Publications by authors named "Xuecong Zheng"
LKAN: LLM-Based Knowledge-Aware Attention Network for Clinical Staging of Liver Cancer.
IEEE J Biomed Health Inform
October 2024
Article Synopsis
- Clinical staging of liver cancer (CSoLC) is crucial for assessing the severity of liver cancer and guiding treatment, with current methods in China relying on clinicians interpreting radiology reports.
- Challenges include imbalanced data, domain-specific vocabulary issues, and the complexity of unstructured radiology reports, which complicate accurate information extraction for staging.
- The proposed solution, a large language model-based Knowledge-aware Attention Network (LKAN), improves classification accuracy to 90.3% by integrating diverse data generation techniques, utilizing domain knowledge, and enhancing attention mechanisms to focus on relevant information.
Background: The routine establishment of a diverting stoma (DS) remains controversial in every patient undergoing Dixon operation. We aimed to establish a model for the risk assessment of rectal anastomotic leak (RAREAL) after Dixon in non-emergency patients with rectal cancer, using routinely available variables, by which surgeons could individualize their approach to DS.
Methods: 323 patients who underwent Dixon operation for rectal cancer from January 2015 to December 2018 were taken as the model group for retrospective study.
Protosappanin B (PSB) is a key active component of Lignum Sappan extract. Although the antiproliferative effects of Lignum Sappan extract have been demonstrated in various cancer cells, relatively little is known about the effects of PSB on tumor progression. The aim of this study was to explore the anti-tumor effects of PSB on human colon cancer cells by regulation of intracellular signaling pathways and Golgi phosphoprotein 3 (GOLPH3) expression in vitro and in vivo.
View Article and Find Full Text PDFPurpose: LACTB, regulated by a variety of microRNAs (miRNAs), is proven to be a tumor suppressor. However, there are few reports that LACTB in colon cancer cells is regulated by miRNA. Therefore, the aim of this study was to explore the miRNAs that regulate LACTB in colon cancer.
View Article and Find Full Text PDFPurpose: Liver cancer stem cells are associated with tumor progression, metastasis, and resistance to chemotherapy. Therefore, it is important to understand the proteins that support the tumor microenvironment. The suppression of ZEB2 results from inactivation of the Wnt/β catenin pathway.
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