Mitochondria-targeting nanozyme for catalytical therapy and radiotherapy with activation of cGAS-STING.

Background: Overcoming radio-resistance and enhance radio-sensitivity to obtain desired therapeutic outcome plays an important role in treating cancer.

Methods: Here we constructed a versatile enzyme-like nano-radiosensitizer MDP. MDP is composed of MnCO decorated and Ru-based nanozyme with triphenylphosphine (TPP) group coordinated on the surface.

Deep learning-based deformable image registration with bilateral pyramid to align pre-operative and follow-up magnetic resonance imaging (MRI) scans.

Background: The evaluation of brain tumor recurrence after surgery is based on the comparison between tumor regions on pre-operative and follow-up magnetic resonance imaging (MRI) scans in clinical practice. Accurate alignment of MRI scans is important in this evaluation process. However, existing methods often fail to yield accurate alignment due to substantial appearance and shape changes of tumor regions.

Ab initio determination on diffusion coefficient and viscosity of FeNi fluid under Earth's core condition.

The Earth's outer core is mainly composed of Fe and Ni. The geodynamo of the Earth's core are closely correlated with the transport properties of the fluid in the Earth's core. We selected the typical FeNi fluid, and systemically calculated its diffusion coefficient and viscosity under Earth's core condition by quantum molecular dynamics simulation.

Relationship between mismatch repair protein, , , gene expression and clinicopathological characteristics in elderly colorectal cancer patients.

Background: Colorectal cancer (CRC) is common in elderly patients. Mismatch repair (MMR) protein deletion is one of the causes of CRC. The (), , and genes are important gene targets in CRC treatment and are closely related to the prognosis and survival of patients.