A simple one step synthesis of magnetic-optical dual functional ZIF-8 in a sodalite phase for magnetically guided targeting bioimaging and drug delivery.

Functionalized metal-organic frameworks (MOFs) that integrate targeted tumor imaging and drug delivery are expected to significantly enhance the therapeutic efficacy of cancer. However, the complicated synthesis process has greatly limited their utilization in clinical application. Herein, a one-step simple method was used to construct novel multifunctional MOFs by co-loading doxorubicin (DOX) and FeO into the ZIF-8 with sodalite topology.

Hollow structural metal-organic frameworks exhibit high drug loading capacity, targeted delivery and magnetic resonance/optical multimodal imaging.

Metal-organic frameworks (MOFs) are attractive in designing drug delivery systems for the treatment of cancer because of their unique porous properties. However, the search for multifunctional MOFs with high drug loading and magnetic resonance/fluorescence imaging capacities is still a challenge and they have rarely been reported. In this article, using the intrinsic advantages of MOFs, hollow Fe-MOFs with biomolecular grafting were fabricated and shown to be capable of loading much more drugs and exhibiting targeted drug delivery, pH-controlled drug release and magnetic resonance/fluorescence imaging.

Postsynthetic Metalation Metal-Organic Framework as a Fluorescent Probe for the Ultrasensitive and Reversible Detection of PO Ions.

The self-assembly of a zinc salt with the novel ligand 4,4',4″-[(1,3,5-triazine-2,4,6-triyl)tris(sulfanediyl)]tribenzoic acid generated 3D microporous metal-organic frameworks (MOFs), namely, {[Zn(L)(O)(HO)]·4EtOH} . The frameworks with multiple Lewis basic sites exhibit easily sensitized properties. After encapsulation of the Tb cation in this Zn-MOF, the as-obtained fluorescent-functionalized Tb@Zn-MOFs not only maintain distinguished chemical stabilities but also exhibit strong characteristic emissions of trivalent terbium ions.

Size and surface controllable metal-organic frameworks (MOFs) for fluorescence imaging and cancer therapy.

Benefiting from their porous structures, metal-organic frameworks (MOFs) have attracted intensive attention for use in drug release. However, the controllable synthesis of MOFs with proper particle sizes is still very challenging, which largely limits its applications. Here, UIO-66-NH2 with controlled particle sizes in the range of 20-200 nm has been achieved successfully.

In situ growth of metal-organic frameworks (MOFs) on the surface of other MOFs: a new strategy for constructing magnetic resonance/optical dual mode imaging materials.

This work presents for the first time the synthesis of a novel nanoscale Fe-MOFs/Eu-MOFs heterostructure, in which spherical Fe-MOFs with a large surface area were introduced as a matrix for the well-dispersed growth of rodlike Eu-MOFs. The obtained Fe-MOFs/Eu-MOFs materials exhibit excellent magnetic resonance/optical imaging capacity and satisfactory drug delivery behavior.

Controllable Synthesis of a Smart Multifunctional Nanoscale Metal-Organic Framework for Magnetic Resonance/Optical Imaging and Targeted Drug Delivery.

As a result of their extraordinarily large surfaces and well-defined pores, the design of a multifunctional metal-organic framework (MOF) is crucial for drug delivery but has rarely been reported. In this paper, a novel drug delivery system (DDS) based on nanoscale MOF was developed for use in cancer diagnosis and therapy. This MOF-based tumor targeting DDS was fabricated by a simple postsynthetic surface modification process.

Fabrication of functional hollow microspheres constructed from MOF shells: Promising drug delivery systems with high loading capacity and targeted transport.

An advanced multifunctional, hollow metal-organic framework (MOF) drug delivery system with a high drug loading level and targeted delivery was designed and fabricated for the first time and applied to inhibit tumour cell growth. This hollow MOF targeting drug delivery system was prepared via a simple post-synthetic surface modification procedure, starting from hollow ZIF-8 successfully obtained for the first time via a mild phase transformation under solvothermal conditions. As a result, the hollow ZIF-8 exhibits a higher loading capacity for the model anticancer drug 5-fluorouracil (5-FU).

Synthesis and Characteristic of the NaYF4/Fe3O4@SiO2@Tb(DBM)3 . 2H2O/SiO2 Luminomagnetic Microspheres with Core-Shell Structure.

The structure and properties of the multifunctional nanoparticles were characterized by X-ray diffraction (XRD), Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), Photoluminescence spectra and Vibrating sample magnetometer (VSM). The experimental results show that the microsphere has the magnetic core and silica shell bonded with terbium complex. These multifunctional nanoparticles exhibit strong visible emission and up-conversion emission, which is based on the use of up-converting nanoparticles (UCNPs) of the NaYF4:Yb3+, Er3+/Tm3+ type that can be excited with 980 nm laser light to give a green and red luminescence, moreover, nanoparticles possess magnetism with a saturation magnetization of 18.

Synthesis and Characterization of α-ZrP@CHI Drug Deliver System.

This paper described the controlled synthesis and release properties of a new kind of multifunctional drug-release system which was prepared by encapsulation of zirconium bis-(monohydrogen orthophosphate) monohydrate (α-ZrP) with chitosan (CHI). As obtained the α-ZrP@CHI nanocomposites were found to possess the structural features of both α-ZrP and CHI. The release properties of the α-ZrP@CHI nanocomposites were evaluated using Gentamicin sulfate as the model drug.

Decorated TiO2 Nanoparticles with La and Ag Elements to Improve Photocatalytic Activity Under Visible Light for the Degradation of MO.

Visible-light photocatalyst of TiO2/La/Ag nanocomposites were successfully synthesized via the conventional sol-gel method and reducing agent of Ag+. The photocatalytic activities were evaluated by methyl orange (MO) degradation. They have remarkable photocatalytic activities compared to TiO2-Anatase, which is thanks to the separation of electron-hole pairs by Ag nanoparticles and lanthanum.

Inorganic nanovehicle for potential targeted drug delivery to tumor cells, tumor optical imaging.

In this work, an inorganic multifunctional nanovehicle was tailored as a carrier to deliver anticancer drug for tumor optical imaging and therapy. The nanovehicle could be used as a dually targeted drug nanovehicle by bonded magnetical (passive) and folic acid (active) targeting capabilities. In addition, it was developed using rhodamine 6G (R6G) as a fluorescence reagent, and an α-zirconium phosphate nanoplatform (Zr(HPO4)2·H2O, abbreviated as α-ZrP) as the anticancer drug nanovehicle.