Fluorescent Polymer Nanocomposites as Novel Drug-Loading and Targeted Delivery Nanocarriers for Glioma Therapy by Modulating ERBB4.

Gliomas are the most common type of tumor in the human central nervous system, characterized by high aggressiveness, elevated mortality, and poor prognosis. Therefore, developing new therapeutic strategies is crucial for improving glioma treatment. Temozolomide (TMZ) is widely used in glioma therapy due to its excellent ability to penetrate the blood-brain barrier.

Intraoperative rapid molecular diagnosis aids glioma subtyping and guides precise surgical resection.

Objective: The molecular era of glioma diagnosis and treatment has arrived, and a single rapid histopathology is no longer sufficient for surgery. This study sought to present an automatic integrated gene detection system (AIGS), which enables rapid intraoperative detection of IDH/TERTp mutations.

Methods: A total of 78 patients with gliomas were included in this study.

The first prospective application of AIGS real-time fluorescence PCR in precise diagnosis and treatment of meningioma: Case report.

Background: The emergence of the new WHO classification standard in 2021 incorporated molecular characteristics into the diagnosis system for meningiomas, making the diagnosis and treatment of meningiomas enter the molecular era.

Recent Findings: At present, there are still some problems in the clinical molecular detection of meningioma, such as low attention, excessive detection, and a long cycle. In order to solve these clinical problems, we realized the intraoperative molecular diagnosis of meningioma by combining real-time fluorescence PCR and AIGS, which is also the first known product applied to the intraoperative molecular diagnosis of meningioma.

Application of Intraoperative Rapid Molecular Diagnosis in Precision Surgery for Glioma: Mimic the World Health Organization CNS5 Integrated Diagnosis.

Background: With the advent of the molecular era, the diagnosis and treatment systems of glioma have also changed. A single histological type cannot be used for prognosis grade. Only by combining molecular diagnosis can precision medicine be realized.

Intracavity generation of glioma stem cell-specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy.

Glioblastoma multiforme (GBM) remains incurable despite aggressive implementation of multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a narrow margin around the initial resected lesion due to postsurgery residual glioma stem cells (GSCs). Tracking and eradicating postsurgery residual GSCs is critical for preventing postoperative relapse of this devastating disease, yet effective strategies remain elusive.

The First Case Report of a Patient With Oligodendroglioma Harboring Germline Mutation.

(Checkpoint kinase 2) germline mutations were associated with an elevated risk of breast cancer, colorectal cancer, and other familiar cancers. Loss-of-function variants in are known to be pathogenic. Germline mutations have also been observed in medulloblastoma and primary glioblastomas.

Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFβ Axis.

Unlabelled: Macrophages perform key and distinct functions in maintaining tissue homeostasis by finely tuning their activation state. Within the tumor microenvironment, macrophages are reshaped to drive tumor progression. Here we report that tumor necrosis factor α-induced protein 8-like 1 (TIPE1) is highly expressed in macrophages and that depletion of TIPE1 impedes alternative activation of macrophages.

Multiregional viscoelastic properties of the porcine brain in the horizontal plane.

Comparison between the corpus callosum and different regions of corona radiata in the horizontal plane was tested in the article. A series of flat-punch indentation experiments were conducted on the corpus callosum and different regions of corona radiata with different loading rates on the porcine brain. A linear viscoelastic model with prony series approximation was fitted to the force-time data of all regions.

Genistein inhibits human papillary thyroid cancer cell detachment, invasion and metastasis.

Papillary thyroid carcinoma (PTC) is the most commonly diagnosed endocrine cancer, and those with mutation have high recurrence rate and less favorable clinical behavior. Genistein having anti-carcinoma effects in various types of carcinomas as an estrogen analog, but the mechanism of Genistein in the progression of PTC remains unknown. Genistein significantly inhibits the proliferation and the invasion (P < 0.

Multiregional viscoelastic characterization of the corona radiata in the sagittal plane of the porcine brain.

Detailed finite element (FE) models are used as promising tools to investigate traumatic brain injuries, although their accuracy is strongly dependent on the characterization of the mechanical behaviors of the different anatomic structures in the brain. In some cases, when the FE models require finer spatial resolution, the heterogeneous and anisotropic corona radiata cannot be taken as a homogeneous whole body. In this work, indentation experiments were conducted on the anterior, superior, and posterior regions of the corona radiata in the sagittal plane.

Decreased Siglec-9 Expression on Natural Killer Cell Subset Associated With Persistent HBV Replication.

Siglec-9 is an MHC-independent inhibitory receptor selectively expressed on CD56 NK cells. Its role in infection diseases has not been investigated yet. Here, we studied the potential regulatory roles of NK Siglec-9 in the pathogenesis of chronic hepatitis B (CHB) infection.

Tim-3 expression predicts the abnormal innate immune status and poor prognosis of glioma patients.

Malignant glioma, the most common and devastating primary brain tumor, has serious effects on human health with high risk of recurrence and short survival periods. Recently, the exploitation of immunological mechanisms shed new lights for developing novel therapeutic strategies for glioma pathogenesis. Tim-3, a member of T cell immunoglobulin and mucin domain family, has been involved in multiple diseases, including tumor, by regulating the viability and function of immunocytes.

Hepatitis B core protein promotes liver cancer metastasis through miR-382-5p/DLC-1 axis.

The hepatitis B virus core protein (HBc), also named core antigen, is well-known for its key role in viral capsid formation and virus replication. Recently, studies showed that HBc has the potential to control cell biology activity by regulating host gene expression. Here, we utilized miRNA microarray to identify 24 upregulated miRNAs and 21 downregulated miRNAs in HBc-expressed HCC cells, which were involved in multiple biological processes, including cell motility.

