Spatio-temporal pattern evolution analysis of ecological networks based on the morphological spatial pattern analysis: A case study of Ningbo City, China].

The exponential expansion of urban areas has precipitated a concomitant deterioration in the natural environment. Constructing ecological networks is vital in improving landscape connectivity, protecting biodiversity, and maintaining regional sustainable development. Ningbo, China was set as the research area.

Low versus high peripheral oxygen saturation directed oxygen therapy in critically ill patients: a multicenter randomized controlled trial.

Whether low peripheral oxygen saturation (SpO) directed oxygen therapy is associated with lower mortality in critically ill patients needs further exploration. Adult critically ill patients from 11 intensive care units in China were screened. Participants were randomly assigned to the low SpO (90%-95%) group or the high SpO (≥96%) -group.

Enhancement of the urea oxidation reaction by constructing hierarchical CoFe-PBA@S/NiFe-LDH nanoboxes with strengthened built-in electric fields.

The slow kinetics of the oxygen evolution reaction (OER) present a major obstacle for efficient hydrogen production via water electrolysis. In contrast, the urea oxidation reaction (UOR), with its lower thermodynamic barrier, presents a promising alternative to OER. In this study, we designed and synthesized hierarchical CoFe- PBA@S/NiFe-LDH nanoboxes.

Achieving Dendrite-Free Lithium Metal Batteries by Constructing a Dense Lithiophilic CuSe/CuO Heterojunction Tip.

Lithium (Li) metal batteries (LMBs) have garnered widespread attention due to their high specific capacity. However, the growth of lithium dendrite severely limits their practical applications. Herein, a novel strategy is proposed to regulate the overall potential strength and lithium ions (Li) concentration on the surface of the current collector by utilizing densely distributed tip effects.

Physiologic Comparison of Airway Pressure Release Ventilation and Low Tidal Volume Ventilation in ARDS: A Randomized Controlled Trial.

Background: The physiologic effects of different ventilation strategies on patients with ARDS need to be better understood.

Research Question: In patients with ARDS receiving controlled mandatory ventilation, does airway pressure release ventilation (APRV) improve lung ventilation/perfusion (V˙/Q˙) matching and ventilation homogeneity compared with low tidal volume (LTV) ventilation?

Study Design And Methods: This study was a single-center randomized controlled trial. Patients with moderate to severe ARDS were ventilated randomly with APRV or LTV ventilation.

Effects of different VV ECMO blood flow rates on lung perfusion assessment by hypertonic saline bolus-based electrical impedance tomography.

Objective: Our study aimed to investigate the effects of different extracorporeal membrane oxygenation (ECMO) blood flow rates on lung perfusion assessment using the saline bolus-based electrical impedance tomography (EIT) technique in patients on veno-venous (VV) ECMO.

Methods: In this single-centered prospective physiological study, patients on VV ECMO who met the ECMO weaning criteria were assessed for lung perfusion using saline bolus-based EIT at various ECMO blood flow rates (gradually decreased from 4.5 L/min to 3.

Construction and enhancement of built-in electric field for efficient oxygen evolution reaction.

The construction and regulation of built-in electric field (BIEF) are considered effective strategies for enhancing the oxygen evolution reaction (OER) performance of transition metal-based electrocatalysts. Herein, we present a strategy to regulate the electronic structure of nickel-iron layered double hydroxide (NiFe-LDH) by constructing and enhancing the BIEF induced by in-situ heterojunction transformation. This concept is demonstrated through the design and synthesis of AgS@S/NiFe-LDH (p-n heterojunction) and Ag@S/NiFe-LDH (Mott-Schottky heterojunction).

Trinitarian Design of Gradient Artificial Interphase Enables Colossal Granular Li Deposits for Stable Li-Metal Batteries.

