[Cost-benefit analysis on the intervention of application iron-fortified soy sauce for anemia in Deqing 15-54 years women, Zhejiang].

Objective: To make a cost-benefit analysis on anemia intervention with iron-fortified soy sauce in 15-54 years old women.

Methods: The study was conducted in Deqing county, Zhejiang province in 2012-2013. A total 585 women as sampling size were estimated with statistical model and randomly selected by probability proportionate to size sampling.

Underweight rather than adiposity is an important predictor of death in rural Chinese adults: a cohort study.

Background: To assess the associations of body mass index (BMI) with all-cause and cause-specific mortalities among rural Chinese.

Methods: A prospective study of 28 895 individuals was conducted from 2006 to 2014 in rural Deqing, China. Height and weight were measured.

Enriched taxa were found among the gut microbiota of centenarians in East China.

Background: Gut microbiota is closely related to age. Studies from Europe and the U.S.

Poor sleep quality and influencing factors among rural adults in Deqing, China.

Background: Poor sleep quality is prevalent and is associated with cognitive decline, impaired health, and reduced quality of life. There is a lack of studies about sleep quality and its potential risk factors among rural adults aged 45 years or above under rapid urbanization in China.

Methods: In a cross-sectional survey conducted in Deqing County, China in 2015, we included 1584 adults 45+ years of age.

[Prevalence and change of type 2 diabetes mellitus among rural adults in Deqing County, Zhejiang Province in China during 2006-2014].

Objective: To describe the prevalence of type 2 diabetes mellitus( T2 DM) in rural Deqing County, Zhejiang Province, and explore its risk factors.

Methods: Random cluster sampling was used to select 8 rural communities in Deqing County, Zhejiang Province, and a cross-sectional survey was conducted in 2006-2008, 2011-2012 and 2013-2014, respectively. Totally, 6562 eligible subjects were investigated in 2006-2008, 11 763 eligible subjects in 2011-2012, and 10 904 eligible subjects in 2013-2014.

Increased prevalence and incidence of anemia among adults in transforming rural China: two cross-sectional surveys.

Background: Anemia remains one of the serious nutrition-related diseases in China, but data on incidence of anemia were less available, especially in rural area which are experiencing rapid urbanization. Out study aimed to estimate both the prevalence and incidence of anemia in transforming rural China.

Methods: We conducted a combined study of rural adults 18-64 years of age with a repeated cross-sectional component (4456 in 2006 and 2184 in 2008) and a cohort component (1424) in rural Deqing, China.

Common variants in TGFBR2 and miR-518 genes are associated with hypertension in the Chinese population.

Background: An animal study reported that TGF-β1 maturation was linked to the homeostasis of blood pressure and elastogenesis of essential hypertension (EH). Recent advances require further research of TGF-β1 receptor in EH.

Methods: A case-control study comprised of 2,012 adult hypertension case patients and 2,210 adult control subjects was conducted, and the association with blood pressure was further tested in children.

Association study of common variations of FBN1 gene and essential hypertension in Han Chinese population.

Fibrillin-1 (FBN1) was reported to have impact on the physiological arterial stiffness and vascular remodeling with hypertension of recent years. In the previous study we reported the association of four functional single nucleotide polymorphisms (SNPs) of FBN1 gene and hypertension. Here, we further investigate the association of four tagging SNPs (tagSNPs) which covered remain genetic variation blocks of FBN1 gene with hypertension, blood pressure and efficacy of antihypertensive in a South Han Chinese population.

Hepatitis B virus surface antigen (HBsAg)-positive and HBsAg-negative hepatitis B virus infection among mother-teenager pairs 13 years after neonatal hepatitis B virus vaccination.

It is unclear whether a mother who is negative for hepatitis B virus surface antigen (HBsAg) but positive for hepatitis B virus (HBV) is at potential risk for mother-to-child transmission of HBV. This study, using a paired mother-teenager population, aimed to assess whether maternal HBsAg-negative HBV infection ((hn)HBI) is a significant source of child HBV infection (HBI). A follow-up study with blood collection has been conducted on the 93 mother-teenager pairs from the initial 135 pregnant woman-newborn pairs 13 years after neonatal HBV vaccination.

