Lokatt: a hybrid DNA nanopore basecaller with an explicit duration hidden Markov model and a residual LSTM network.

Background: Basecalling long DNA sequences is a crucial step in nanopore-based DNA sequencing protocols. In recent years, the CTC-RNN model has become the leading basecalling model, supplanting preceding hidden Markov models (HMMs) that relied on pre-segmenting ion current measurements. However, the CTC-RNN model operates independently of prior biological and physical insights.

RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion.

Unlabelled: Immunotherapies such as immune checkpoint blockade have achieved remarkable success in treating cancer. Unfortunately, response rates have been limited in multiple cancers including hepatocellular carcinoma (HCC). The critical function of epigenetics in tumor immune evasion and antitumor immunity supports harnessing epigenetic regulators as a potential strategy to enhance the efficacy of immunotherapy.

The Prognostic Value and the Oncogenic and Immunological Roles of Vacuolar Protein Sorting Associated Protein 26 A in Pancreatic Adenocarcinoma.

The identification of the prognostic markers and therapeutic targets might benefit the diagnosis and treatment of pancreatic adenocarcinoma (PAAD), one of the most aggressive malignancies. Vacuolar protein sorting associated protein 26 A (VPS26A) is a candidate prognosis gene for hepatocellular carcinoma, but its expression and function in PAAD remain unknown. The mRNA and protein expression of VPS26A in PAAD was explored and validated by bioinformatics and immunohistochemical analysis.

[Association between single nucleotides polymorphism of catalase gene and susceptibility to noise-induced hearing loss in occupational population].

Objective: To investigate the relationship between single nucleotides polymorphism of catalase(CAT) gene and susceptibility to noise-induced hearing loss(NIHL) in occupational noise exposed population.

Methods: A case-control study of 1∶1 was conducted to select 286 workers with binaural high frequency average hearing threshold ≥40 dB(HL), from 2006 to 2015 in a cohort study of occupational noise exposure workers in Henan Province. According to the type of work, the age difference was not more than 5 years and the length of exposure to noise was not more than 2 years.

A multiporous carbon family with superior stability, tunable electronic structures and amazing hydrogen storage capability.

The traditional view that natural allotropes are more stable than artificially synthesized structures is widely accepted. For instance, graphite and diamond are more energetically favorable than other new carbon allotropes no matter whether they are experimentally prepared or theoretically predicted. Surprisingly, we find that a family of multiporous carbon (N-diaphenes) could be thermodynamically more stable than natural diamond with the increase of its feature size parameter N.

A new metallic π-conjugated carbon sheet used for the cathode of Li-S batteries.

Lithium-sulfur (Li-S) batteries are considered as the most promising next generation high density energy storage devices. However, the commercialization of Li-S batteries is hindered by the shuttle effect of polysulfides, the low electronic conductivity of the sulfur cathode and a large volume expansion during lithiation. Herein, we predict a new two dimensional sp hybridized carbon allotrope (PHE-graphene) and prove its thermodynamic and kinetic stability.

Multiporous sp-hybridized boron nitride (d-BN): stability, mechanical properties, lattice thermal conductivity and promising application in energy storage.

All-solid-state lithium-sulfur (Li-S) batteries offer the possibility of high theoretical energy densities and long cycle lifetime. Finding new multiporous insulating materials or wide bandgap semiconductors suitable for the transportation of Li-ions is a key problem for the application of solid state lithium-sulfur (Li-S) batteries. In this study, an sp2-hybridized multiporous boron nitride (d-BN) is found to be able to be used as a solid electrolyte or filter in Li-S batteries due to the lower energy barriers of Li-ion diffusion along its [110] direction.

Chirality control of nonplanar lead phthalocyanine (PbPc) and its potential application in high-density storage: a theoretical investigation.

On single-crystal surfaces, achiral molecules may become chiral owing to confinement in two dimensions (2D). Metal phthalocyanines (MPcs) on Cu(001) and Ag(100) surfaces have exhibited a chiral electronic state. However, the chirality is not always desirable since crystal defects (grain boundaries) inevitably occur between two different chiral domains during the self-assembly of single layers.

Luminescence and energy-transfer properties of color-tunable Ca2Mg0.25Al1.5Si1.25O7:Ce(3+)/Eu(2+)/Tb(3+) phosphors for ultraviolet light-emitting diodes.

A series of Ca2Mg0.25Al1.5Si1.

Photoluminescence properties and energy transfer in Ce(3+) /Dy(3+) co-doped Sr(3) MgSi(2) O(8) phosphors for potential application in ultraviolet white light-emitting diodes.

Sr(3) MgSi(2) O(8) :Ce(3+) , Dy(3+) phosphors were prepared by a solid-state reaction technique and the photoluminescence properties were investigated. The emission spectra show not only a band due to Ce(3+) ions (403 nm) but also as a band due to Dy(3+) ions (480, 575 nm) (UV light excitation). The photoluminescence properties reveal that effective energy transfer occurs in Ce(3+) /Dy(3+) co-doped Sr(3) MgSi(2) O(8)phosphors, and the co-doping of Ce(3+) could enhance the emission intensity of Dy(3+) to a certain extent by transferring its energy to Dy(3+) .