent successful growth of asymmetric transition metal dichalcogenides via accurate manipulation of different chalcogen atoms in top and bottom surfaces demonstrates exotic electronic and chemical properties in such Janus systems. Within the framework of density functional perturbation theory, anharmonic phonon properties of monolayer Janus MoSSe sheet are explored. By considering three-phonons scattering, out-of-plane flexural acoustic (ZA) mode tends to undergo a stronger phonon scattering than transverse acoustic (TA) mode and the longitudinal acoustic (LA) mode with phonon lifetime of ZA (1.

A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacology.

Patient-derived tumor xenograft (PDX)/organoid (PDO), driven by cancer stem cells (CSC), are considered the most predictive models for translational oncology. Large PDX collections reflective of patient populations have been created and used extensively to test various investigational therapies, including population-trials as surrogate subjects in vivo. PDOs are recognized as in vitro surrogates for patients amenable for high-throughput screening (HTS).

Strong reduction of thermal conductivity of WSewith introduction of atomic defects.

The thermal conductivities of pristine and defective single-layer tungsten diselenide (WSe) are investigated by using equilibrium molecular dynamics method. The thermal conductivity of WSeincreases dramatically with size below a characteristic of ~5 nm and levels off for broader samples and reaches a constant value of ~2 W/mK. By introducing atomic vacancies, we discovered that the thermal conductivity of WSeis significantly reduced.

Electronic and optical properties of Janus black arsenic-phosphorus AsP quantum dots under magnetic field.

By utilizing the tight-binding method, the electronic spectrum and states distribution of square Janus monolayer black arsenic phosphorus (b-AsP) quantum dots (QDs) in the presence of a perpendicular magnetic field are explored. Strong in-gap states of b-AsP QDs, whose probability densities are distributed on the armchair boundary (armchair edge states) appear in the energy gap of host perfect two-dimensional b-AsP. The corresponding energy levels of the armchair edge states can degenerate to the Landu energy levels upon applying a perpendicular magnetic field.

Multifactor effects on the NO emissions and yield of potato fields based on the DNDC model.

Maintaining or increasing grain yields while also reducing the emissions of field agricultural greenhouse gases is an important objective. To explore the multifactor effects of nitrogen fertilizer on nitrous oxide (NO) emissions and the yield of potato fields and to verify the applicability of the denitrification-decomposition (DNDC) model when used to project the NO emission load and yield, this research chooses a potato field in Shenyang northeast China from 2017 to 2019 as the experiment site. The experiment includes four nitrogen levels observing the emission of NO by static chamber/gas chromatograph techniques.

Quantitative and qualitative analyses of orthodontic-related videos on YouTube.

Objectives: To investigate content of orthodontic-related videos on YouTube to improve the understanding of orthodontic patients' perceptions and treatment experiences.

Materials And Methods: A systematic search was conducted on YouTube on March 20, 2018, and updated on August 4, 2019, to identify all relevant videos using search terms "orthodontic," "orthodontics," "braces," and "orthodontic braces." The data set was captured from YouTube Data API (Application Programming Interface) and stored in an Excel database using a query function written in Python.

Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44.

As part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Li et al., 2015), that described how we intended to replicate selected experiments from the paper 'The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44' (Liu et al., 2011).

The Smaller the Leaf Is, the Faster the Leaf Water Loses in a Temperate Forest.

Leaf size (i.e., leaf surface area and leaf dry mass) profoundly affects a variety of biological carbon, water and energy processes.

Gambogic acid grafted low molecular weight heparin micelles for targeted treatment in a hepatocellular carcinoma model with an enhanced anti-angiogenesis effect.

Gambogic acid (GA) is a potential anti-cancer agent with poor water-solubility, whereas heparin has anti-angiogenesis effects with good hydrophilicity. In this study, GA grafted low molecular weight heparin (GA-LMWH) was prepared and self-assembled into micelles in aqueous solution to improve the solubility and antitumor effects against hepatocellular carcinoma. The substitution of GA-LMWH is 27.

[Seed flows of restoration succession series communities in alkaline meadow of Northeast China Songnen Plain].

After compared the source seed bank, soil seed bank, and seedling bank of the dominant species in four communities of restoration succession series in alkaline meadow of Songnen Plain, the model of seed flows was established. At early succession stage, the density of dominant source seed bank in Choris virgata community arrived its maximal value 446,182 +/- 180,455 seeds x m(-2) being 7.2 times of that in Puccinellia tenuiflora community at intermediate succession stage, 11.