Association study of AGER gene polymorphism and hypertension in Han Chinese population.

Background: Advanced glycation end products (AGEs) are produced by non-enzymatic glycation or glycoxidation of proteins, lipids and nucleic acids. The bond of AGEs and the receptor of AGE (AGER) in a pro-oxidant environment could induce immune and inflammation reaction involved in progress of microvascular disease. Accumulated evidence warrant further study on AGE-AGER pathway and genetic susceptibility to hypertension (HT).

High prevalence of hyperglycaemia and the impact of high household income in transforming rural China.

Background: The prevalence of hyperglycaemia and its association with socioeconomic factors have been well studied in developed countries, however, little is known about them in transforming rural China.

Methods: A cross-sectional study was carried out in 4 rural communities of Deqing County located in East China in 2006-07, including 4,506 subjects aged 18 to 64 years. Fasting plasma glucose (FPG) was measured.

[Relationship between HBeAg seroconversion with genotypes and HBV specific CTL in patients with chronic hepatitis B treated with Adefovir dipivoxil].

Objective: To explore relationship between HBeAg seroconversion with HBV genotypes and HBV specific CTL in patients with chronic hepatitis B (CHB) treated with Adefovir dipivoxil.

Methods: Seventy CHB patients had positive HBV DNA (HBV DNA > or = 1 x 10(4) copy/ml), 45 cases had positive HBeAg, of whom 23 cases (51. 11%) had genotype B, 22 cases (48.

[Prevalence of overweight and its relationship with hyperglycaemia in adults of rural communities in Deqing County, China].

Objective: To understand the prevalence of overweight and its relationship with hyperglycaemia in adults in rural Deqing county, China.

Method: A cross-sectional study was carried out in four rural communities randomly sampled from Deqing county, Zhejiang province, China. A total of 5840 subjects aged 18 to 64 years participated in this study.

[Influence of adefovir dipivoxil on HBV specific CTL in patients with chronic hepatitis B].

Objective: To explore the influence of adefovir dipivoxil on HBV specific CTL in patients with chronic hepatitis B (CHB).

Methods: 10 mg adefovir dipivoxil (Zhengda Tianjing Pharmaceutical Company) was used for CHB patients with positive HBV DNA (HBV DNA > or = 1 x 10(4) copies/ml), ALT > 2 x upper limit of normal value (ULN) and positive human leucocyte antigen (HLA)-A2, orally, once a day for 3 months. Real time fluorescent quantitative PCR was used to determine HBV DNA and flowcytometer was used to determine HBV specific CTL.

[Phylogenetic analysis of sporadic hepatitis E virus in Eastern China].

Objective: To understand phylogenetic characteristics of sporadic hepatitis E virus (HEV) in eastern China.

Methods: Four hundred and thirteen sera were collected from sporadic hepatitis E cases in 14 second- or first-class hospitals in Eastern China from 2005 to 2008 and detected with a nested RT-PCR assay. Partial nucleotide sequences of the HEV isolates were determined for phylogenetic analysis with prototype sequences in the GenBank.

[Relationship between tea-drinking and anaemia of rural reproductive married women in a community-based cross-sectional study in China].

Objective: To determine the prevalence of anaemia and the relationship between tea-drinking and anaemia in reproductive married women in rural China.

Method: A cross-sectional study was carried out in four rural communities in Deqing County, Zhejiang Province, China. A total of 1425 reproductive married women at the ages of 20 to 49 years participated in this study and had a satisfactory measure of hemoglobin.

[Seasonal pattern and phylogenetic analysis with human isolates of genotype-IV hepatitis E virus in swine herds, eastern China].

Objective: To determine the seasonal prevalence of genotype-IV hepatitis E virus (HEV) in swine herds in Eastern China and explore the phylogenetic relationship between swine HEV and human HEV in the situation that zoonotic features of HEV had been confirmed.

Methods: From September 2007 to June 2008, a total of 1200 swine bile specimens were collected from three slaughter houses located in Zhejiang, Anhui and Jiangsu, the Eastern China, and detected for HEV RNA by using nested RT-PCR. The positive PCR products were sequenced.