Efflux pump inhibitor combined with ofloxacin decreases MRSA biofilm formation by regulating the gene expression of NorA and quorum sensing.

Carbonyl cyanide -nitrophenylhydrazone (2e) displayed a lone or synergistic efficacy against MRSA (, 2020, 10, 17854). In this work, the synergistic mechanism of 2e with ofloxacin was studied. MRSA2858 had potential for biofilm formation, and the value of MBEC of 2e alone was 0.

Novel benzothiazole‒urea hybrids: Design, synthesis and biological activity as potent anti-bacterial agents against MRSA.

Novel benzothiazole‒urea hybrids were designed, synthesized and evaluated their anti-bacterial activity. They only exhibited anti-bacterial activity against Gram-positive bacteria, including clinical methicillin-resistant S. aureus (MRSA), compounds 5f, 5i, 8e, 8k and 8l exhibited potent activity (MIC = 0.

Novel FabI inhibitor disrupts the biofilm formation of MRSA through down-regulating the expression of quorum-sensing regulatory genes.

Objectives: The aim of this study was to explore the antibiofilm and antivirulence efficacy of benzylaniline 4k against MRSA.

Methods: The clinical MRSA strains were identified and used to evaluate their potential to form biofilm using crystal violet assay. The minimal inhibitory concentration (MIC) was determined using broth microdilution method.

Understanding risk perception from floods: a case study from China.

Understanding and improving the public risk perception have become an important element in the management of flood risk. In China, the risk government is of so-called nationwide catastrophe response mode which is different from the widely adopted "bottom up" risk governance mode in the Western countries. Such a particular mode may make Chinese people perceive risk in a different way from people in other countries.

Effect of new carbonyl cyanide aromatic hydrazones on biofilm inhibition against methicillin resistant .

Carbonyl cyanide -chlorophenylhydrazone (CCCP), as a protonophore, in combination with antibiotics exhibited potentiating antibacterial activity. To improve CCCP's potency and toxicity, a series of aromatic hydrazones were synthesized and their antimicrobial activity was evaluated; amongst them, compounds 2e and 2j with a strong -electron-withdrawing substituent (-NO and -CF) at the phenyl ring had the lowest MICs against both and methicillin resistant (1.56 and 1.