Synthesis of 1,2-diselenides potassium persulfate-mediated diselenation of allenamides with diselenides.

An efficient potassium persulfate-mediated radical addition of allenamides with diselenides was developed to create a workable route to 1,2-diselenide products. The reaction tolerates a wide spectrum of functional groups to deliver the products in good to excellent yields. Mechanistic investigations including a calculation study indicated that the radical cascade proceeds through a vinyl radical intermediate, which is formed a selenium radical added to the terminal CC double bond of allenamides.