The cycling lifespan of Li-metal batteries is compromised by the unstable solid electrolyte interphase (SEI) and the continuous Li dendrites, restricting their practical implementations. Given these challenges, establishing an artificial SEI holds promise. Herein, a trinitarian gradient interphase is innovatively designed through composite coatings of magnesium fluoride (MgF), N-hexadecyltrimethylammonium chloride (CTAC), and polyvinylidene fluoride-hexafluoropropylene copolymer (PVDF-HFP) on Li-metal anode (LMA).

Achieving a smooth "adsorption-diffusion-conversion" of polysulfides enabled by MnO-ZnS p-n heterojunction for Li-S battery.

The commercial application of lithium-sulfur batteries is primarily impeded by the constant shuttling of soluble polysulfides and sluggish redox kinetics. Nowadays, the discovery of the heterojunction, which combines materials with diverse properties, offers a new perspective for overcoming these obstacles. Herein, a functional coating separator for the lithium-sulfur battery is designed using a MnO-ZnS p-n heterojunction with a spontaneous built-in electric field (BIEF).

Fospropofol disodium versus propofol for long-term sedation during invasive mechanical ventilation: A pilot randomized clinical trial.

Study Objective: Fospropofol disodium is a propofol prodrug that is water-soluble and has a reduced risk of bacterial contamination and hypertriglyceridemia compared with propofol. Prior to implementing a large randomized trial, we investigated the feasibility, initial efficacy, and safety of fospropofol disodium compared with propofol in long-term mild-to-moderate sedation in intensive care units (ICUs).

Design: Single-centered, prospective, unblind, randomized, parallel-group clinical trial.

Reinforcement of Electrocatalytic Oxygen Evolution Activity Enabled by Constructing Silver-Incorporated NiCo-PBA@NiFe-LDH Hierarchical Nanoboxes.

Complicated oxygen evolution reaction (OER) poses the bottleneck in improving the efficiency of hydrogen production through water electrolysis. Herein, an integrated strategy to modulate the electronic structure of NiFe layered double hydroxide (NiFe-LDH) is reported by constructing Ag-incorporated NiCo-PBA@NiFe-LDH heterojunction with a hierarchical hollow structure. This "double heterojunction" facilitates local charge polarization at the interface, thereby promoting electron transfer and reducing the adsorption energy of intermediates, ultimately enhancing the intrinsic activity of the catalyst.

Integrated PtCo-Hierarchical Carbon Matrix Electrocatalyst for Efficient Hydrogen Evolution Reaction.

Pt-based catalysts are regarded as state-of-the-art electrocatalysts for producing clean hydrogen energy; however, their wide application is restricted by their low abundance, high cost, and poor stability. Herein, we report an integrated PtCo-hierarchical carbon matrix electrocatalyst (Pt/Co@NCNTs, PtCo@NCNTs, PtCo@NCNTs, and PtCo@NCNTs) that is developed using a thermally driven Co migration strategy forming alloy nanoparticles to achieve efficient hydrogen evolution reaction (HER). Benefiting from its electronic regulation effect and unique hierarchical hollow structure, the PtCo@NCNTs catalyst loaded with 11.

Remimazolam besylate versus propofol for deep sedation in critically ill patients: a randomized pilot study.

Objective: To compare the efficacy and safety of remimazolam besylate and propofol for deep sedation in critically ill patients.

Methods: In this single-center, prospective, randomized, controlled pilot study, patients in the intensive care unit (ICU) requiring deep sedation were randomized to receive remimazolam besylate or propofol intravenously. Deep sedation was defined as a Richmond Agitation and Sedation Scale (RASS) score of - 4 or - 5.

Reinforcing the Adsorption and Conversion of Polysulfides in Li-S Battery by Incorporating Molybdenum into MnS/MnO Nanorods.

The Sabatier principle suggests that an excessive adsorption of lithium polysulfides (LiPSs) by metal compounds may hinder their conversion in the absence of a conversion module. Therefore, it is imperative to establish a synergetic effect mechanism between "strong adsorption" and "rapid conversion" for LiPSs. To achieve this coexistence, a molybdenum-doped MnS/MnO@C porous structure is designed as a multifunctional coating on the polypropylene (PP) separator.