Elastic and viscoelastic mechanical properties of brain tissues on the implanting trajectory of sub-thalamic nucleus stimulation.

Corresponding to pre-puncture and post-puncture insertion, elastic and viscoelastic mechanical properties of brain tissues on the implanting trajectory of sub-thalamic nucleus stimulation are investigated, respectively. Elastic mechanical properties in pre-puncture are investigated through pre-puncture needle insertion experiments using whole porcine brains. A linear polynomial and a second order polynomial are fitted to the average insertion force in pre-puncture.

Intrasellar and Suprasellar Schwannoma Misdiagnosed as Pituitary Macroadenoma: A Case Report and Review of the Literature.

Background: Intracranial schwannomas usually arise from sensory nerves with a predilection for the trigeminal nerve and the vestibular component of the eighth cranial nerve (VIII). Schwannoma arising in the sella and extending into the suprasellar region is exceedingly rare and easily misdiagnosed as pituitary macroadenoma. Only 26 cases of intrasellar schwannomas have been reported in the literature.

The Impact of Initial Systemic Inflammatory Response After Aneurysmal Subarachnoid Hemorrhage.

Aim: To assess the association between inflammatory response and early brain injury (EBI), and the association between inflammatory response and the following pneumonia after aneurysmal subarachnoid hemorrhage (SAH).

Material And Methods: Eighty-nine patients with spontaneous SAH and 12 patients with unruptured aneurysm were included in this prospective study. The systemic inflammatory biomarkers such as C-reactive protein (CRP), IL-1?, IL-2,IL-6,IL-8, IL10 and T leukocyte subsets were measured within 24 hours after admission.

Endoscopic Endonasal Transsphenoidal Approach for Apoplectic Pituitary Tumor: Surgical Outcomes and Complications in 45 Patients.

Objective To assess the safety and effectiveness of the endoscopic endonasal transsphenoidal approach (EETA) for apoplectic pituitary adenoma. Design A retrospective study. Setting Qilu Hospital of Shandong University; Brain Science Research Institute, Shandong University.

CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.

CUL4A, a member of the CULLIN family, functions as a scaffold protein for an E3 ubiquitin ligase. It was reported that the CUL4A gene showed amplification in some human primary hepatocellular carcinomas (HCC). However, the exact role of CUL4A in HCC remains unknown.

Endonasal Endoscopic Transsphenoidal Approach to Lesions of the Sellar Region in Pediatric Patients.

Objective: Endoscopic endonasal (transnasal) transsphenoidal approach (EETA) for management of sellar lesions has gained popularity as a reliable and atraumatic method. Most reported studies of EETA have focused on surgical outcome in adult patients; and there are few reports to describe outcome in pediatric patients. The authors report our early experience of 11 patients aged 14 to 18 years managed with EETA to evaluate the safety and effectiveness of EETA in the pediatric.

Embolization of cavernous sinus dural arteriovenous fistula via inferior petrosal sinus: anatomical basis and management practicability.

The aim of this study is to explore anatomical basis and reevaluate the practicability of embolization of cavernous sinus dural arteriovenous fistulas (CSdAVFs) via the inferior petrosal sinus (IPS) with detachable coils and Onyx-18. In this study, retrospective studies were performed on 15 consecutive patients with CSdAVFs via the IPS treated by Onyx-18 and detachable coils in Qilu hospital between March 2009 and January 2013. One patient was treated with Onyx-18 only and others were treated by Onyx-18 combined with coils.

Fracture healing with osteopathy in traditional Mongolian medicine.

Objective: To explore the concept and norm of fracture healing with osteopathy in traditional Mongolian medicine (TMM).

Methods: Based on the correspondence between man and the universe (including psychosomatic integration) in fracture healing with osteopathy in TMM, we used modern physio-psychological and biomechanical principles and methods to probe the integrated, dynamic and functional characteristics of fracture healing.

Results: Based on the integration of limbs and the body, unification of the body and function and harmony of man and nature (including psychosomatic integration), fracture healing with osteopathy in TMM comprises the concept of natural functional healing of fractures, and follows the norm of considering physiological healing and psychological function as well as limb healing and motor function.

The diagnosis of spinal dural arteriovenous fistulas.

Study Design: Retrospective consecutive case series.

Objective: To review and analyze clinical presentations and radiological imaging of 326 consecutive patients with spinal dural arteriovenous fistula (SDAVF) from 2 institutions.

Summary Of Background Data: The clinical presentations of SDAVF are nonspecific.

Biological macro-idea and criterion of osteopathic fracture immobilization in China's traditional Mongolian medicine.

Objective: To investigate the biological macro-idea and criterion of osteopathic fracture immobilization in China's traditional Mongolian medicine.

Methods: Based on biological naturalism regarding the relationship between man and universe (including psychosomatic integration) in osteopathic fracture immobilization in China's traditional Mongolian medicine, we used modern physiopsychological and biomechanical principles and methods to investigate the biological macro-characteristics of humanization, behaviorism, and wholism in "dynamic" fixation of fractures.

Results: Osteopathic fracture immobilization in China's traditional Mongolian medicine is based on the fixation criterion of macro-idea and method as well as on geometry, mechanics, motion, and stress and psychological stability in "non-sheltered fixation" of fractures contained in the life view of nature, regarding the relationship between man and universe (including psychosomatic integration) and on harmony between the limbs and the whole body, between body and function, and between man and nature.