Field-Assisted Regulation Induced by Cobalt-Doped ZnO for Dendrite-Free Lithium Metal Anodes.

Lithium metal batteries are deemed as an optimal candidate for the next generation of durable energy storage devices. However, the growth of lithium dendrite and significant volume expansion pose as obstacles that impede the application of lithium metal batteries. In this work, a functional copper current collector was designed by coating it with Co-doped ZnO (Co/ZnO) to enhance the lithiophilicity through local electric fields and built-in magnetic fields induced by the ferromagnetic material.

A Highly-Lithiophilic MnO/ZnO-Modified Carbon Nanotube Film for Dendrite-Free Lithium Metal Anodes.

Lithium metal anode is deemed as a potential candidate for high energy density batteries, which has attracted increasing attention. Unfortunately, Li metal anode suffers from issues such as dendrite grown and volume expansion during cycling, which hinders its commercialization. Herein, we designed a porous and flexible self-supporting film comprising of single-walled carbon nanotube (SWCNT) modified with a highly-lithiophilic heterostructure (MnO/ZnO@SWCNT) as the host material for Li metal anodes.

Deletion of the tyrosine phosphatase Shp2 in cervical cancer cells promotes reprogramming of glutamine metabolism.

Shp2 is a nonreceptor protein tyrosine phosphatase that is overexpressed in cervical cancer. However, the role of Shp2 in the regulation of cervical cancer metabolism and tumorigenesis is unclear. EGFR signaling pathways are commonly dysregulated in cervical cancer.

Carotane sesquiterpenoids A-G from the desert endophytic fungus sp. HM 166.

Seven undescribed carotane sesquiterpenoids named fusanoids A-G (1-7), along with one known analog (8) and two known sesterterpenes (9 and 10), were isolated from the fermentation broth of the desert endophytic fungi sp. HM166. The structures of the compounds, including their absolute configurations, were determined by spectroscopic data, single-crystal X-ray diffraction analysis, and ECD calculations.

Lithiophilic hollow Co[Co(CN)] embedded carbon nanotube film for dendrite-free lithium metal anodes.

Lithium metal is considered to be an ideal anode material due to its ultra-high theoretical capacity and extremely low electric potential. Unfortunately, the infinite volume expansion and unregulated formation of lithium dendrites in the plating/stripping process restrict its practical utilization. Herein, we designed a hollow Co[Co(CN)] (CoCoPBA) embedded high-conductivity carbon film as a three-dimensional (3D) lithiophilic current collector (h-CoCoPBAs@SWCNT).

Boosting oxygen evolution reaction activity and durability of phosphate doped Ni(OH)/FeOOH hierarchical microtubes by morphology engineering and reconstruction strategy.

Developing electrocatalysts with remarkable activity and durability is significant for efficient oxygen evolution reaction (OER). Herein, we designed phosphate doped Ni(OH)/FeOOH hierarchical microtubes (denoted as PO-Ni(OH)/FeOOH HMTs), obtained by phosphate doped NiFe Prussian blue analogue hierarchical microtubes (denoted as P-NF-PBA HMTs) completely reconstructing in OER process. PO-Ni(OH)/FeOOH HMTs possess an extremely low overpotential of 237 mV at 30 mA cm in alkaline electrolyte with the Tafel slope of 35 mV dec, and the catalysts can maintain excellent durability for 100 h at 30 mA cm.

Role of Cholinergic Anti-Inflammatory Pathway in Protecting Sepsis-Induced Acute Lung Injury through Regulation of the Conventional Dendritic Cells.

Background: The cholinergic anti-inflammatory pathway connects the immune response system and the nervous system via the vagus nerve. The key regulatory receptor is the 7-subtype of the nicotinic acetylcholine receptor (7nAChR). Cholinergic anti-inflammatory pathway has been proved to be effective in suppressing the inflammation responses in acute lung injury (ALI).